MEOX2 regulates nuclear factor-B activity in vascular endothelial cells through interactions with p65 and IB

Cardiovascular Research

Volumn 87, Issue 4, 2010, Pages 723-731

  Chen, Yun ^a,d   Rabson, Arnold B ^b   Gorski, David H ^c  

^a ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b CHILD HEALTH INSTITUTE OF NEW JERSEY   (United States)

^c WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d WASHINGTON UNIVERSITY   (United States)

Author keywords

Angiogenesis; Homeodomain protein; Nuclear factor B; Transcriptional regulation; Vascular endothelial cell

Indexed keywords

HOMEODOMAIN PROTEIN; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN MEOX 2; PROTEIN P50; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANGIOGENESIS; ARTICLE; ATHEROSCLEROSIS; CELL NUCLEUS; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; VASCULAR ENDOTHELIUM;

ANIMALS; BINDING SITES; CELL NUCLEUS; CELLS, CULTURED; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; GENES, REPORTER; HOMEODOMAIN PROTEINS; HUMANS; I-KAPPA B KINASE; IMMUNOPRECIPITATION; INHIBITOR OF DIFFERENTIATION PROTEIN 1; INHIBITOR OF DIFFERENTIATION PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; MICROSCOPY, FLUORESCENCE; MUSCLE PROTEINS; NEOPLASM PROTEINS; PROMOTER REGIONS, GENETIC; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, TERTIARY; RATS; TRANSCRIPTION FACTOR RELA; TRANSFECTION;

EID: 77955871524     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvq117     Document Type: Article

References (28)

1. Bell SE, Mavila A, Salazar R, Bayless KJ, Kanagala S, Maxwell SA et al. Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling. J Cell Sci 2001;114: 2755-2773.
2. Gorski DH, LePage DF, Patel CV, Copeland NG, Jenkins NA, Walsh K. Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells. Mol Cell Biol 1993;13:3722-3733.
3. Gorski DH, Leal AJ. Inhibition of endothelial cell activation by the homeobox gene Gax. J Surg Res 2003;111:91-99.
4. Grigoriou M, Kastrinaki MC, Modi WS, Theodorakis K, Mankoo B, Pachnis V et al. Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3. Genomics 1995;26:550-555.
5. Patel S, Leal AD, Gorski DH. The homeobox gene Gax inhibits angiogenesis through inhibition of nuclear factor-{kappa}B-dependent endothelial cell gene expression. Cancer Res 2005;65:1414-1424.
6. Chen Y, Leal AD, Patel S, Gorski DH. The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences. J Biol Chem 2007;282:507-517.
7. Smith RC, Branellec D, Gorski DH, Guo K, Perlman H, Dedieu JF et al. p21CIP1-mediated inhibition of cell proliferation by overexpression of the gax homeodomain gene. Genes Dev 1997;11:1674-1689.
8. Hoffmann A, Baltimore D. Circuitry of nuclear factor kappaB signaling. Immunol Rev 2006;210:171-186.
9. Klein S, de Fougerolles AR, Blaikie P, Khan L, Pepe A, Green CD et al. Alpha 5 beta 1 integrin activates an NF-kappa B-dependent program of gene expression important for angiogenesis and inflammation. Mol Cell Biol 2002;22:5912-5922.
10. Oitzinger W, Hofer-Warbinek R, Schmid JA, Koshelnick Y, Binder BR, de Martin R. Adenovirus-mediated expression of a mutant IkappaB kinase 2 inhibits the response of endothelial cells to inflammatory stimuli. Blood 2001;97:1611-1617.
11. Ko HM, Seo KH, Han SJ, Ahn KY, Choi IH, Koh GY et al. Nuclear factor kappaB dependency of platelet-activating factor-induced angiogenesis. Cancer Res 2002;62: 1809-1814.
12. Kim KE, Gu C, Thakur S, Vieira E, Lin JC, Rabson AB. Transcriptional regulatory effects of lymphoma-associated NFKB2/lyt10 protooncogenes. Oncogene 2000;19: 1334-1345.
13. Hallahan DE, Virudachalam S, Kuchibhotla J. Nuclear factor kappaB dominant negative genetic constructs inhibit X-ray induction of cell adhesion molecules in the vascular endothelium. Cancer Res 1998;58:5484-5488.
14. Littlewood TD, Hancock DC, Danielian PS, Parker MG, Evan GI. A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of het-erologous proteins. Nucleic Acids Res 1995;23:1686-1690.
15. Nelson DE, Ihekwaba AE, Elliott M, Johnson JR, Gibney CA, Foreman BE et al. Oscillations in NF-kappaB signaling control the dynamics of gene expression. Science 2004; 306:704-708.
16. Chen Y, Gorski DH. Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5. Blood 2008;111: 1217-1226.
17. Goydos JS, Mann B, Kim HJ, Gabriel EM, Alsina J, Germino FJ et al. Detection of B-RAF and N-RAS mutations in human melanoma. J Am Coll Surg 2005;200:362-370.
18. Nishiyama K, Takaji K, Kataoka K, Kurihara Y, Yoshimura M, Kato A et al. Id1 gene transfer confers angiogenic property on fully differentiated endothelial cells and contributes to therapeutic angiogenesis. Circulation 2005;112:2840-2850.
19. Shono T, Ono M, Izumi H, Jimi SI, Matsushima K, Okamoto T et al. Involvement of the transcription factor NF-kappaB in tubular morphogenesis of human microvascular endothelial cells by oxidative stress. Mol Cell Biol 1996;16:4231-4239.
20. Yoshida A, Yoshida S, Ishibashi T, Kuwano M, Inomata H. Suppression of retinal neo-vascularization by the NF-kappaB inhibitor pyrrolidine dithiocarbamate in mice. Invest Ophthalmol Vis Sci 1999;40:1624-1629.
21. Tabruyn SP, Griffioen AW. A new role for NF-kappaB in angiogenesis inhibition. Cell Death Differ 2007;14:1393-1397.
22. Tabruyn SP, Griffioen AW. NF-kappa B: a new player in angiostatic therapy. Angiogen-esis 2008;11:101-106.
23. Ghosh S, Karin M. Missing pieces in the NF-kappaB puzzle. Cell 2002;109(Suppl.): S81-S96.
24. dela Paz NG, Simeonidis S, Leo C, Rose DW, Collins T. Regulation of NF-kappaB-dependent gene expression by the POU domain transcription factor Oct-1. J Biol Chem 2007;282:8424-8434.
25. Chariot A, Gielen J, Merville MP, Bours V. The homeodomain-containing proteins: an update on their interacting partners. Biochem Pharmacol 1999;58:1851-1857.
26. Chariot A, Princen F, Gielen J, Merville MP, Franzoso G, Brown K et al. IkappaB-alpha enhances transactivation by the HOXB7 homeodomain-containing protein. J Biol Chem 1999;274:5318-5325.
27. Viatour P, Legrand-Poels S, van Lint C, Warnier M, Merville MP, Gielen J et al. Cyto-plasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3. J Biol Chem 2003;278:46541-46548.
28. Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R et al. Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease. Nat Med 2005; 11:959-965.