Evaluation of cxcr4 inhibition in the prevention and intervention model of laser-induced choroidal neovascularization

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 7, 2010, Pages 3666-3672

  Lee, Edwin ^a   Rewolinski, David ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [(5 FLUORO 1,2 DIHYDRO 2 OXO 3H INDOL 3 YLIDENE)METHYL] N (2 HYDROXY 3 MORPHOLINOPROPYL) 2,4 DIMETHYL 1H PYRROLE 3 CARBOXAMIDE; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; FLT3 LIGAND; ISOLECTIN B4; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLERIXAFOR; PROTEIN TYROSINE KINASE INHIBITOR; STEM CELL FACTOR; STROMAL CELL DERIVED FACTOR 1; VASCULOTROPIN RECEPTOR; 5 ((5 FLUORO 2 OXO 1,2 DIHYDRO 3H INDOL 3 YLIDENE)METHYL) N (2 HYDROXY 3 MORPHOLIN 4 YLPROPYL) 2,4 DIMETHYL 1H PYRROLE 3 CARBOXAMIDE; 5-((5-FLUORO-2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL)-N-(2-HYDROXY-3-MORPHOLIN-4-YLPROPYL)-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE; ACTIN; CXCR4 PROTEIN, RAT; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; MORPHOLINE DERIVATIVE; PROTEIN TYROSINE KINASE;

ACTIN POLYMERIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRUCH MEMBRANE; CONTROLLED STUDY; DIODE LASER; DRUG EFFICACY; DRUG TARGETING; ENDOTHELIUM CELL; ENDOTHELIUM PRECURSOR CELL; FEMALE; HEMATOPOIETIC STEM CELL; LEUKOCYTE COUNT; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; OSMOTIC PUMP; PRIORITY JOURNAL; RAT; RETINA MACULA AGE RELATED DEGENERATION; SIGNAL TRANSDUCTION; STAINING; STEM CELL; SUBRETINAL NEOVASCULARIZATION; ANIMAL; BROWN NORWAY RAT; CAPILLARY PERMEABILITY; DISEASE MODEL; DRUG ANTAGONISM; EXUDATIVE MACULAR DEGENERATION; FLOW CYTOMETRY; FLUORESCENCE ANGIOGRAPHY; LASER COAGULATION; LEUKOCYTOSIS; METABOLISM; PATHOLOGY;

ACTINS; ANIMALS; BRUCH MEMBRANE; CAPILLARY PERMEABILITY; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; FLUORESCEIN ANGIOGRAPHY; HETEROCYCLIC COMPOUNDS; INDOLES; LASER COAGULATION; LEUKOCYTE COUNT; LEUKOCYTOSIS; MORPHOLINES; RATS; RATS, INBRED BN; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CXCR4; WET MACULAR DEGENERATION;

EID: 77955868244     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3802     Document Type: Article

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