Global differences in causes, management, and survival after severe trauma: The recombinant activated factor VII phase 3 trauma trial

Journal of Trauma - Injury, Infection and Critical Care

Volumn 69, Issue 2, 2010, Pages 344-352

  Christensen, Michael C ^a   Parr, Michael ^b   Tortella, Bartholomew J ^c   Malmgren, Johan ^d   Morris, Stephen ^e   Rice, Todd ^f   Holcomb, John B ^g  

^a NOVO NORDISK A S   (Denmark)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c NOVO NORDISK INC   (United States)

^d SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^g UNIVERSITY OF TEXAS   (United States)

Author keywords

Case management; International comparison; Mortality; Predictors; Trauma

Indexed keywords

FRESH FROZEN PLASMA; LACTIC ACID; RECOMBINANT BLOOD CLOTTING FACTOR 7A;

ARTICLE; BLEEDING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ERYTHROCYTE TRANSFUSION; GEOGRAPHY; HUMAN; INJURY; INJURY SEVERITY; MAJOR CLINICAL STUDY; MORTALITY; MULTICENTER STUDY; PRACTICE GUIDELINE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE; TREATMENT OUTCOME; VENTILATOR;

EID: 77955867900     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e3181e74c69     Document Type: Article

References (25)

1. Shafi S, Stewart RM, Nathens AB, Friese RS, Frankel H, Gentilello LM. Significant variations in mortality occur at similarly designated trauma centers. Arch Surg. 2009;144:64-68.
2. Squyer E IV, Cherry RA, Lehman E, et al. Comparison of trauma mortality between two hospitals in Turkey to one trauma center in the US. Eur J Emerg Med. 2008;15:209-213.
3. Cheng CH, Graham CA, Gabbe BJ, et al. Trauma care systems: a comparison of trauma care in Victoria, Australia, and Hong Kong, China. Ann Surg. 2008;247:335-342.
4. Roudsari BS, Nathens AB, Cameron P, et al. International comparison of prehospital trauma care systems. Injury. 2007;38:993-1000.
5. Edwards A, Di Bartolomeo S, Chieregato A, et al. A comparison of European Trauma Registries. The first report from the EuroTARN Group. Resuscitation. 2007;75:286-297.
6. Holcomb JB, Wade CE, Michalek JE, et al. Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients. Ann Surg. 2008;248:447-458.
7. Mock CN, Jurkovich GJ, nii-Amon-Kotei D, Arreola-Risa C, Maier RV. Trauma mortality patterns in three nations at different economic levels: implications for global trauma system development. J Trauma. 1998;44:804-812.
8. MacKenzie EJ, Rivara FP, Jurkovich GJ, et al. A national evaluation of the effect of trauma-center care on mortality. N Engl J Med. 2006;354:366-378.
9. Hoyt DB, Dutton RP, Hauser CJ, et al. Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice. J Trauma. 2008;65:755-764.
10. Roudsari BS, Nathens AB, Arreola-Risa C, et al. Emergency Medical Service (EMS) systems in developed and developing countries. Injury. 2007;38:1001-1013.
11. DeKeyser F, Avitzour M, Watts DD, Trask AL, Muggia-Sullam M. International trauma care: a comparison between Jerusalem, Israel, and Fairfax County, Virginia, USA. Isr Med Assoc J. 2002;4:103-108.
12. Dutton R, Hauser C, Boffard K, et al. Scientific and logistical challenges in designing the CONTROL trial: recombinant factor VIIa in severe trauma patients with refractory bleeding. Clin Trials. 2009;6:467-479.
13. Rotondo MF, Zonies DH. The damage control sequence and underlying logic. Surg Clin North Am. 1997;77:761-777.
14. McIntyre L, Hebert PC, Wells G, et al; Canadian Critical Care Trials Group. Is a restrictive transfusion strategy safe for resuscitated and critically ill trauma patients? J Trauma. 2004;57:563-568.
15. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med. 2000;342:1301-1308.
16. Perdue PW, Watts DD, Kaufmann CR, Trask AL. Differences in mortality between elderly and younger adult trauma patients: geriatric status increases risk of delayed death. J Trauma. 1998;45:805-810.
17. George RL, McGwin G Jr, Metzger J, Chaudry IH, Rue LW III. The association between gender and mortality among trauma patients as modified by age. J Trauma. 2003;54:464-471.
18. Huber-Wagner S, Qvick M, Mussack T, et al; Working Group on Polytrauma of German Trauma Society (DGU). Massive blood transfusion and outcome in 1062 polytrauma patients: a prospective study based on the Trauma Registry of the German Trauma Society. Vox Sang. 2007;92:69-78.
19. Hindy-François C, Meyer P, Blanot S, et al. Admission base deficit as a long-term prognostic factor in severe pediatric trauma patients. J Trauma. 2009;67:1272-1277.
20. Mikulaschek A, Henry SM, Donovan R, Scalea TM. Serum lactate is not predicted by anion gap or base excess after trauma resuscitation. J Trauma. 1996;40:218-222. (Pubitemid 126424993)
21. Malone DL, Dunne J, Tracy JK, Putnam AT, Scalea TM, Napolitano LM. Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma. 2003;54:898-905.
22. Robinson WP III, Ahn J, Stiffler A, et al. Blood transfusion is an independent predictor of increased mortality in nonoperatively managed blunt hepatic and splenic injuries. J Trauma. 2005;58:437-444.
23. Moore FA, Moore EE, Sauaia A. Blood transfusion: an independent risk factor for postinjury multiple organ failure. Arch Surg. 1997;132: 620-625.
24. Tien H, Nascimento B Jr, Callum J, Rizoli S. An approach to transfusion and hemorrhage in trauma: current perspectives on restrictive transfusion strategies. Can J Surg. 2007;50:202-209.
25. Haider AH, Chang DC, Efron DT, Haut ER, Crandall M, Cornwell EE III. Race and insurance status as risk factors for trauma mortality. Arch Surg. 2008;143:945-949.