Massive blood transfusion and outcome in 1062 polytrauma patients: A prospective study based on the Trauma Registry of the German Trauma Society

Vox Sanguinis

Volumn 92, Issue 1, 2007, Pages 69-78

  Huber Wagner, S ^a,b   Qvick, M ^a,b   Mussack, T ^a   Euler, E ^a   Kay, M V ^a   Mutschler, W ^a,b   Kanz, K G ^a,b   Barth, F ^b   Bonk, A D ^b   Bouillon, B ^b   Grimme, K ^b   Grote, S ^b   Grotz, M ^b   Hering, M ^b   Kleiner, H M ^b   Krettek, C ^b   Kuhne C ^b   Kumpf, L ^b   Lackner, C ^b   Ledendecker, K ^b   Lefering, R ^b   Lindhorst, E ^b   Marzi, I ^b   Meyer, H ^b   Muller S ^b   Nast Kolb, D ^b   Neugebauer, E ^b   Oestern, H J ^b   Paffrath, T ^b   Pape, H C ^b   Probst, C ^b   Raum, M ^b   Rixen, D ^b   Ruchholtz, S ^b   Sauerland, S ^b   Schweigkofler, U ^b   Seekamp, A ^b   Simon, R ^b   Steitz, O ^b   Strohecker, B ^b   Tjardes, T ^b   Walcher, F ^b   Waydhas, C ^b   Westhoff, J ^b   Wittke, M ^b   more..

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b Chirurgische Klinik und Poliklinik Innenstadt ^*

Author keywords

Massive blood transfusion; Organ failure; Outcome; Polytrauma; Resuscitation; Sepsis

Indexed keywords

ADULT; AGED; ARTICLE; BLOOD TRANSFUSION; COMPARATIVE STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; ERYTHROCYTE CONCENTRATE; FEMALE; GERMANY; GLASGOW COMA SCALE; GROUPS BY AGE; HIGH RISK POPULATION; HUMAN; INCIDENCE; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MASSIVE BLOOD TRANSFUSION; MEDICAL SOCIETY; MORTALITY; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; OUTCOME ASSESSMENT; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; REGISTER; SCORING SYSTEM; SEPSIS; SURVIVAL RATE; THROMBOPLASTIN TIME;

ADULT; BLOOD TRANSFUSION; EMERGENCY MEDICAL SERVICES; EMERGENCY SERVICE, HOSPITAL; FEMALE; GERMANY; HEMORRHAGE; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; ODDS RATIO; PROGNOSIS; PROSPECTIVE STUDIES; REGISTRIES; REGRESSION ANALYSIS; RISK FACTORS; SEPSIS; SURVIVAL ANALYSIS;

EID: 33845681164     PISSN: 00429007     EISSN: 14230410     Source Type: Journal    
DOI: 10.1111/j.1423-0410.2006.00858.x     Document Type: Article

References (83)

1. Vaslef SN, Knudsen NW, Neligan PJ, Sebastian MW: Massive transfusion exceeding 50 units of blood products in trauma patients. J Trauma 2002; 53:291-296
2. Como JJ, Dutton RP, Scalea TM, Edelman BB, Hess JR: Blood transfusion rates in the care of acute trauma. Transfusion 2004; 44:809-813
3. Working Group on Polytrauma of the German Society of Trauma Surgery (DGU): Annual Report of the German Trauma Registry. Cologne 2003, www.traumaregister.de
4. Labovich TM: Transfusion therapy: nursing implications. Clin J Oncol Nurs 1997; 1:61-72
5. Hakala P, Hiippala S, Syrjala M, Randell T: Massive blood transfusion exceeding 50 units of plasma poor red cells or whole blood: the survival rate and the occurrence of leukopenia and acidosis. Injury 1999; 30:619-622
6. Phillips GR 3rd, Kauder DR, Schwab CW: Massive blood loss in trauma patients. The benefits and dangers of transfusion therapy. Postgrad Med 1994; 95:7-72
7. Drummond JC, Petrovitch CT: The massively bleeding patient. Anesthesiol Clin North Am 2001; 19:633-649
8. Cosgriff N, Moore EE, Sauaia A, Kenny-Moynihan M, Burch JM, Galloway B: Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited. J Trauma 1997; 42:857-861; discussion 61-62
9. DeLoughery TG: Coagulation defects in trauma patients: etiology, recognition, and therapy. Crit Care Clin 2004; 20:13-24
10. Crosson JT: Massive transfusion. Clin Laboratory Med 1996; 16:873-882
11. Goskowicz R: The complications of massive transfusion. Anesthesiol Clin North Am 1999; 17:959-978
12. Dzik S, Blajchman MA, Blumberg N, Kirkley SA, Heal JM, Wood K: Current research on the immunomodulatory effect of allogeneic blood transfusion. Vox Sang 1996; 70:187-194
13. Innerhofer P, Luz G, Spotl L, Hobisch-Hagen P, Schobersberger W, Fischer M, Nussbaumer W, Lochs A, Irschick E: Immunologic changes after transfusion of autologous or allogeneic buffy coat-poor versus white cell-reduced blood to patients undergoing arthroplasty. I. Proliferative T-cell responses and the balance of helper and suppressor T cells. Transfusion 1999; 39:1089-1096
14. Innerhofer P, Tilz G, Fuchs D, Luz G, Hobisch-Hagen P, Schobersberger W, Nussbaumer W, Lochs A, Irschick E: Immunologic changes after transfusion of autologous or allogeneic buffy coat-poor versus WBC-reduced blood transfusions in patients undergoing arthroplasty. II. Activation of T cells, macrophages, and cell-mediated lympholysis. Transfusion 2000; 40:821-827
15. Bengtsson A, Avall A, Hyllner M, Bengtson JP: Formation of complement split products and proinflammatory cytokines by reinfusion of shed autologous blood. Toxicol Lett 1998; 100-101:129-133
16. Fransen E, Maessen J, Dentener M, Senden N, Buurman W: Impact of blood transfusions on inflammatory mediator release in patients undergoing cardiac surgery. Chest 1999; 116:1233-1239
17. Avall A, Hyllner M, Bengtson JP, Carlsson L, Bengtsson A: Postoperative inflammatory response after autologous and allogeneic blood transfusion. Anesthesiology 1997; 87:511-516
18. Schmidt H, Bendtzen K, Mortensen PE: The inflammatory cytokine response after autotransfusion of shed mediastinal blood. Acta Anaesthesiol Scand 1998; 42:558-564
19. Haynes SL, Wong JC, Torella F, Dalrymple K, Pilsworth L, McCollum CN: The influence of homologous blood transfusion on immunity and clinical outcome in aortic surgery. Eur J Vasc Endovasc Surg 2001; 22:244-250
20. Harvey MP, Greenfield TP, Sugrue ME, Rosenfeld D: Massive blood transfusion in a tertiary referral hospital. Clinical outcomes and haemostatic complications. Med J Aust 1995; 163:356-359
21. Lapointe LA, Von Rueden KT: Coagulopathies in trauma patients. AACN Clin Issues 2002; 13:192-203
22. Hellstern P, Haubelt H: Indications for plasma in massive transfusion. Thromb Res 2002; 107:S19-S22
23. Schreiber MA, Differding J, Thorborg P, Mayberry JC, Mullins RJ: Hypercoagulability is most prevalent early after injury and in female patients. J Trauma 2005; 58:475-480; discussion 80-81
24. Spahn DR, Rossaint R: Coagulopathy and blood component transfusion in trauma. Br J Anaesth 2005; 95:130-139
25. Ho AM, Karmakar MK, Dion PW: Are we giving enough coagulation factors during major trauma resuscitation? Am J Surg 2005; 190:479-484
26. Hardy JF, De Moerloose P, Samama M: Massive transfusion and coagulopathy: pathophysiology and implications for clinical management. Can J Anaesth 2004; 51:293-310
27. Toy P, Popovsky MA, Abraham E, Ambruso DR, Holness LG, Kopko PM, McFarland JG, Nathens AB, Silliman CC, Stroncek D: Transfusion-related acute lung injury: definition and review. Crit Care Med 2005; 33:721-726
28. Silliman CC, Paterson AJ, Dickey WO, Stroneck DF, Popovsky MA, Caldwell SA, Ambruso DR: The association of biologically active lipids with the development of transfusion-related acute lung injury: a retrospective study. Transfusion 1997; 37:719-726
29. Takala A, Jousela I, Takkunen O, Kautiainen H, Jansson SE, Orpana A, Karonen SL, Repo H: A prospective study of inflammation markers in patients at risk of indirect acute lung injury. Shock 2002; 17:252-257
30. Goodnough LT: Risks of blood transfusion. Crit Care Med 2003; 31:S678-S686
31. Medeiros BC, Kogel KE, Kane MA: Transfusion-related acute lung injury (TRALI) following platelet transfusion in a patient receiving high-dose interleukin-2 for treatment of metastatic renal cell carcinoma. Transfus Apher Sci 2003; 29:25-27
32. Tsalis K, Ganidou M, Blouhos K, Vasiliadis K, Betsis D: Transfusion-related acute lung injury: a life-threatening transfusion reaction. Medical Sci Monit 2005; 11:CS19-CS22
33. Brander L, Reil A, Bux J, Taleghani BM, Regli B, Takala J: Severe transfusion-related acute lung injury. Anesth Analg 2005; 101:499-501.
34. Kao GS, Wood IG, Dorfman DM, Milford EL, Benjamin RJ: Investigations into the role of anti-HLA class II antibodies in TRALI. Transfusion 2003; 43:185-191
35. Gong MN, Thompson BT, Williams P, Pothier L, Boyce PD, Christiani DC: Clinical predictors of and mortality in acute respiratory distress syndrome: potential role of red cell transfusion. Crit Care Med 2005; 33:1191-1198
36. Lima EQ, Zanetta DM, Castro I, Massarollo PC, Mies S, Machado MM, Yu L: Risk factors for development of acute renal failure after liver transplantation. Ren Fail 2003; 25:553-560
37. Schwilk B, Wiedeck H, Stein B, Reinelt H, Treiber H, Bothner U: Epidemiology of acute renal failure and outcome of haemodiafiltration in intensive care. Intensive Care Med 1997; 23:1204-1211
38. Moore FA, Moore EE, Sauaia A: Blood transfusion. An independent risk factor for post-injury multiple organ failure. Arch Surg 1997; 132:620-624; discussion 4-5
39. Sauaia A, Moore FA, Moore EE, Haenel JB, Read RA, Lezotte DC: Early predictors of post-injury multiple organ failure. Arch Surg 1994; 129:39-45
40. Zallen G, Offner PJ, Moore EE, Blackwell J, Ciesla DJ, Gabriel J, Denny C, Silliman CC: Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg 1999; 178:570-572
41. Hensler T, Heinemann B, Sauerland S, Lefering R, Bouillon B, Andermahr J, Neugebauer EA: Immunologic alterations associated with high blood transfusion Volume after multiple injury: effects on plasmatic cytokine and cytokine receptor concentrations. Shock 2003; 20:497-502
42. Ciesla DJ, Moore EE, Johnson JL, Burch JM, Cothren CC, Sauaia A: A 12-year prospective study of post-injury multiple organ failure: has anything changed? Arch Surg 2005; 140:432-438; discussion 8-40
43. Ciesla DJ, Moore EE, Johnson JL, Sauaia A, Cothren CC, Moore JB, Burch JM: Multiple organ dysfunction during resuscitation is not post-injury multiple organ failure. Arch Surg 2004; 139:590-594; discussion 4-5
44. Sauaia A, Moore FA, Moore EE, Lezotte DC: Early risk factors for post-injury multiple organ failure. World J Surg 1996; 20:392-400
45. Malone DL, Dunne J, Tracy JK, Putnam AT, Scalea TM, Napolitano LM: Blood transfusion, independent of shock severity, is associated with worse outcome in trauma. J Trauma 2003; 54:898-905; discussion -7
46. Dunne JR, Malone DL, Tracy JK, Napolitano LM: Allogenic blood transfusion in the first 24 hours after trauma is associated with increased systemic inflammatory response syndrome (SIRS) and death. Surg Infect (Larchmt) 2004; 5:395-404
47. Shander A: Emerging risks and outcomes of blood transfusion in surgery. Semin Hematol 2004; 41:117-124
48. Brecher MA: Technical Manual. Bethesda, MD, American Association of Blood Banks, 2003.
49. Popovsky MA, Moore SB: Diagnostic and pathogenetic considerations in transfusion-related acute lung injury. Transfusion 1985; 25:573-577
50. Blajchman MA: Incidence and significance of the bacterial contamination of blood components. Dev Biol (Basel) 2002; 108:59-67
51. Dodd RY, Notari EP, Stramer SL: Current prevalence and incidence of infectious disease markers and estimated window-period risk in the American Red Cross blood donor population. Transfusion 2002; 42:975-979
52. Schreiber GB, Busch MP, Kleinman SH, Korelitz JJ: The risk of transfusion-transmitted viral infections. The Retrovirus Epidemiology Donor Study. N Engl J Med 1996; 334:1685-1690
53. Wilson RF, Dulchavsky SA, Soullier G, Beckman B: Problems with 20 or more blood transfusions in 24 hours. Am Surg 1987; 53:410-417
54. Kivioja A, Myllynen P, Rokkanen P: Survival after massive transfusions exceeding four blood volumes in patients with blunt injuries. Am Surg 1991; 57:398-401
55. Dennis JW: Blood replacement, massive transfusion and hemostasis in hemorrhagic shock. Trauma Q 1992; 8:62-68
56. Cinat ME, Wallace WC, Nastanski F, West J, Sloan S, Ocariz J, Wilson SE: Improved survival following massive transfusion in patients who have undergone trauma. Arch Surg 1999; 134:964-968; discussion 8-70
57. Velmahos GC, Chan L, Chan M, Tatevossian R, Cornwell EE, 3rd Asensio JA, Berne TV, Demetriades D: Is there a limit to massive blood transfusion after severe trauma? Arch Surg 1998; 133:947-952
58. Trauma Register of the German Society of Trauma Surgery: 'Scoring' study committee of the German Society of Trauma Surgery. Unfallchirurg 1994; 97:230-237
59. Ruchholtz S: The Trauma Registry of the German Society of Trauma Surgery as a basis for interclinical quality management. A multicenter study of the German Society of Trauma Surgery. Unfallchirurg 2000; 103:30-37
60. Ruchholtz S: External quality management in the clinical treatment of severely injured patients. Unfallchirurg 2004; 107:835-843
61. Ruchholtz S, Nast-Kolb D, Waydhas C, Lefering R: The trauma register of the 'Polytrauma' Committee of the German Society of Trauma Surgery as the basis for quality management in the management of severely injured patients. Langenbecks Arch Chir Suppl Kongressbd 1997; 114:1265-1267
62. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22:707-710
63. Bone RC: Let's agree on terminology: definitions of sepsis. Crit Care Med 1991; 19:973-976
64. American College of Surgeons: Advanced Trauma Life Support for Doctors - Student Course Manual, 7th edn, Chicago, 2004
65. Stewart RM, Myers JG, Dent DL, Ermis P, Gray GA, Villarreal R, Blow O, Woods B, McFarland M, Garavaglia J, Root HD, Pruitt BA Jr: Seven hundred fifty-three consecutive deaths in a level I trauma center: the argument for injury prevention. J Trauma 2003; 54:66-70; discussion-1
66. Rixen D, Raum M, Bouillon B, Schlosser LE, Neugebauer E: Predicting the outcome in severe injuries: an analysis of 2069 patients from the trauma register of the German Society of Traumatology (DGU). Unfallchirurg 2001; 104:230-239
67. Peng R, Chang C, Gilmore D, Bongard F: Epidemiology of immediate and early trauma deaths at an urban Level I trauma center. Am Surg 1998; 64:950-954
68. Acosta JA, Yang JC, Winchell RJ, Simons RK, Fortlage DA, Hollingsworth-Fridlund P, Hoyt DB: Lethal injuries and time to death in a level I trauma center. J Am Coll Surg 1998; 186:528-533
69. Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, Pons PT: Epidemiology of trauma deaths: a reassessment. J Trauma 1995; 38:185-193
70. Croce MA, Tolley EA, Claridge JA, Fabian TC: Transfusions result in pulmonary morbidity and death after a moderate degree of injury. J Trauma 2005; 59:19-24
71. Davenport RD: Pathophysiology of hemolytic transfusion reactions. Semin Hematol 2005; 42:165-168
72. Armand R, Hess JR: Treating coagulopathy in trauma patients. Transfus Med Rev 2003; 17:223-231
73. Dzik WH: Predicting hemorrhage using preoperative coagulation screening assays. Curr Hematol Rep 2004; 3:324-330
74. Hirshberg A, Dugas M, Banez EI, Scott BG, Wall MJ Jr, Mattox KL: Minimizing dilutional coagulopathy in exsanguinating hemorrhage: a computer simulation. J Trauma 2003; 54:454-463
75. Hamilton SM: The use of blood in resuscitation of the trauma patient. Can J Surg 1993; 36:21-27
76. Edna TH, Bjerkeset T: Association between blood transfusion and infection in injured patients. J Trauma 1992; 33:659-661
77. Claridge JA, Sawyer RG, Schulman AM, McLemore EC, Young JS: Blood transfusions correlate with infections in trauma patients in a dose-dependent manner. Am Surg 2002; 68:566-572
78. Hughes MG, Evans HL, Lightfoot L, Chong TW, Smith RL, Raymond DP, Pelletier SJ, Claridge JA, Pruett TL, Sawyer RG: Does prior transfusion worsen outcomes from infection in surgical patients? Surg Infect (Larchmt) 2003; 4:335-343
79. Croce MA, Tolley EA, Claridge JA, Fabian TC: Transfusions result in pulmonary morbidity and death after a moderate degree of injury. J Trauma 2005; 59:19-23; discussion -4
80. Vamvakas EC, Blajchman MA: Deleterious clinical effects of transfusion-associated immunomodulation: fact or fiction? Blood 2001; 97:1180-1195
81. Silliman CC, Moore EE, Johnson JL, Gonzalez RJ, Biffl WL: Transfusion of the injured patient: proceed with caution. Shock 2004; 21:291-299
82. Criddle LM, Eldredge DH, Walker J: Variables predicting trauma patient survival following massive transfusion. J Emerg Nurs 2005; 31:236-242; quiz 320
83. Hakala P, Lindahl J, Alberty A, Tanskanen P, Nieminen H, Porras M: Massive transfusion exceeding 150 units of packed red cells during the first 15 hours after injury. J Trauma 1998; 44:410-412