The hazards of moist toilet paper: Allergy to the preservative methylchloroisothiazolinone/methylisothiazolinone

Archives of Dermatology

Volumn 146, Issue 8, 2010, Pages 886-890

  Gardner, Kevin H ^a   Davis, Mark D P ^a   Richardson, Donna M ^a   Pittelkow, Mark R ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 4 ISOTHIAZOLIN 3 ONE; 5 CHLORO 2 METHYL 4 ISOTHIAZOLIN 3 ONE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CLOBETASOL PROPIONATE; CORTICOSTEROID; DESONIDE; FLUCONAZOLE; MAGNESIUM SULFATE; METHOTREXATE; NYSTATIN; TRIAMCINOLONE; TRYPSIN; ZINC OXIDE; 2-METHYL-4-ISOTHIAZOLIN-3-ONE; 5-CHLORO-2-METHYL-4-ISOTHIAZOLIN-3-ONE; PRESERVATIVE; THIAZOLE DERIVATIVE;

ADULT; AGED; ARTICLE; CASE REPORT; FEMALE; HUMAN; HUMAN TISSUE; LIVER TOXICITY; MALE; MOISTURE; PAIN; PAIN ASSESSMENT; PAPULE; PATCH TEST; PERIANAL GLAND; PERINEUM; PERSONAL HYGIENE; PHYSICAL EXAMINATION; PITYRIASIS RUBRA PILARIS; PRIORITY JOURNAL; PRURITUS; RASH; SKIN ALLERGY; SKIN IRRITATION; SKIN PRURITUS; TOILET PAPER; TREATMENT RESPONSE; ANUS DISEASES; DERMATITIS, ALLERGIC CONTACT; MIDDLE AGED; PAPER; PATHOLOGY;

ADULT; AGED; ANUS DISEASES; DERMATITIS, ALLERGIC CONTACT; FEMALE; HUMANS; MALE; MIDDLE AGED; PAPER; PERINEUM; PRESERVATIVES, PHARMACEUTICAL; THIAZOLES;

EID: 77955866437     PISSN: 0003987X     EISSN: 15383652     Source Type: Journal    
DOI: 10.1001/archdermatol.2010.114     Document Type: Article

References (14)

1. Mowad CM. Methylchloro-isothiazolinone revisited. Am J Contact Dermat. 2000; 11(2):115-118.
2. Lundov MD, Moesby L, Zachariae C, Johansen JD. Contamination versus preservation of cosmetics: a review on legislation, usage, infections, and contact allergy. Contact Dermatitis. 2009;60(2):70-78.
3. Maier LE, Lampel HP, Bhutani T, Jacob SE. Hand dermatitis: a focus on allergic contact dermatitis to biocides. Dermatol Clin. 2009;27(3):251-264, v-vi.
4. Zug KA, Warshaw EM, Fowler JF Jr, et al. Patch-test results of the North American Contact Dermatitis Group 2005-2006. Dermatitis. 2009;20(3): 149-160.
5. Davis MD, Scalf LA, Yiannias JA, et al. Changing trends and allergens in the patch test standard series: a Mayo Clinic 5-year retrospective review, January 1, 2001, through December 31, 2005. Arch Dermatol. 2008;144(1):67-72.
6. Hogan DJ. Allergic contact dermatitis (ACD) to methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) in a flushable moist wipe [abstract]. Dermatitis. 2009;20(4):229.
7. Timmermans A, De Hertog S, Gladys K, Vanacker H, Goossens A. 'Dermatologically tested' baby toilet tissues: a cause of allergic contact dermatitis in adults. Contact Dermatitis. 2007;57(2):97-99.
8. Fields KS, Nelson T, Powell D. Contact dermatitis caused by baby wipes. J Am Acad Dermatol. 2006;54(5, suppl):S230-S232.
9. Tosti A, Voudouris S, Pazzaglia M. Contact sensitization to 5-chloro-2-methyl- 4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one in children. Contact Dermatitis. 2003;49(4):215-216.
10. Guin JD, Kincannon J, Church FL. Baby-wipe dermatitis: preservative-induced hand eczema in parents and persons using moist towelettes.AmJ Contact Dermat. 2001;12(4):189-192.
11. de Groot AC. Vesicular dermatitis of the hands secondary to perianal allergic contact dermatitis caused by preservatives in moistened toilet tissues. Contact Dermatitis. 1997;36(3):173-174.
12. Guimaraens D, Conde-Salazar L, Gonzalez MA. Allergic contact dermatitis on the hands from chloromethylisothiazolinone inmoist toilet paper. Contact Dermatitis. 1996;35(4):254.
13. de Groot AC, Baar TJ, Terpstra H, Weyland JW. Contact allergy to moist toilet paper. Contact Dermatitis. 1991;24(2):135-136.
14. Minet A, Eggers S, Willocx D, Bourlond A, Lachapelle JM. Allergic contact dermatitis from Kathon CG in moist toilet paper. Contact Dermatitis. 1989;21(2): 107-108.