Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K2 is associated with p53 and independent of the intrinsic apoptotic pathway

Molecular and Cellular Biochemistry

Volumn 342, Issue 1-2, 2010, Pages 125-131

  Li, Lu ^a,b   Qi, Zhiling ^a   Qian, Jin ^b   Bi, Fuyong ^a   Lv, Jun ^a   Xu, Lei ^a   Zhang, Ling ^a   Chen, Hongyu ^b   Jia, Renbing ^b  

^a WANNAN MEDICAL COLLEGE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Intrinsic apoptotic pathway; p53; Smmc 7721 cells; Vitamin K2

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; FARNOQUINONE; MESSENGER RNA; PROTEIN P53;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG MECHANISM; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LIVER CELL CARCINOMA; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CASPASE 8; CASPASE 9; CELL PROLIFERATION; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMANS; LIVER NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53; VITAMIN K 2; VITAMINS;

EID: 77955851458     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-010-0476-8     Document Type: Article

References (30)

1. 2 and enhancement by MEK inhibition Int J Oncol 29 1501 1508 1:CAS:528:DC%2BD2sXhvVOlsw%3D%3D 17088989
2. 2) by intestinal bacteria and their role in maintaining coagulation homeostasis Prog Food Nutr Sci 16 307 343 1:STN:280:DyaK3s7ltVWmsA%3D%3D 1492156
3. 2 (menaquinone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis J Bone Miner Res 15 515 521 10.1359/jbmr.2000.15.3.515 1:CAS:528:DC%2BD3cXitFaktrc%3D 10750566
4. K Miyazawa M Yaguchi K Funato, et al. 2001 Apoptosis/differentiation- inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells Leukemia 15 1111 1117 10.1038/sj.leu.2402155 1:CAS:528:DC%2BD3MXlvVKjt70%3D 11455981 (Pubitemid 32717282)
5. T Yokoyama K Miyazawa T Yoshida, et al. 2005 Combination of vitamin K2 plus imatinib mesylate enhances induction of apoptosis in small cell lung cancer cell lines Int J Oncol 26 33 40 1:CAS:528:DC%2BD2MXmsFWjtw%3D%3D 15586222
6. T Sibayama-Imazu Y Fujisawa Y Masuda, et al. 2008 Induction of apoptosis in PA-1 ovarian cancer cells by vitamin K2 is associated with an increase in the level of TR3/Nur77 and its accumulation in mitochondria and nuclei J Cancer Res Clin Oncol 134 803 812 10.1007/s00432-007-0349-z 10.1007/s00432-007-0349-z 1:CAS:528:DC%2BD1cXlsFOktrY%3D 18202854
7. M Otsuka N Kato RX Shao, et al. 2004 Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation Hepatology 40 243 251 10.1002/hep.20260 10.1002/hep.20260 1:CAS:528: DC%2BD2cXmtlSgurc%3D 15239108 (Pubitemid 38868943)
8. T Yoshida K Miyazawa I Kasuga, et al. 2003 Apoptosis induction of vitamin K2 in lung carcinoma cell lines: the possibility of vitamin K2 therapy for lung cancer Int J Oncol 23 627 632 1:CAS:528:DC%2BD3sXntVCjsLs%3D 12888897
9. H Tokita A Tsuchida K Miyazawa, et al. 2006 Vitamin K2-induced antitumor effects via cell-cycle arrest and apoptosis in gastric cancer cell lines Int J Mol Med 17 235 243 1:CAS:528:DC%2BD28XhsVems7w%3D 16391821
10. K Azuma T Urano Y Ouchi, et al. 2009 Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor Endocr J 56 843 849 10.1507/endocrj.K09E-108 10.1507/endocrj.K09E-108 1:CAS:528:DC%2BC3cXlslOlsQ%3D%3D 19550077
11. T Yamamoto H Nakamura W Liu, et al. 2009 Involvement of hepatoma-derived growth factor in the growth inhibition of hepatocellular carcinoma cells by vitamin K2 J Gastroenterol 44 228 235 10.1007/s00535-008-2304-4 10.1007/s00535-008-2304-4 1:CAS:528:DC%2BD1MXhvVyqtLY%3D 19214667
12. JC Reed 2003 Apoptosis-targeted therapies for cancer Cancer Cell 3 17 22 10.1016/S1535-6108(02)00241-6 10.1016/S1535-6108(02)00241-6 1:CAS:528: DC%2BD3sXhtFamt7s%3D 12559172 (Pubitemid 37443888)
13. NA Thornberry Y Lazebnik 1998 Caspases: enemies within Science 281 1312 1316 10.1126/science.281.5381.1312 10.1126/science.281.5381.1312 1:CAS:528:DyaK1cXlvVegsLs%3D 9721091
14. HJ Brady 2003 Apoptosis and leukaemia Br J Haematol 123 577 585 10.1046/j.1365-2141.2003.04663.x 1:CAS:528:DC%2BD3sXpvF2itbY%3D 14616959 (Pubitemid 37468052)
15. HH Cheung V Arora RG Korneluk 2006 Abnormalities of cell structures in tumors: apoptosis in tumors EXS 96 201 221 1:CAS:528:DC%2BD28XktF2nug%3D%3D 16383020
16. DW Meek 2009 Tumour suppression by p53: a role for the DNA damage response? Nat Rev Cancer 9 714 723 10.1038/nrc2716 1:CAS:528:DC%2BD1MXhtVygsbbL 19730431
17. JN Wu J Huang 2008 Caspase inhibition augmented oridonin induced cell death in murine fibrosarcoma L929 by enhancing reactive oxygen species generation J Pharmacol Sci 108 32 39 10.1254/jphs.FP0072079 10.1254/jphs. FP0072079 1:CAS:528:DC%2BD1cXht1amtr%2FN 18818479
18. S Kalia MP Bansal 2009 Regulation of apoptosis by caspase under oxidative stress conditions in mice testicular cells: in vitro molecular mechanism Mol Cell Biochem 322 43 52 10.1007/s11010-008-9938-7 10.1007/s11010-008-9938-7 1:CAS:528:DC%2BD1MXhtVWhtrY%3D 18979186
19. DR Green G Kroemer 2004 The pathophysiology of mitochondrial cell death Science 305 626 629 10.1126/science.1099320 10.1126/science.1099320 1:CAS:528:DC%2BD2cXmtFWqsrc%3D 15286356 (Pubitemid 39006738)
20. K Cain SB Bratton C Langlais, et al. 2000 Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes J Biol Chem 275 6067 6070 10.1074/jbc.275.9.6067 10.1074/jbc.275.9.6067 1:CAS:528:DC%2BD3cXhslWrs74%3D 10692394 (Pubitemid 30129888)
21. X Saelens N Festjens L Vande Walle, et al. 2004 Toxic proteins released from mitochondria in cell death Oncogene 23 2861 2874 10.1038/sj.onc.1207523 10.1038/sj.onc.1207523 1:CAS:528:DC%2BD2cXivFKmsL0%3D 15077149 (Pubitemid 38638848)
22. MP Boldin EE Varfolomeev Z Pancer, et al. 1995 A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain J Biol Chem 270 7795 7798 10.1074/jbc.270.14.7795 10.1074/jbc.270.14.7795 1:CAS:528:DyaK2MXltVShsbc%3D 7536190
23. AM Chinnaiyan K O'Rourke M Tewari, et al. 1995 FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis Cell 81 505 512 10.1016/0092-8674(95)90071-3 10.1016/0092-8674(95) 90071-3 1:CAS:528:DyaK2MXlvVGgtbY%3D 7538907
24. FC Kischkel S Hellbardt I Behrmann, et al. 1995 Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor EMBO J 14 5579 5588 1:CAS:528:DyaK2MXpslamtr4%3D 8521815
25. MP Boldin TM Goncharov YV Goltsev, et al. 1996 Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death Cell 85 803 815 10.1016/S0092-8674(00)81265-9 10.1016/S0092-8674(00) 81265-9 1:CAS:528:DyaK28XjslSkurk%3D 8681376
26. M Muzio AM Chinnaiyan FC Kischkel, et al. 1996 FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex Cell 85 817 827 10.1016/S0092-8674(00)81266-0 10.1016/S0092-8674(00)81266-0 1:CAS:528:DyaK28XjslSkurY%3D 8681377 (Pubitemid 26193033)
27. M Muzio BR Stockwell HR Stennicke, et al. 1998 An induced proximity model for caspase-8 activation J Biol Chem 273 2926 2930 10.1074/jbc.273.5.2926 10.1074/jbc.273.5.2926 1:CAS:528:DyaK1cXnvFSkug%3D%3D 9446604 (Pubitemid 28133943)
28. Y Haupt R Maya A Kazaz, et al. 1997 Mdm2 promotes the rapid degradation of p53 Nature 387 296 299 10.1038/387296a0 10.1038/387296a0 1:CAS:528: DyaK2sXjtlSgtL8%3D 9153395 (Pubitemid 27220766)
29. S Haupt Y Haupt 2004 Improving cancer therapy through p53 management Cell Cycle 3 912 916 1:CAS:528:DC%2BD2MXmtlKquw%3D%3D 15254405
30. T Amano A Nakamizo SK Mishra, et al. 2009 Simultaneous phosphorylation of p53 at serine 15 and 20 induces apoptosis in human glioma cells by increasing expression of pro-apoptotic genes J Neurooncol 92 357 371 10.1007/s11060-009- 9844-1 10.1007/s11060-009-9844-1 1:CAS:528:DC%2BD1MXkt1yit7c%3D 19357962