Rifaximin in hepatic encephalopathy: More than just a non-absorbable antibiotic?

Journal of Hepatology

Volumn 53, Issue 3, 2010, Pages 580-582

  Jalan, Rajiv ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Ammonia; Hepatic Encephalopathy; Inflammation; Norfloxacin; Rifaximin

Indexed keywords

LACTULOSE; PLACEBO; RIFAXIMIN;

CHRONIC LIVER DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; HEPATIC ENCEPHALOPATHY; HOSPITALIZATION; HUMAN; INCIDENCE; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REMISSION; REVIEW; RISK REDUCTION; TREATMENT DURATION; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

EID: 77955847534     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.05.002     Document Type: Note

References (11)

1. P. Ferenci, A. Lockwood, K. Mullen, R. Tarter, K. Weissenborn, and A.T. Blei Hepatic encephalopathy-definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998 Hepatology 35 2002 716 721
2. P. Ginés, E. Quintero, V. Arroyo, J. Terés, M. Bruguera, and A. Rimola Compensated cirrhosis: natural history and prognostic factors Hepatology 7 1987 122 128
3. N.M. Bass, K.D. Mullen, A. Sanyal, F. Poordad, G. Neff, and C.B. Leevy Rifaximin treatment in hepatic encephalopathy N Engl J Med 362 2010 1071 1081
4. S. Johnson Recurrent Clostridium difficile infection: a review of risk factors, treatments, and outcomes J Infect 58 2009 403 410
5. J. Fernández, M. Navasa, R. Planas, S. Montoliu, D. Monfort, and G. Soriano Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis Gastroenterology 133 2007 818 824
6. Q. Liu, Z.P. Duan, D.K. Ha, S. Bengmark, J. Kurtovic, and S.M. Riordan Symbiotic modulation of gut flora: effect on minimal hepatic encephalopathy in patients with cirrhosis Hepatology 39 2004 1441 1449
7. M. Hiraishi, T. Takahama, Z. Yamazaki, F. Kanai, K. Ohnishi, and Y. Idezuki Effect of oral adsorbent on blood metabolites in hepatic failure dogs Int J Artif Organs 12 1989 114 120
8. D. Shawcross, and R. Jalan The pathophysiologic basis of hepatic encephalopathy: central role for ammonia and inflammation Cell Mol Life Sci 62 2005 2295 2304
9. R. Jalan, S.W. Olde Damink, P.C. Hayes, N.E. Deutz, and A. Lee Pathogenesis of intracranial hypertension in acute liver failure: inflammation, ammonia and cerebral blood flow J Hepatol 41 2004 613 620
10. N.A. Davies, G. Wright, L.M. Ytrebø, V. Stadlbauer, O.M. Fuskevg, and C. Zwingmann l-ornithine and phenylacetate synergistically produce sustained reduction in ammonia and brain water in cirrhotic rats Hepatology 50 2009 155 164
11. G. Wright, and R. Jalan Ammonia and inflammation in the pathogenesis of hepatic encephalopathy: Pandora's box? Hepatology 46 2007 291 294 (Pubitemid 47344761)