A sensitive and selective liquid chromatography/tandem mass spectrometry method for determination of MLN8237 in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 25, 2010, Pages 2369-2373

  Lipsitz, Emily ^a   Moorthy, Ganesh ^a   Mosse, Yael ^a   Fox, Elizabeth ^a   Adamson, Peter C ^a  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Cancer; LC ESI CID MS MS; MLN8237; Pediatric; Plasma

Indexed keywords

ANALYTICAL METHOD; AURORA-A KINASE; CANCER; COLLISION INDUCED DISSOCIATION; HIGHLY SENSITIVE; HUMAN PLASMAS; LC-ESI-CID-MS/MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; MLN8237; PHASE 1; SAMPLE PREPARATION; SPRAY IONIZATION; STABILITY STUDY; STANDARD DEVIATION; TANDEM MASS SPECTROMETRY;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; LIQUIDS; MASS SPECTROMETRY; PEDIATRICS; PLASMA (HUMAN);

PLASMAS;

AURORA KINASE INHIBITOR; MLN 8237; SODIUM 4 [[9 CHLORO 7 (2 FLUORO 6 METHOXYPHENYL) 5H PYRIMIDO [5,4 D] BENZAZEPIN 2 YL]AMINO] 2 METHOXYBENZOATE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; COLLISIONALLY ACTIVATED DISSOCIATION; DRUG STABILITY; ELECTROSPRAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY;

AZEPINES; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; HUMANS; LEAST-SQUARES ANALYSIS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY;

EID: 77955847169     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.06.037     Document Type: Article

References (6)

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