Periodontal healing and bone regeneration in response to azithromycin

Australian Dental Journal

Volumn 55, Issue 2, 2010, Pages 193-199

  Hirsch, R ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Azithromycin; Bone regeneration; Periodontal healing; Periodontitis

Indexed keywords

ANTIINFECTIVE AGENT; AZITHROMYCIN;

ADULT; AGED; AGGRESSIVE PERIODONTITIS; ALVEOLAR BONE LOSS; ARTICLE; BONE REGENERATION; CASE REPORT; CHRONIC PERIODONTITIS; DRUG EFFECT; FEMALE; FOLLOW UP; GINGIVA OVERGROWTH; GINGIVITIS; HUMAN; MALE; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; NON INSULIN DEPENDENT DIABETES MELLITUS; PERIODONTAL DISEASE; PERIODONTAL POCKET; PERIODONTICS;

ADULT; AGED; AGGRESSIVE PERIODONTITIS; ALVEOLAR BONE LOSS; ANTI-BACTERIAL AGENTS; AZITHROMYCIN; BONE REGENERATION; CHRONIC PERIODONTITIS; COMBINED MODALITY THERAPY; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; FURCATION DEFECTS; GINGIVAL OVERGROWTH; GINGIVITIS; HUMANS; MALE; MIDDLE AGED; PERIODONTAL POCKET; SUBGINGIVAL CURETTAGE; TOOTH MOBILITY;

EID: 77955826479     PISSN: 00450421     EISSN: 18347819     Source Type: Journal    
DOI: 10.1111/j.1834-7819.2010.01227.x     Document Type: Article

References (33)

1. Heitz-Mayfield LJ. Systemic antibiotics in periodontal therapy. Aust Dent J 2009;54(1 Suppl):S96-S101.
2. Herrera D, Alonso B, Leon R, Roldan S, Sanz M. Antimicrobial therapy in periodontitis: the use of systemic antimicrobials against the subgingival biofilm. J Clin Periodontol 2008;35:45-66.
3. Chico RM, Pittrof R, Greenwood B, Chandramohan D. Azithromycinchloroquine and the intermittent preventive treatment of malaria in pregnancy. Malar J 2008;7:255.
4. Hoepelman IM, Schneider MM. Azithromycin: the first of the tissueselective azalides. Int J Antimicrob Agents 1995;5:145-167.
5. Solomon AW, Holland MJ, Alexander ND, et al. Mass treatment with single-dose azithromycin for trachoma. N Engl J Med 2004;351:1962-1971.
6. Gomi K, Yashima A, Iino F, et al. Drug concentration in inflamed periodontal tissues after systemically administered azithromycin. J Periodontol 2007;78:918-923.
7. Tamura A, Ara T, Imamura Y, Fujii T, Wang PL. The effects of antibiotics on in vitro biofilm model of periodontal disease. Eur J Med Res 2008;13:439-445.
8. Foulds G, Shepard RM, Johnson RB. The pharmacokinetics of azithromycin in human serum and tissues. J Antimicrob Chemother 1990;25 Suppl A:73-82.
9. Blandizzi C, Malizia T, Lupetti A, et al. Periodontal tissue disposition of azithromycin in patients affected by chronic inflammatory periodontal diseases. J Periodontol 1999;70:960-966.
10. Glasheen JJ, Fugit RV, Prochazka AV. The risk of overanticoagulation with antibiotic use in outpatients on stable warfarin regimens. J Gen Intern Med 2005;20:653-656.
11. Amsden GW. Anti-inflammatory effects of macrolides-an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions? J Antimicrob Chemother 2005;55:10-21.
12. McDonald PJ, Pruul H. Phagocyte uptake and transport of azithromycin. Eur J Clin Microbiol Infect Dis 1991;10:828-833.
13. Bosnar M, Kelneric Z, Munic V, Erakovic V, Parnham MJ. Cellular uptake and efflux of azithromycin, erythromycin, clarithromycin, telithromycin, and cethromycin. Antimicrob Agents Chemother 2005;49:2372-2377.
14. Tamaoki J. The effects of macrolides on inflammatory cells. Chest 2004;125:S41-S50.
15. McDonald PJ, Pruul H. Macrolides and the immune system. Scand J Infect Dis Suppl 1992;83:34-40.
16. Hodge S, Hodge G, Brozyna S, Jersmann H, Holmes M, Reynolds PN. Azithromycin increases phagocytosis of apoptotic bronchial epithelial cells by alveolar macrophages. Eur Respir J 2006;28: 486-495.
17. Bosnar M, Bosnjak B, Cuzic S, et al. Azithromycin and clarithromycin inhibit lipopolysaccharide-induced murine pulmonary neutrophilia mainly through effects on macrophage-derived granulocyte-macrophage colony-stimulating factor and interleukin1beta. J Pharmacol Exp Ther 2009;331:104-113.
18. Tokgoz B, Sari HI, Yildiz O, et al. Effects of azithromycin on cyclosporine-induced gingival hyperplasia in renal transplant patients. Transplant Proc 2004;36:2699-2702.
19. Wahlstrom E, Zamora JU, Teichman S. Improvement in cyclosporineassociated gingival hyperplasia with azithromycin therapy. N Engl J Med 1995;332:753-754.
20. Wirnsberger GH, Pfragner R, Mauric A, Zach R, Bogiatzis A, Holzer H. Effect of antibiotic treatment with azithromycin on cyclosporine A-induced gingival hyperplasia among renal transplant recipients. Transplant Proc 1998;30:2117-2119.
21. Smith SR, Foyle DM, Daniels J, et al. A double-blind placebocontrolled trial of azithromycin as an adjunct to non-surgical treatment of periodontitis in adults: clinical results. J Clin Periodontol 2002;29:54-61.
22. Gomi K, Yashima A, Nagano T, Kanazashi M, Maeda N, Arai T. Effects of full-mouth scaling and root planing in conjunction with systemically administered azithromycin. J Periodontol 2007;78: 422-429.
23. Haffajee AD, Patel M, Socransky SS. Microbiological changes associated with four different periodontal therapies for the treatment of chronic periodontitis. Oral Microbiol Immunol 2008;23:148-157.
24. Haffajee AD, Torresyap G, Socransky SS. Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results. J Clin Periodontol 2007;34: 243-253.
25. Mascarenhas P, Gapski R, Al-Shammari K, et al. Clinical response of azithromycin as an adjunct to non-surgical periodontal therapy in smokers. J Periodontol 2005;76:426-436.
26. Pradeep AR, Sagar SV, Daisy H. Clinical and microbiologic effects of subgingivally delivered 0.5% azithromycin in the treatment of chronic periodontitis. J Periodontol 2008;79:2125-2135.
27. Yashima A, Gomi K, Maeda N, Arai T. One-stage full-mouth versus partial-mouth scaling and root planing during the effective half-life of systemically administered azithromycin. J Periodontol 2009;80:1406-1413.
28. Lopez NJ, Socransky SS, Da Silva I, Japlit MR, Haffajee AD. Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. J Clin Periodontol 2006;33:648-660.
29. Mombelli A. Heresy? Treatment of chronic periodontitis with systemic antibiotics only. J Clin Periodontol 2006;33:661-662.
30. Moskow BS, Tannenbaum P. Enhanced repair and regeneration of periodontal lesions in tetracycline-treated patients. Case reports. J Periodontol 1991;62:341-350.
31. Preshaw PM, Hefti AF, Jepsen S, Etienne D, Walker C, Bradshaw MH. Subantimicrobial dose doxycycline as adjunctive treatment for periodontitis. A review. J Clin Periodontol 2004;31:697-707.
32. Labro M-T. Influence of antibacterial drugs on the immune system. In: Nijkamp F, Parnham M, eds. Principles of Immunopharmacology. 2nd edn. Basel: Birkhä user, 2000:407-439.
33. Kim JY, Park SH, Cho KS, et al. Mechanism of azithromycin treatment on gingival overgrowth. J Dent Res 2008;87:1075-1079.