Bone marrow derived cells in the tumour microenvironment contain cells with primitive haematopoietic phenotype

Journal of Cellular and Molecular Medicine

Volumn 14, Issue 7, 2010, Pages 1946-1952

  Deak, Erika ^a,b   Göttig, Stephan ^a   Rüster, Brigitte ^a   Paunescu, Virgil ^b   Seifried, Erhard ^a   Gille, Jens ^a   Henschler, Reinhard ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Department of Immunology University 'Victor Babes' ^*  (Romania)

Author keywords

Colony forming cells; Haematopoietic progenitor cells; Homing; Tumour

Indexed keywords

ANIMAL; ARTICLE; BONE MARROW CELL; CYTOLOGY; HEMATOPOIESIS; MOUSE; PHENOTYPE;

ANIMALS; BONE MARROW CELLS; HEMATOPOIESIS; MICE; PHENOTYPE;

ANIMALIA; MURINAE; MUS;

EID: 77955816608     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00908.x     Document Type: Article

References (21)

1. Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med. 1971, 285:1182-6.
2. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during angiogenesis. Cell. 1996, 86:353-64.
3. Risau W. Mechanisms of angiogenesis. Nature. 1997, 386:671-4.
4. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature. 2000, 407:249-57.
5. Lyden D, Hattori K, Dias S. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med. 2001, 7:1194-201.
6. Rafii S, Lyden D, Benezra R. Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy. Nat Rev Cancer. 2002, 2:826-35.
7. De Palma M, Vennert MA, Galli R. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell. 2005, 8:211-26.
8. Asahara T, Murohara T, Sullivan A. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997, 275:964-7.
9. Ruzinova MB, Schoer RA, Gerald W. Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors. Cancer Cell. 2003, 4:277-89.
10. Jin H, Aiyer A, Su J. A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature. J. Clin. Invest 2006, 116:652-62.
11. Christensen JL, Weissman IL. Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci USA. 2001, 98:14541-6.
12. Passegué E, Jamieson CH, Ailles LE, Weissman IL. Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics. Proc Natl Acad Sci USA. 2003, 100:11842-9.
13. Dumont DJ, Gradwohl GJ, Fong GH. The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors. Oncogene. 1993, 8:1293-301.
14. Arai F, Hirao A, Ohmura M. Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche. Cell. 2004, 118:149-61.
15. De Palma M, Venneri MA, Roca C. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat Med. 2003, 9:789-95.
16. Asahara T, Masuda H, Takahashi T. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res. 1999, 85:221-8.
17. Davidoff AM, Ng CY, Brown P. Bone marrow-derived cells contribute to tumor neovasculature and, when modified to express an angiogenesis inhibitor, can restrict tumor growth in mice. Clin Cancer Res. 2001, 7:2870-9.
18. Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med. 2003, 9:702-12.
19. Reyes M, Dudek A, Jahagirdar B. Origin of endothelial progenitors in human postnatal bone marrow. J Clin Invest. 2002, 109:337-46.
20. Nolan DJ, Ciarrocchi A, Mellick AS. Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. Genes Dev. 2007, 21:1546-58.
21. Carmeliet P. Angiogenesis in health and disease. Nat Med. 2003, 9:653-60.