Characteristic properties of metabolism of the yeast Yarrowia lipolytica during the synthesis of α-ketoglutaric acid from ethanol

Microbiology

Volumn 79, Issue 4, 2010, Pages 450-455

  Ilchenko, A P ^a   Lysyanskaya, V Ya ^a   Finogenova, T V ^a   Morgunov, I G ^a  

^a SKRYABIN INSTITUTE OF BIOCHEMISTRY AND PHYSIOLOGY OF MICROORGANISMS   (Russian Federation)

Author keywords

ketoglutaric acid; aminobutyric acid; free amino acids of a cell; succinate; succinyl semialdehyde; TCA cycle; transaminases; yeasts

Indexed keywords

YARROWIA LIPOLYTICA;

EID: 77955816607     PISSN: 00262617     EISSN: None     Source Type: Journal    
DOI: 10.1134/S0026261710040065     Document Type: Article

References (22)

1. Il'chenko, A. P., Chernyavskaya, O. G., Shishkanova, N. V., and Finogenova, T. V., Biochemical Characterization of the Yeast Yarrowia lipolytica Overproducing Carboxylic Acids from Ethanol: Nitrogen Metabolism Enzymes, Mikrobiologiya, 2003, vol. 72, no. 4, pp. 470-475 [Microbiology (Engl. Transl.), vol. 72, no. 4, pp. 418-422].
2. Rozenfel'd, S. M., Adanin, V. M., Zyakun, A. M., Grishchenko, V. M., and Disler, E. N., γ-Aminobutyric Acid in Thiamin-Heterotrophic Yeast Candida lipolytica, Mikrobiol. Prom-st., 1971, no. 1, pp. 20-22.
3. Der Garabedian, P. A., Lotti, A.-M., Vermeersch, J. J., 4-Aminobutyrate: 2-Oxoglutarate Aminotransferase from Candida. Purification and properties, Eur. J. Biochem., 1986, vol. 156, no. 3, pp. 589-596.
4. Ramos, F., Guezzar, M. E., Grenson, M., and Wiame, J.-M., Mutations Affecting the Enzymes Involved in the Utilization of 4-Aminobutyric Acid as Nitrogen Source by the Yeast S. cerevisiae, Eur. J. Biochem., 1995, vol. 149, no. 2, pp. 401-404.
5. Breitkreuz, K. E., Shelp, B. J., Fischer, W. N., Schwacke, R., and Rentsch, D., Identification and Characterization of GABA, Proline and Quaternary Ammonium Compound Transporters from Arabidopsis thaliana, FEBS Lett., 1999, vol. 450, no. 3, pp. 280-284.
6. Coleman, S. T., Fang, T. K., Rovinsky, S. A., Turano, F. J., and Moye-Rowley, W. S., Expression of a Glutamate Decarboxylase Homologue Is Required for Normal Oxidative Stress Tolerance in Saccharomyces cerevisiae, J. Biol. Chem., 2001, vol. 276, no. 1, pp. 244-250.
7. Masuda, K., Guo, X., Uryu, N., Hagiwara, T., and Watabe, S., Isolation of Marine Yeasts Collected from the Pacific Ocean Showing a High Production of γ-Aminobutyric Acid, Boisci. Biotechnol. Biochem., 2008, vol. 72, pp. 3265-3272.
8. Shelp, B. J., Bown, A. W., and McLean, M. D., Metabolism and Functions of Gamma-Aminobutyric Acid, Trends Plant Sci., 1999, vol. 4, no. 11, pp. 446-452.
9. Breitkreuz, K. E., Allan, W. L., van Cauwenberghe, O. R., Jakobs, C., Talibi, D., Andre, B., and Shelp, B. J., A Novel Gamma-Hydroxybutyrate Dehydrogenase Identification and Expression of an Arabidopsis cDNA and Potential Role Under Oxygen Deficiency, J. Biol. Chem., 2003, vol. 278, no. 42, pp. 41552-41556.
10. Sherwin, A. L., Neuroactive Amino Acids in Focally Epileptic Human Brain: a Review, Neurochem. Res., 1999, vol. 24, no. 11, pp. 1387-1395.
11. Nisbet, A. P., Eve, D. J., Kingsbury, A. E., Daniel, S. E., Marsden, C. D., Lees, A. J., and Foster, O. J., Glutamate Decarboxylase-67 Messenger RNA Expression in Normal Human Basal Ganglia and in Parkinson's Disease, Neuroscience, 1996, vol. 75, no. 2, pp. 389-406.
12. Ramos, E. and Batlle, A., Delta-Aminolevulinic Acid Uptake Is Mediated by the Gamma-Aminobutyric Acid-Specific Permease UGA4, Cell Mol. Biol., 1996, vol. 42, no. 4, pp. 519-523.
13. Garcia, S. C., Moretti, M. B., and Batlle, A., Constitutive Expression of the UGA4 Gene in Saccharomyces cerevisiae Depends on Two Positive-Acting Proteins, Uga3p and Uga35p, FEMS Microbiol. Letts., 2000, vol. 184, no. 2, pp. 219-224.
14. Chernyavskaya, O. G., Shishkanova, N. V., and Finogenova, T. V., Biosynthesis of α-Ketoglutaric Acid from Ethanol by Yeasts, Prikl. Biokhim. Mikrobiol., 1997, vol. 33, no. 3, pp. 296-300 [Appl. Biochem. Microbiol. (Engl. Transl.), vol. 33, no. 3, pp. 261-265].
15. Chernyavskaya, O. G., Shishkanova, N. V., Il'chenko, A. P., and Finogenova, T. V. Synthesis of α-Ketoglutaric Acid by Yrrowia lipolytica Yeast Grown on Ethanol, Appl. Microbiol. Biotechnol., 2000, vol. 53, no. 5, pp. 152-158.
16. 2] on Yeast Respiration and Acidogenesis, Mikrobiologiya, 2001, vol. 70, no. 2, pp. 189-195 [Microbiology (Engl. Transl.), vol. 70, no. 2, pp. 151-157].
17. Il'chenko, A. P. and Shcherbakova, V. A., Effect of Vitamin Concentration on the Synthesis of Lactate, Ethanol, Pyruvate, and Ethyl Acetate in Cells of the Yeast Dipodascus magnusii, Mikrobiologiya, 2008, vol. 77, no. 4, pp. 1-7 [Microbiology (Engl. Transl.), vol. 77, no. 4, pp. 430-435].
18. Spackman, D. H., Stein, W. H., and Moore, S., Chromatography of Amino Acids on Sulfonated Polystyrene Resins, Anal. Chem., 1958, vol. 30, no. 7, pp. 1185-1189.
19. Il'chenko, A. P., Chernyavskaya, O. G., Shishkanova, N. V., and Finogenova, T. V., Metabolism of Yarrowia lipolytica Grown on Ethanol under Conditions Promoting the Production of α-Ketoglutaric and Citric Acids: A Comparative Study of the Central Metabolism Enzymes, Mikrobiologiya, 2002, vol. 71, no. 3, pp. 316-322 [Microbiology (Engl. Transl.), vol. 71, no. 3, pp. 269-274].
20. Roberts, E., Disinhibition as an Organizing Principle in the Nervous System. The Role of Gamma-Aminobutyric Acid, Adv. Neurol., 1974, vol. 4, pp. 127-143.
21. 2 Fixation Pathway of the Archaeon Ignicoccus hospitalis: Comprehensive Analysis of the Central Carbon Metabolism, J. Bacteriol., 2007, vol. 189, no. 11, pp. 4108-4119.
22. Il'chenko, A. P., Chernyavskaya, O. G., Shishkanova, N. V., and Finogenova, T. V., Carboxylation Reactions Involved in Metabolism of Ethanol and Synthesis of Organic Acids in Yeast Yarrowia lipolytica, Int. Spec. Symposium on Yeast (ISSY, 2001).