Depletion of the oncoprotein Bcl-3 induces centrosome amplification and aneuploidy in cancer cells

Molecular Cancer

Volumn 9, Issue , 2010, Pages

  Zamora, Ruben ^a,d   Espinosa, Magali ^b   Ceballos Cancino, Gisela ^b   Segura, Blanca ^c,d   Maldonado, Vilma ^d   Melendez Zajgla, Jorge ^b,d  

^a Biotechnology Unit   (Mexico)

^b INSTITUTO NACIONAL DE MEDICINA GENÓMICA   (Mexico)

^c Gene Therapy Laboratory   (Mexico)

^d INSTITUTO NACIONAL DE CANCEROLOGÍA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CHECKPOINT KINASE 1; CYCLIN B; CYCLIN D1; CYCLIN DEPENDENT KINASE 1; HISTONE H2AX; I KAPPA B; NUCLEOLIN; ONCOPROTEIN; PROTEIN BCL 3; PROTEIN P53; SHORT HAIRPIN RNA; PROTO ONCOGENE PROTEIN BCL 3; PROTO-ONCOGENE PROTEIN BCL-3; TRANSCRIPTION FACTOR;

ANEUPLOIDY; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL SURVIVAL; CENTROSOME; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE ACTIVATION; GENE AMPLIFICATION; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; INHIBITION KINETICS; MULTINUCLEAR CELL; PLOIDY; PROMOTER REGION; PROTEIN DEPLETION; PROTEIN FAMILY; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; CELL CYCLE; GENE SILENCING; GENETICS; NEOPLASM; PATHOLOGY;

ANEUPLOIDY; CELL CYCLE; CENTROSOME; CYCLIN D1; GENE KNOCKDOWN TECHNIQUES; HELA CELLS; HUMANS; NEOPLASMS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTORS;

EID: 77955815973     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-9-223     Document Type: Article

References (20)

1. Crossen PE. Cytogenetic and molecular changes in chronic B-cell leukemia. Cancer Genet Cytogenet 1989, 43(2):143-150. 10.1016/0165-4608(89)90027-7, 2598162.
2. Ohno H, Takimoto G, McKeithan TW. The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 1990, 60(6):991-997. 10.1016/0092-8674(90)90347-H, 2180580.
3. Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell 1993, 72(5):729-739. 10.1016/0092-8674(93)90401-B, 8453667.
4. Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A. The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators. Oncogene 1999, 18(22):3316-3323. 10.1038/sj.onc.1202717, 10362352.
5. Fujita T, Nolan GP, Liou HC, Scott ML, Baltimore D. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers. Genes Dev 1993, 7(7B):1354-1363. 10.1101/gad.7.7b.1354, 8330739.
6. Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW. Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation. J Biol Chem 1999, 274(40):28491-28496. 10.1074/jbc.274.40.28491, 10497212.
7. Cogswell PC, Guttridge DC, Funkhouser WK, Baldwin AS. Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3. Oncogene 2000, 19(9):1123-1131. 10.1038/sj.onc.1203412, 10713699.
8. Thornburg NJ, Pathmanathan R, Raab-Traub N. Activation of nuclear factor-kappaB p50 homodimer/Bcl-3 complexes in nasopharyngeal carcinoma. Cancer Res 2003, 63(23):8293-8301.
9. Pallares J, Martinez-Guitarte JL, Dolcet X, Llobet D, Rue M, Palacios J, Prat J, Matias-Guiu X. Abnormalities in the NF-kappaB family and related proteins in endometrial carcinoma. J Pathol 2004, 204(5):569-577. 10.1002/path.1666, 15481028.
10. Westerheide SD, Mayo MW, Anest V, Hanson JL, Baldwin AS. The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition. Mol Cell Biol 2001, 21(24):8428-8436. 10.1128/MCB.21.24.8428-8436.2001, 100006, 11713278.
11. Massoumi R, Chmielarska K, Hennecke K, Pfeifer A, Fassler R. Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling. Cell 2006, 125(4):665-677. 10.1016/j.cell.2006.03.041, 16713561.
12. Kashatus D, Cogswell P, Baldwin AS. Expression of the Bcl-3 proto-oncogene suppresses p53 activation. Genes Dev 2006, 20(2):225-235. 10.1101/gad.1352206, 1356113, 16384933.
13. Dodson H, Bourke E, Jeffers LJ, Vagnarelli P, Sonoda E, Takeda S, Earnshaw WC, Merdes A, Morrison C. Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM. EMBO J 2004, 23(19):3864-3873. 10.1038/sj.emboj.7600393, 522792, 15359281.
14. Reinhardt HC, Yaffe MB. Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2. Curr Opin Cell Biol 2009, 21(2):245-255. 10.1016/j.ceb.2009.01.018, 2699687, 19230643.
15. Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003, 3(5):421-429. 10.1016/S1535-6108(03)00110-7, 12781359.
16. Brinkley BR. Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol 2001, 11(1):18-21. 10.1016/S0962-8924(00)01872-9, 11146294.
17. Meraldi P, Honda R, Nigg EA. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. EMBO J 2002, 21(4):483-492. 10.1093/emboj/21.4.483, 125866, 11847097.
18. Bourke E, Dodson H, Merdes A, Cuffe L, Zachos G, Walker M, Gillespie D, Morrison CG. DNA damage induces Chk1-dependent centrosome amplification. EMBO Rep 2007, 8(6):603-609. 10.1038/sj.embor.7400962, 2002539, 17468739.
19. Boulton SJ, Gartner A, Reboul J, Vaglio P, Dyson N, Hill DE, Vidal M. Combined functional genomic maps of the C. elegans DNA damage response. Science 2002, 295(5552):127-131. 10.1126/science.1065986, 11778048.
20. Watanabe N, Wachi S, Fujita T. Identification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination. J Biol Chem 2003, 278(28):26102-26110. 10.1074/jbc.M303518200, 12730195.