Bone destruction by invading oral squamous carcinoma cells mediated by the transforming growth factor-β signalling pathway

Anticancer Research

Volumn 30, Issue 7, 2010, Pages 2615-2623

  Goda, Takeshi ^a   Shimo, Tsuyoshi ^a   Yoshihama, Yasuto ^a,b   Hassan, Nur Mohammad Monsur ^a   Ibaragi, Soichiro ^a   Kurio, Naito ^a   Okui, Tatsuo ^a   Honami, Tatsuki ^a   Kishimoto, Koji ^a   Sasaki, Akira ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b SHOWA UNIVERSITY   (Japan)

Author keywords

Mandibular bone destruction; Osteoclast; TGF

Indexed keywords

[3 (PYRIDIN 2 YL) 4 (4 QUINONYL)] 1H PYRAZOLE; CONNECTIVE TISSUE GROWTH FACTOR; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN SERINE THREONINE KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DESTRUCTION; BONE METASTASIS; CANCER CELL CULTURE; CARCINOMA CELL; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MANDIBLE; MOLECULAR DYNAMICS; MOUSE; MOUTH CARCINOMA; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; UPREGULATION;

AGED; AGED, 80 AND OVER; ANIMALS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CONNECTIVE TISSUE GROWTH FACTOR; FEMALE; GENE EXPRESSION; GINGIVAL NEOPLASMS; HUMANS; MALE; MICE; MICE, NUDE; MIDDLE AGED; OSTEOLYSIS; PROTEIN-SERINE-THREONINE KINASES; RANK LIGAND; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TRANSPLANTATION, HETEROLOGOUS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955797385     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Brown JS, Lowe D, Kalavrezos N, D'Souza J, Magennis P and Woolgar J: Patterns of invasion and routes of tumor entry into the mandible by oral squamous cell carcinoma. Head Neck 24: 370-383, 2002. (Pubitemid 34260042)
2. Shaw RJ, Brown JS, Woolgar JA, Lowe D, Rogers SN and Vaughan ED: The influence of the pattern of mandibular invasion on recurrence and survival in oral squamous cell carcinoma. Head Neck 26: 861-869, 2004. (Pubitemid 39299305)
3. Massague J: TGFbeta in Cancer. Cell 134: 215-230, 2008.
4. Leask A and Abraham DJ: TGF-beta signalling and the fibrotic response. FASEB J 18: 816-827, 2004.
5. Bierie B and Moses HL: Transforming growth factor beta (TGF-beta) and inflammation in cancer. Cytokine Growth Factor Rev, 2009.
6. Massague J, Blain SW and Lo RS: TGFbeta signalling in growth control, cancer, and heritable disorders. Cell 103: 295-309, 2000.
7. Tan AR, Alexe G and Reiss M: Transforming growth factor-beta signalling: emerging stem cell target in metastatic breast cancer? Breast Cancer Res Treat 115: 453-495, 2009.
8. Mundy GR: Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer 2: 584-593, 2002.
9. Ge R, Rajeev V, Ray P, Lattime E, Rittling S, Medicherla S, Protter A, Murphy A, Chakravarty J, Dugar S, Schreiner G, Barnard N and Reiss M: Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res 12: 4315-4330, 2006.
10. Petersen M, Pardali E, van der Horst G, Cheung H, van den Hoogen C, van der Pluijm G and Ten Dijke P: Smad2 and Smad3 have opposing roles in breast cancer bone metastasis by differentially affecting tumor angiogenesis. Oncogene 29: 1351-1361, 2010.
11. Shinto O, Yashiro M, Kawajiri H, Shimizu K, Shimizu T, Miwa A and Hirakawa K: Inhibitory effect of a TGFbeta receptor type-I inhibitor, Ki26894, on invasiveness of scirrhous gastric cancer cells. Br J Cancer, 2010.
12. Brown JS, Griffith JF, Phelps PD and Browne RM: A comparison of different imaging modalities and direct inspection after periosteal stripping in predicting the invasion of the mandible by oral squamous cell carcinoma. Br J Oral Maxillofac Surg 32: 347-359., 1994.
13. Sasaki A, Boyce BF, Story B, Wright KR, Chapman M, Boyce R, Mundy GR and Yoneda T: Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice. Cancer Res 55: 3551-3557, 1995.
14. Shimo T, Kubota S, Yoshioka N, Ibaragi S, Isowa S, Eguchi T, Sasaki A and Takigawa M: Pathogenic role of connective tissue growth factor (CTGF/CCN2) in osteolytic metastasis of breast cancer. J Bone Miner Res 21: 1045-1059, 2006. (Pubitemid 43962833)
15. Bandyopadhyay A, Agyin JK, Wang L, Tang Y, Lei X, Story BM, Cornell JE, Pollock BH, Mundy GR and Sun LZ: Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor. Cancer Res 66: 6714-6721, 2006. (Pubitemid 44085629)
16. Ehata S, Hanyu A, Fujime M, Katsuno Y, Fukunaga E, Goto K, Ishikawa Y, Nomura K, Yokoo H, Shimizu T, Ogata E, Miyazono K, Shimizu K and Imamura T: Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line. Cancer Sci 98: 127-133, 2007. (Pubitemid 44803931)
17. Korpal M, Yan J, Lu X, Xu S, Lerit DA and Kang Y: Imaging transforming growth factor-beta signalling dynamics and therapeutic response in breast cancer bone metastasis. Nat Med 15: 960-966, 2009.
18. Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR and Massague J: TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133: 66-77, 2008. (Pubitemid 351442989)
19. Leivonen SK and Kahari VM: Transforming growth factor-beta signalling in cancer invasion and metastasis. Int J Cancer 121: 2119-2124, 2007. (Pubitemid 47585589)
20. Yoneda T and Hiraga T: Crosstalk between cancer cells and bone microenvironment in bone metastasis. Biochem Biophys Res Commun 328: 679-687, 2005. (Pubitemid 40208305)
21. Pfeilschifter J and Mundy GR: Modulation of transforming growth factor b activity in bone cultures by osteotrophic hormones. Proc Natl Acad Sci USA 84: 2024-2028, 1987. (Pubitemid 17054142)
22. Baselga J, Rothenberg ML, Tabernero J, Seoane J, Daly T, Cleverly A, Berry B, Rhoades SK, Ray CA, Fill J, Farrington DL, Wallace LA, Yingling JM, Lahn M, Arteaga C and Carducci M: TGF-beta signalling-related markers in cancer patients with bone metastasis. Biomarkers 13: 217-236, 2008. (Pubitemid 351250367)
23. Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordón-Cardo C, Guise TA and Massagué J: A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3: 537-549, 2003. (Pubitemid 36808649)
24. Shimo T, Kubota S, Goda T, Yoshihama Y, Kurio N, Nishida T, Ng PS, Endo K, Takigawa M and Sasakii A: Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma. Anticancer Res 28: 2343-2348, 2008.
25. Nozawa K, Fujishiro M, Kawasaki M, Kaneko H, Iwabuchi K, Yanagida M, Suzuki F, Miyazawa K, Takasaki Y, Ogawa H, Takamori K and Sekigawa I: Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. Arthritis Res Ther 11: R174, 2009.
26. Wittrant Y, Theoleyre S, Chipoy C, Padrines M, Blanchard F, Heymann D and Redini F: RANKL/RANK/OPG: new therapeutic targets in bone tumours and associated osteolysis. Biochim Biophys Acta 1704: 49-57, 2004. (Pubitemid 39195349)
27. Zhang J, Dai J, Yao Z, Lu Y, Dougall W and Keller ET: Soluble receptor activator of nuclear factor kappaB Fc diminishes prostate cancer progression in bone. Cancer Res 63: 7883-7890, 2003. (Pubitemid 37466723)
28. Balkwill F: TNF-alpha in promotion and progression of cancer. Cancer Metastasis Rev 25: 409-416, 2006.
29. Udagawa N, Takahashi N, Jimi E, Matsuzaki K, Tsurukai T, Itoh K, Nakagawa N, Yasuda H, Goto M, Tsuda E, Higashio K, Gillespie MT, Martin TJ and Suda T: Osteoblasts/stromal cells stimulate osteoclast activation through expression of osteoclast differentiation factor/RANKL but not macrophage colony-stimulating factor: receptor activator of NF-kappa B ligand. Bone 25: 517-523, 1999. (Pubitemid 29469457)