Effect of Tryptophan Hydroxylase-2 rs7305115 SNP on suicide attempts risk in major depression

Behavioral and Brain Functions

Volumn 6, Issue , 2010, Pages

  Zhang, Yuqi ^a   Zhang, Changsong ^b   Yuan, Guozhen ^a   Yao, Jianjun ^a   Cheng, Zaohuo ^a   Liu, Chaojun ^c   Liu, Qinghai ^c   Wan, Gairong ^c   Shi, Guizhi ^d   Cheng, Yiren ^c   Ling, Yang ^b   Li, Ke ^d  

^a NANJING MEDICAL UNIVERSITY   (China)

^b Ankang Hospital   (China)

^c SOOCHOW UNIVERSITY   (China)

^d SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TRYPTOPHAN HYDROXYLASE 2; TPH2 PROTEIN, HUMAN; TRYPTOPHAN HYDROXYLASE;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FAMILY HISTORY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HOPELESSNESS; HUMAN; LIFE EVENT; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PERSONALITY; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SUICIDE; SUICIDE ATTEMPT; ADOLESCENT; AGED; ALLELE; EMOTION; FAMILY HEALTH; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PSYCHOLOGICAL ASPECT;

ADOLESCENT; ADULT; AGED; ALLELES; DEPRESSIVE DISORDER, MAJOR; EMOTIONS; FAMILY HEALTH; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SUICIDE, ATTEMPTED; TRYPTOPHAN HYDROXYLASE;

EID: 77955796418     PISSN: 17449081     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-9081-6-49     Document Type: Article

References (32)

1. Li X, Xiao Z, Xiao S. Suicide among the elderly in mainland China. Psychogeriatrics 2009, 9:62-66. 10.1111/j.1479-8301.2009.00269.x, 19604327.
2. Witte TK, Timmons KA, Fink E, Smith AR, Joiner TE. Do major depressive disorder and dysthymic disorder confer differential risk for suicide?. J Affect Disord 2009, 115:69-78. 10.1016/j.jad.2008.09.003, 2674849, 18842304.
3. Roy A, Sarchiopone M, Carli V. Gene-environment interaction and suicidal behavior. J Psychiatr Pract 2009, 15:282-288. 10.1097/01.pra.0000358314.88931.b5, 19625883.
4. Arango V, Huang YY, Underwood MD, Mann JJ. Genetics of the serotonergic system in suicidal behavior. J Psychiatr Res 2003, 37:375-386. 10.1016/S0022-3956(03)00048-7, 12849930.
5. Anguelova M, Benkelfat C, Turecki G. A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry 2003, 8:646-653. 10.1038/sj.mp.4001336, 12874600.
6. Savelieva KV, Zhao S, Pogorelov VM, Rajan I, Yang Q, Cullinan E, Lanthorn TH. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One 2008, 3:e3301. 10.1371/journal.pone.0003301, 2565062, 18923670.
7. Mann JJ. Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology 1999, 21:99S-105S.
8. Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, Bader M. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 2003, 299:76. 10.1126/science.1078197, 12511643.
9. Patel PD, Pontrello C, Burke S. Robust and tissue-specific expression of TPH2 versus TPH1 in rat raphe and pineal gland. Biol Psychiatry 2004, 55:428-433. 10.1016/j.biopsych.2003.09.002, 14960297.
10. Cote F, Thevenot E, Fligny C, Fromes Y, Darmon M, Ripoche MA, Bayard E, Hanoun N, Saurini F, Lechat P, et al. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proc Natl Acad Sci USA 2003, 100:13525-13530. 10.1073/pnas.2233056100, 263847, 14597720.
11. Zhang X, Beaulieu JM, Sotnikova TD, Gainetdinov RR, Caron MG. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science 2004, 305:217. 10.1126/science.1097540, 15247473.
12. Zill P, Baghai TC, Zwanzger P, Schule C, Eser D, Rupprecht R, Moller HJ, Bondy B, Ackenheil M. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol Psychiatry 2004, 9:1030-1036. 10.1038/sj.mp.4001525, 15124006.
13. Scheuch K, Lautenschlager M, Grohmann M, Stahlberg S, Kirchheiner J, Zill P, Heinz A, Walther DJ, Priller J. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biol Psychiatry 2007, 62:1288-1294. 10.1016/j.biopsych.2007.01.015, 17568567.
14. Lopez de Lara C, Brezo J, Rouleau G, Lesage A, Dumont M, Alda M, Benkelfat C, Turecki G. Effect of tryptophan hydroxylase-2 gene variants on suicide risk in major depression. Biol Psychiatry 2007, 62:72-80. 10.1016/j.biopsych.2006.09.008, 17217922.
15. Chen GL, Vallender EJ, Miller GM. Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Hum Genet 2008, 122:645-657. 10.1007/s00439-007-0443-y, 2734478, 17972101.
16. Lin YM, Ko HC, Chang FM, Yeh TL, Sun HS. Population-specific functional variant of the TPH2 gene 2755C > A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women. Arch Womens Ment Health 2009, 12:401-408. 10.1007/s00737-009-0088-z, 19588223.
17. Leung CM, Wing YK, Kwong PK, Lo A, Shum K. Validation of the Chinese-Cantonese version of the hospital anxiety and depression scale and comparison with the Hamilton Rating Scale of Depression. Acta Psychiatr Scand 1999, 100:456-461. 10.1111/j.1600-0447.1999.tb10897.x, 10626925.
18. Williams JB. A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry 1988, 45:742-747.
19. Baca-Garcia E, Perez-Rodriguez MM, Basurte-Villamor I, Fernandez del Moral AL, Jimenez-Arriero MA, Gonzalez de Rivera JL, Saiz-Ruiz J, Oquendo MA. Diagnostic stability of psychiatric disorders in clinical practice. Br J Psychiatry 2007, 190:210-216. 10.1192/bjp.bp.106.024026, 17329740.
20. Spitzer RL, Wakefield JC. DSM-IV diagnostic criterion for clinical significance: does it help solve the false positives problem?. Am J Psychiatry 1999, 156:1856-1864.
21. Denning DG, Conwell Y, King D, Cox C. Method choice, intent, and gender in completed suicide. Suicide Life Threat Behav 2000, 30:282-288.
22. Wasserman D, Terenius L, Wasserman J, Sokolowski M. The 2009 Nobel conference on the role of genetics in promoting suicide prevention and the mental health of the population. Mol Psychiatry 2010, 15:12-17. 10.1038/mp.2009.113, 20029410.
23. Hawton K, van Heeringen K. Suicide. Lancet 2009, 373:1372-1381. 10.1016/S0140-6736(09)60372-X, 19376453.
24. Brezo J, Klempan T, Turecki G. The genetics of suicide: a critical review of molecular studies. Psychiatr Clin North Am 2008, 31:179-203. 10.1016/j.psc.2008.01.008, 18439443.
25. Bondy B, Buettner A, Zill P. Genetics of suicide. Mol Psychiatry 2006, 11:336-351. 10.1038/sj.mp.4001803, 16462816.
26. Invernizzi RW. Role of TPH-2 in brain function: news from behavioral and pharmacologic studies. J Neurosci Res 2007, 85:3030-3035. 10.1002/jnr.21330, 17492791.
27. Zhou Z, Roy A, Lipsky R, Kuchipudi K, Zhu G, Taubman J, Enoch MA, Virkkunen M, Goldman D. Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Arch Gen Psychiatry 2005, 62:1109-1118. 10.1001/archpsyc.62.10.1109, 16203956.
28. De Luca V, Mueller DJ, Tharmalingam S, King N, Kennedy JL. Analysis of the novel TPH2 gene in bipolar disorder and suicidality. Mol Psychiatry 2004, 9:896-897. 10.1038/sj.mp.4001531, 15197398.
29. De Luca V, Voineskos D, Wong GW, Shinkai T, Rothe C, Strauss J, Kennedy JL. Promoter polymorphism of second tryptophan hydroxylase isoform (TPH2) in schizophrenia and suicidality. Psychiatry Res 2005, 134:195-198. 10.1016/j.psychres.2005.01.005, 15840421.
30. Oquendo MA, Galfalvy H, Russo S, Ellis SP, Grunebaum MF, Burke A, Mann JJ. Prospective study of clinical predictors of suicidal acts after a major depressive episode in patients with major depressive disorder or bipolar disorder. Am J Psychiatry 2004, 161:1433-1441. 10.1176/appi.ajp.161.8.1433, 15285970.
31. Beevers CG, Miller IW. Perfectionism, cognitive bias, and hopelessness as prospective predictors of suicidal ideation. Suicide Life Threat Behav 2004, 34:126-137. 10.1521/suli.34.2.126.32791, 15191269.
32. Esposito C, Spirito A, Boergers J, Donaldson D. Affective, behavioral, and cognitive functioning in adolescents with multiple suicide attempts. Suicide Life Threat Behav 2003, 33:389-399. 10.1521/suli.33.4.389.25231, 14695054.