Allosteric effects of the antipsychotic drug trifluoperazine on the energetics of calcium binding by calmodulin

Proteins: Structure, Function and Bioinformatics

Volumn 78, Issue 10, 2010, Pages 2265-2282

  Feldkamp, Michael D ^a   O'Donnell, Susan E ^a   Yu, Liping ^a   Shea, Madeline A ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

Allostery; Binding; Linkage; NMR; Titration

Indexed keywords

CALCIUM ION; CALMODULIN; TRIFLUOPERAZINE; CALCIUM; CALMODULIN (1-80); CALMODULIN (76-148); LIGAND; NEUROLEPTIC AGENT; PEPTIDE FRAGMENT; PROTEIN BINDING; RECOMBINANT PROTEIN;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; CALCIUM BINDING; CRYSTAL STRUCTURE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; BIOLOGY; BLOOD; CALCIUM SIGNALING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; GENETICS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE; OSMOLARITY; PARAMECIUM; PROTEIN DATABASE;

ANIMALS; ANTIPSYCHOTIC AGENTS; BINDING SITES; CALCIUM; CALCIUM SIGNALING; CALMODULIN; COMPUTATIONAL BIOLOGY; DATABASES, PROTEIN; KINETICS; LIGANDS; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OSMOLAR CONCENTRATION; PARAMECIUM; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS; TRIFLUOPERAZINE;

EID: 77955788858     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22739     Document Type: Article

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