The Gln27Glu polymorphism in β2-adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis

Lipids in Health and Disease

Volumn 9, Issue , 2010, Pages

  Daghestani, Maha H ^a   Warsy, Arjumand A ^a   Daghestani, Mazin H ^b   Al Odaib, Ali N ^c   Eldali, Abdelmoneim ^c   Al Eisa, Nadia A ^a   Al Zhrani, Sabah ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b UMM AL QURA UNIVERSITY   (Saudi Arabia)

^c KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; GLUTAMIC ACID; GLUTAMINE; INSULIN; LEPTIN; TRIACYLGLYCEROL; LIPID;

ADULT; ANTHROPOMETRY; ARTICLE; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HYPERINSULINEMIA; HYPERLEPTINEMIA; HYPERTRIGLYCERIDEMIA; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; OBESITY; POLYMERASE CHAIN REACTION; SAUDI ARABIA; SEQUENCE ANALYSIS; ADOLESCENT; AMINO ACID SUBSTITUTION; BLOOD; GENETICS; HYPERINSULINISM;

ADOLESCENT; ADULT; AMINO ACID SUBSTITUTION; ANTHROPOMETRY; BODY MASS INDEX; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HUMANS; HYPERINSULINISM; HYPERTRIGLYCERIDEMIA; LEPTIN; LIPIDS; MALE; OBESITY; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; SAUDI ARABIA; YOUNG ADULT;

EID: 77955787247     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-9-90     Document Type: Article

References (21)

1. Current understanding of the etiology of obesity: Genetic and non-genetic factors. C Bouchard, Am J Clin Nutr 1991 53 1561 1565
2. The effects of beta 2 adrenergic receptor gene polymorphism in lipid profiles. Kao Wei-Tsung Yung Chieh Yen For Wey Lung, Lipids in Health and Diseases 2009 50 1 8
3. Fat cell adrenergic receptor and the control of white and brown fat cell function. M Berlan, J Lipid Res 1993 34 1057 1091 8371057
4. Lipolytic catecholamine resistance due to decreased beta 2-adrenoceptor expression in fat cells. F Lonnqvist H Wahrenberg L Hellstorm S Reynisdottir P Arner, J Clin Invest 1992 90 6 2175 2186 10.1172/JCI116103 1334970
5. 3-adrenoceptor in man. S Encksson M Shimizu F Lonnovist J Nordenstorm P Arner, J Clin Invest 1995 95 2239 2245 10.1172/JCI117914 7738189
6. Pharmacogenetics of 1- and 2-adrenergic receptors. SB Liggett, Pharmacology 2000 61 3 167 173 10.1159/000028397 10971202
7. Amino-terminal polymorphisms of the human 2-adrenergic receptor impart distinct agonist-promoted regulator properties. SA Green J Turki M Innis SB Liggett, Biochemistry 1994 33 9414 9419 10.1021/bi00198a006 7915137
8. Association of polymorphisms in the2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus. S Ishiyama-Shigemoto K Yamada X Yuan F Ichikawa K Nonaka, Diabetologia 1999 42 98 101 10.1007/s001250051120 10027586
9. Gln27Glu 2-adrenergic receptor variant is associated with hypertriglyceridemia and the development of fatty liver. N Iwamoto Y Ogawa S Kajihara A Hisatomi T Yasutake T Yoshimura T Mizuta T Hara I Ozaki K Yamamoto, Clin Chim Acta 2001 314 85 91 10.1016/S0009-8981(01)00633-7 11718682
10. Genetic variance and lipolysis regulation: implications for obesity. P Arner, Ann Med 2001 33 542 546 10.3109/07853890108995964 11730161
11. Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men. T Hayakawa Y Nagai T Kahara H Yamashita T Takamura T Abe G Nomura K Kobayashi, Metabolism 2000 49 1215 1218 10.1053/meta.2000.8622 11016907
12. Lack of association between a human beta2-adrenoceptor gene polymorphism (gln27glu) and morbid obesity. B Kortner AM Wolf D Wendt U Beisiegel D Evans, Int J Obes Relat Metab Disord 2000 23 1099 1100 10.1038/sj.ijo.0801063
13. The Gln27Glu polymorphismin the beta2-adrenergic receptor gene is not associated with morbid obesity in Austrian women. H Oberkofler H Esterbauer E Hell, Int J Obes Relat Metab Disord 2000 24 388 390 10.1038/sj.ijo.0801180 10757636
14. Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. V Large L Hellstrom S Reynisdottir F Lonnqvist P Eriksson L Lannfelt P Arner, J Clin Invest 1997 100 3005 3012 10.1172/JCI119854 9399946
15. 2-adrenoceptor gene polymorphism on obesity in males and in females. L Hellstrom V Large S Reynisdottir H Wahrenberg P Arner, J Intern Med 1999 245 253 259 10.1046/j.1365-2796.1999.0437e.x 10205587
16. 2-adrenoceptor polymorphisms relate to obesity through blunted leptin mediated sympathetic activation. K Masuo T Katsuya H Kawaguchi Y Fu H Rakugi T Ogihara ML Tuck, Am J Hypertens 2006 19 1084 1091 10.1016/j.amjhyper. 2006.02.015 17027833
17. Gln27Glu variant of Beta 2-adrenoreceptor gene affects male type fat accumulation in women. T Kunnas R Lachitioo M-J Kortelainen A Kalela ST Nikkari, Lipids in Health and Disease 2009 43 1 4
18. Association of polymorphism in the 2-adrenergic receptor gene with obesity, hypertriglyceridemia, and diabetes mellitus. S Ishiyama-Shigemoto K Yamada X Yuan K Nonaka, Diabetologia 1999 42 98 101 10.1007/s001250051120 10027586 (Pubitemid 29039745)
19. The Gln27Glu 2-adrenergic receptor variant is associated with obesity due to subcutaneous fat accumulation in Japanese men. Y Mori H Kim-Motoyama Y Ito T Katakura Kazuki Yasuda Satomi Ishiyama-Shigemoto Kentaro Yamada Yasuo Akanuma Yasuo Ohashi Satoshi Kimura Yoshio Yazaki Takashi Kadowaki, Biochem Biophys Res Commun 1999 258 138 140 10.1006/bbrc.1999.0607 10222249
20. Interaction among the 2-, 2-, and3-adrenergic receptor genes and obesity-related phenotypes in the Quebec family study. O Ukkola O Rankinen SJ Weisnage, Metabolism 2000 49 1063 1070 10.1053/meta.2000.7708 10954027
21. Significance of beta2-adrenergic receptor gene polymorphism in obesity and type 2 diabetes mellitus in Korean subjects. S Kim D Kim IA Seo M Lee K Kim M Lee, Metabolism 2002 51 833 37 10.1053/meta.2002.33347 12077726