Urinary albumin excretion is associated with pulmonary hypertension in sickle cell disease: Potential role of soluble fms-like tyrosine kinase-1

European Journal of Haematology

Volumn 85, Issue 3, 2010, Pages 257-263

  Ataga, Kenneth I ^a,b   Brittain, Julia E ^a,b   Moore, Dominic ^a   Jones, Susan K ^a,b   Hulkower, Ben ^a   Strayhorn, Dell ^a,b   Adam, Soheir ^a,b   Redding Lallinger, Rupa ^a,b   Nachman, Patrick ^b   Orringer, Eugene P ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

albuminuria; endothelial activation; pulmonary hypertension; sFLT 1; Sickle cell disease

Indexed keywords

ALBUMIN; CREATININE; HEMOGLOBIN F; LACTATE DEHYDROGENASE; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN RECEPTOR 1; FLT1 PROTEIN, HUMAN;

ADULT; ALBUMINURIA; ARTICLE; BODY MASS; COHORT ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; CREATININE BLOOD LEVEL; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DOPPLER ECHOCARDIOGRAPHY; FEMALE; HEMOLYSIS; HUMAN; INFLAMMATION; LEUKOCYTE COUNT; LUNG ARTERY PRESSURE; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MICROALBUMINURIA; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RETICULOCYTE COUNT; SICKLE CELL ANEMIA; SICKLE CELL BETA THALASSEMIA; STROKE; SYSTOLIC BLOOD PRESSURE; THROMBOCYTE COUNT; UREA NITROGEN BLOOD LEVEL; URINARY EXCRETION; AGE DISTRIBUTION; AGING; COMPLICATION; HYPERTENSION, PULMONARY; KIDNEY FUNCTION TEST; METABOLISM; URINE; YOUNG ADULT;

ADULT; AGE DISTRIBUTION; AGING; ALBUMINURIA; ANEMIA, SICKLE CELL; COHORT STUDIES; CROSS-SECTIONAL STUDIES; HEMOLYSIS; HUMANS; HYPERTENSION, PULMONARY; KIDNEY FUNCTION TESTS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; YOUNG ADULT;

EID: 77955784929     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2010.01471.x     Document Type: Article

References (38)

1. Gladwin MT, Sachdev V, Jison ML, et al. Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med 2004 350 : 886 95.
2. Ataga KI, Moore CG, Jones S, et al. Pulmonary hypertension in patients with sickle cell disease: a longitudinal study. Br J Haematol 2006 134 : 109 15.
3. Castro O, Hoque M, Brown BD. Pulmonary hypertension in sickle cell disease: cardiac catheterization results and survival. Blood 2003 101 : 1257 61.
4. De Castro LM, Jonassaint JC, Graham FL, et al. Pulmonary hypertension associated with sickle cell disease: clinical and laboratory endpoints and disease outcomes. Am J Hematol 2008 83 : 19 25.
5. Aslan M, Ryan TM, Adler B, et al. Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proc Natl Acad Sci USA 2001 98 : 15215 20.
6. Reiter CD, Wang X, Tanus-Santos JE, Hogg N, Cannon RO, Schechter AN, Gladwin MT. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med 2002 8 : 1383 9.
7. Ataga KI, Moore CG, Hillery CA, Jones S, et al. Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension. Haematologica 2008 93 : 20 6.
8. Patel N, Gonsalves CS, Malik P, Kalra VK. Placenta growth factor augments endothelin-1 and endothelin-B receptor expression via hypoxia-inducible factor-1 alpha. Blood 2008 112 : 856 65. Epub 2008 Apr 14.
9. Niu X, Nouraie M, Campbell A, et al. Angiogenic and inflammatory markers of cardiopulmonary changes in children and adolescents with sickle cell disease. PLoS ONE 2009 4 : e7956.
10. Brittain JE, Hulkower B, Jones SK, Strayhorn D, De Castro L, Telen MJ, Orringer EP, Hinderliter A, Ataga KI. Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. Blood 2009 115 : 2014 20.
11. Gordeuk VR, Campbell A, Rana S, et al. Relationship of erythropoietin, fetal hemoglobin, and hydroxyurea treatment to tricuspid regurgitation velocity in children with sickle cell disease. Blood 2009 114 : 4639 44.
12. Guasch A, Navarette J, Nass K, Zayas CF. Glomerular involvement in adults with sickle cell hemoglobinopathies: prevalence and clinical correlates of progressive renal failure. J Am Soc Nephrol 2006 17 : 2228 35.
13. McBurney PG, Hanevold CD, Hernandez CM, et al. Risk factors for microalbuminuria in children with sickle cell anemia. J Pediatr Hematol Oncol 2002 24 : 473 7.
14. McKie KT, Hanevold CD, Hernandez C, et al. Prevalence, prevention, and treatment of microalbuminuria and proteinuria in children with sickle cell disease. J Pediatr Hematol Oncol 2007 29 : 140 4.
15. National Kidney Foundation. KDOQI clinical practice guidelines for chronic kidney disease: evaluation, classification and stratification. Am J Kidney Dis 2002 39 (2 Suppl. 1 S1 266.
16. McQuillan BM, Picard MH, Leavitt M, Weyman AE. Clinical correlates and reference intervals for pulmonary artery systolic pressure among echocardiographically normal subjects. Circulation 2001 104 : 2797 802.
17. Platt OS, Brambilla DJ, Rosse WF, et al. Mortality in sickle cell disease. Life expectancy and risk factors for early death. N Engl J Med 1994 330 : 1639 44.
18. Alvarez O, Montane B, Lopez G, et al. Early blood transfusions protect against microalbuminuria in children with sickle cell disease. Pediatr Blood Cancer 2006 47 : 71 6.
19. Landburg PP, Elsenga H, Schnog JB, et al. Increased serum levels of anti-angiogenic factors like soluble fms-like tyrosine kinase and soluble endoglin in sickle cell disease. Acta Haematol 2008 120 : 130 3.
20. Ataga KI, Brittain JE, Desai P, Delaney J, Jones SK, Strayhorn D, Redding-Lallinger R, Orringer EP. Association of soluble fms-like tyrosine kinase (sFLT-1) with pulmonary hypertension and hemolysis in sickle cell disease. Annual National Sickle Cell Disease Scientific Meeting, Hollywood, Florida, February, 2010.
21. Fischer C, Mazzone M, Jonckx B, Carmeliet P. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy. Nat Rev Cancer 2008 8 : 942 56.
22. Yoshimatsu J, Matsumoto H, Goto K, et al. Relationship between urinary albumin and serum soluble fms-like tyrosine kinase 1 (sFlt-1) in normal pregnancy. Eur J of Obstet Gynecol Reprod Biol 2006 128 : 204 8.
23. Koga K, Osuga Y, Yoshino O, et al. Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia. J Clin Endocrinol Metab 2003 88 : 2348 51.
24. Tsatsaris V, Goffin F, Munaut C, et al. Overexpression of the soluble vascular endothelial growth factor in preeclamptic patients: pathophysiological consequences. J Clin Endocrinol Metab 2003 88 : 5555 63.
25. Vuorela P, Helske S, Hornig C, et al. Amniotic fluid-soluble vascular endothelial growth factor receptor-1 in preeclampsia. Obstet Gynecol 2000 95 : 353 7.
26. Kim NH, Oh JH, Seo JA, et al. Vascular endothelial growth factor (VEGF) and soluble VEGF receptor FLT-1 in diabetic nephropathy. Kidney Int 2005 67 : 167 77.
27. Ayerden EF, Haksun E, Ulver DB, et al. The relationship between vascular endothelial growth factor (VEGF) and microalbuminuria in patients with essential hypertension. Intern Med 2008 47 : 1511 6.
28. Kato GJ, Gladwin MT, Steinberg MH. Deconstructing sickle cell disease: reappraisal of the role of hemolysis in the development of clinical phenotypes. Blood Rev 2007 21 : 37 47.
29. Thompson J, Reid M, Hambleton I, Serjeant GR. Albuminuria and renal function in homozygous sickle cell disease. Arch Intern Med 2007 167 : 701 8.
30. Astor BC, Muntner P, Levin A, et al. Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med 2002 162 : 1401 8.
31. Hsu CY, McCulloch CE, Curhan GC. Epidemiology of anemia associated with chronic renal insufficiency among adults in the United States: results from the Third National Health and Nutrition Examination Survey. J Am Soc Nephrol 2002 13 : 504 10.
32. Machado RF, Anthi A, Steinberg MH, et al. N-terminal pro-brain natriuretic peptide levels and risk of death in sickle cell disease. JAMA 2006 296 : 310 8.
33. Pemberton CJ, Johnson ML, Yandle TG, et al. Deconvolution analysis of cardiac natriuretic pepides during acute volume overload. Hypertension 2000 36 : 355 9.
34. Anwaruddin S, Lliyd-Jones DM, Baggish A, et al. Renal function, congestive heart failure, and amino-terminal pro-brain natriuretic peptide measurement: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) Study. J Am Coll Cardiol 2006 47 : 91 7.
35. Powars DR, Elliot-Mills DD, Chan L, et al. Chronic renal failure in sickle cell disease: risk factors, clinical course, and mortality. Ann Intern Med 1991 115 : 614 20.
36. Foucan L, Bourhis V, Bangou J, et al. A randomized trial of captopril for microalbuminuria in normotensive adults with sickle cell anemia. Am J Med 1998 104 : 339 42.
37. Fitzhugh CD, Wigfall DR, Ware RE. Enalapril and hydroxyurea therapy for children with sickle nephropathy. Pediatr Blood Cancer 2005 45 : 982 5.
38. Fornoni A, Liaz A, Tejada T, Lenz O. Role of inflammation in diabetic nephropathy. Curr Diabetes Rev 2008 4 : 10 7.