Vaccination of mice with Porphyromonas gingivalis or Fusobacterium nucleatum modulates the inflammatory response, but fails to prevent experimental periodontitis

Journal of Clinical Periodontology

Volumn 37, Issue 9, 2010, Pages 812-817

  Polak, David ^a   Wilensky, Asaf ^a   Shapira, Lior ^a   Weiss, Ervin I ^a   Houri Haddad, Yael ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

alveolar bone loss; F. nucleatum; mixed infection; P. gingivalis; vaccination

Indexed keywords

BACTERIAL VACCINE; BACTERIUM ANTIBODY; INACTIVATED VACCINE; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ALVEOLAR BONE LOSS; ANIMAL; ARTICLE; BACTEROIDACEAE INFECTION; BAGG ALBINO MOUSE; BLOOD; COMPARATIVE STUDY; DISEASE COURSE; FEMALE; FUSOBACTERIUM INFECTION; FUSOBACTERIUM NUCLEATUM; GERMFREE ANIMAL; IMMUNIZATION; IMMUNOLOGY; MICRO-COMPUTED TOMOGRAPHY; MICROBIOLOGY; MOUSE; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; SUBCUTANEOUS DRUG ADMINISTRATION; TIME; VACCINATION;

ALVEOLAR BONE LOSS; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; BACTEROIDACEAE INFECTIONS; DISEASE PROGRESSION; FEMALE; FUSOBACTERIUM INFECTIONS; FUSOBACTERIUM NUCLEATUM; IMMUNIZATION; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-1BETA; MICE; MICE, INBRED BALB C; PERIODONTITIS; PORPHYROMONAS GINGIVALIS; SPECIFIC PATHOGEN-FREE ORGANISMS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; VACCINATION; VACCINES, INACTIVATED; X-RAY MICROTOMOGRAPHY;

EID: 77955765075     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2010.01598.x     Document Type: Article

References (20)

1. Baker, P. J., Evans, R. T. Roopenian, D. C. (1994) Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice. Archieves of Oral Biology 39, 1035 1040.
2. Bascones, A., Noronha, S., Gomez, M., Mota, P., Gonzalez Moles, M. A. Dorrego, M. V. (2005) Tissue destruction in periodontitis: bacteria or cytokines fault? Quintessence International 36, 299 306.
3. Choi, J. I., Borrello, M. A., Smith, E. S. Zauderer, M. (2000) Polarization of Porphyromonas gingivalis-specific helper T-cell subsets by prior immunization with Fusobacterium nucleatum. Oral Microbiology Immunology 15, 181 187.
4. Ebersole, J. L., Brunsvold, M., Steffensen, B., Wood, R. Holt, S. C. (1991) Effects of immunization with Porphyromonas gingivalis and Prevotella intermedia on progression of ligature-induced periodontitis in the nonhuman primate Macaca fascicularis. Infection and Immunity 59, 3351 3359.
5. Feuille, F., Ebersole, J. L., Kesavalu, L., Stepfen, M. J. Holt, S. C. (1996) Mixed infection with Porphyromonas gingivalis and Fusobacterium nucleatum in a murine lesion model: potential synergistic effects on virulence. Infection and Immunity 64, 2094 2100.
6. Gemmell, E., Bird, P. S., Ford, P. J., Ashman, R. B., Gosling, P., Hu, Y. Seymour, G. J. (2004) Modulation of the antibody response by Porphyromonas gingivalis and Fusobacterium nucleatum in a mouse model. Oral Microbiology and Immunology 19, 247 251.
7. Genco, C. A., Cutler, C. W., Kapczynski, D., Maloney, K. Arnold, R. R. (1991) A novel mouse model to study the virulence of and host response to Porphyromonas (Bacteroides) gingivalis. Infection and Immunity 59, 1255 1263.
8. Gonzalez, D., Tzianabos, A. O., Genco, C. A. Gibson, F. C. III. (2003) Immunization with Porphyromonas gingivalis capsular polysaccharide prevents P. gingivalis-elicited oral bone loss in a murine model. Infection and Immunity 71, 2283 2287.
9. Houri-Haddad, Y., Soskolne, W. A., Halabi, A., Barak, V. Shapira, L. (2000) Repeat bacterial challenge in a subcutaneous chamber model results in augmented tumour necrosis factor-alpha and interferon-gamma response, and suppression of interleukin-10. Immunology 99, 215 220.
10. Houri-Haddad, Y., Soskolne, W. A., Halabi, A. Shapira, L. (2005) The effect of immunization on the response to P. gingivalis infection in mice is adjuvant-dependent. Journal of Clinical Periodontology 32, 933 937.
11. Kesavalu, L., Sathishkumar, S., Bakthavatchalu, V., Matthews, C., Dawson, D., Steffen, M. Ebersole, J. L. (2007) Rat model of polymicrobial infection, immunity, and alveolar bone resorption in periodontal disease. Infection and Immunity 75, 1704 1712.
12. Kolenbrander, P. E. Andersen, R. N. (1989) Inhibition of coaggregation between Fusobacterium nucleatum and Porphyromonas (Bacteroides) gingivalis by lactose and related sugars. Infection and Immunity 57, 3204 3209.
13. Moritz, A. J., Cappelli, D., Lantz, M. S., Holt, S. C. Ebersole, J. L. (1998) Immunization with Porphyromonas gingivalis cysteine protease: effects on experimental gingivitis and ligature-induced periodontitis in Macaca fascicularis. Journal of Periodontology 69, 686 697.
14. Page, R. C. (2000) Vaccination and periodontitis: myth or reality. Journal of the International Academy of Periodontology 2, 31 43.
15. Persson, G. R. (2005) Immune responses and vaccination against periodontal infections. Journal of Clinical Periodontology 32 (Suppl. 6), 39 53.
16. Polak, D., Wilensky, A., Shapira, L., Halabi, A., Goldstein, D., Weiss, E. I. Houri-Haddad, Y. (2009) Mouse model of experimental periodontitis induced by Porphyromonas gingivalisFusobacterium nucleatum infection: bone loss and host response. Journal of Clinical Periodontology 36, 406 410.
17. Rajapakse, P. S., O'Brien-Simpson, N. M., Slakeski, N., Hoffmann, B. Reynolds, E. C. (2002) Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model. Infection and Immunity 70, 2480 2486.
18. Stoicov, C., Whary, M., Rogers, A. B., Lee, F. S., Klucevsek, K., Li, H., Cai, X., Saffari, R., Ge, Z., Khan, I. A., Combe, C., Luster, A., Fox, J. G. Houghton, J. (2004) Coinfection modulates inflammatory responses and clinical outcome of Helicobacter felis and Toxoplasma gondii infections. Journal of Immunology 173, 3329 3336.
19. Vitovec, J., Aldova, E., Vladik, P. Krovacek, K. (2001) Enteropathogenicity of Plesiomonas shigelloides and Aeromonas spp. in experimental mono- and coinfection with Cryptosporidium parvum in the intestine of neonatal BALBc mice. Comparitive Immunology, Microbiology and Infectious Disease 24, 39 55.
20. Wilensky, A., Gabet, Y., Yumoto, H., Houri-Haddad, Y. Shapira, L. (2005) Three-dimensional quantification of alveolar bone loss in Porphyromonas gingivalis-infected mice using micro-computed tomography. Journal of Periodontology 76, 1282 1286.