Equine grass sickness: Are we any nearer to answers on cause and prevention after a century of research?

Equine Veterinary Journal

Volumn 42, Issue 6, 2010, Pages 477-481

  Newton, J R ^a   Wylie, C E ^a   Proudman, C J ^b   McGorum, B C ^c   Poxton, I R ^d  

^a ANIMAL HEALTH TRUST   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VACCINE;

ANIMAL; ANIMAL DISEASE; ARTICLE; AUTONOMIC NEUROPATHY; BOTULISM; HORSE; HORSE DISEASE; IMMUNOLOGY; MYENTERIC PLEXUS; PATHOLOGY; RESEARCH; TIME; UNITED KINGDOM; AUTONOMIC NERVOUS SYSTEM DISEASES; COMPLICATION; EPIDEMIOLOGY; HORSE DISEASES; VETERINARY;

ANIMALS; AUTONOMIC NERVOUS SYSTEM DISEASES; BACTERIAL VACCINES; BOTULISM; GREAT BRITAIN; HORSE DISEASES; HORSES; MYENTERIC PLEXUS; RESEARCH; TIME FACTORS;

EQUIDAE;

EID: 77955758170     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2010.00155.x     Document Type: Article

References (31)

1. Araya O, Vits L, Paredes E, Ildefonso R. Grass sickness in horses in southern Chile. Vet. Rec. 2002, 150:695-697.
2. Archer D, Pinchbeck G, Proudman C, Clough H. Is equine colic seasonal? Novel application of a model based approach. BMC vet. Res. 2006, 2:27.
3. Collier DS, Collier SO, Rossdale PD. Grass sickness - the same old suspects but still no convictions! Equine vet. J. 2001, 33:540-542.
4. Doxey DL, Gilmour JS, Milne EM. A comparative study of normal equine populations and those with grass sickness (dysautonomia) in eastern Scotland. Equine vet. J. 1991, 23:365-369.
5. Forsyth AA. Grass disease in a coalmine. Vet. J. 1941, 97:26-28.
6. French NP, McCarthy HE, Diggle PJ, Proudman CJ. Clustering of equine grass sickness cases in the United Kingdom: A study considering the effect of position-dependent reporting on the space-time K-function. Epidemiol. Infect. 2005, 133:343-348.
7. Gilmour JS, Jolly GM. Some aspects of the epidemiology of equine grass sickness. Vet. Rec. 1974, 95:77-81.
8. Hedderson EJ, Newton JR. Prospects for vaccination against equine grass sickness. Equine vet. J. 2004, 36:186-191.
9. Hunter LC, Poxton IR. Systemic antibodies to Clostridium botulinum type C: Do they protect horses from grass sickness (dysautonomia)? Equine vet. J. 2001, 33:547-553.
10. Hunter LC, Miller JK, Poxton IR. The association of Clostridium botulinum type C with equine grass sickness: A toxicoinfection? Equine vet. J. 1999, 31:492-499.
11. Lannek N, Lindberg P, Persson F. A grass disease enzootic in stable-fed horses with an investigation of the aetiological role of the food. Vet. Rec. 1961, 73:601-603.
12. McCarthy HE, Proudman CJ, French NP. Epidemiology of equine grass sickness: A literature review (1909-1999). Vet. Rec. 2001, 149:293-300.
13. McCarthy HE, French NP, Edwards GB, Miller K, Proudman CJ. Why are certain premises at increased risk of equine grass sickness? A matched case-control study. Equine vet. J. 2004a, 36:130-134.
14. McCarthy HE, French NP, Edwards GB, Poxton IR, Kelly DF, Payne-Johnson CE, Miller K, Proudman CJ. Equine grass sickness is associated with low antibody levels to Clostridium botulinum: A matched case-control study. Equine vet. J. 2004b, 36:123-129.
15. Mellor DJ, Love S, Walker R, Gettinby G, Reid SW. Sentinel practice-based survey of the management and health of horses in northern Britain. Vet. Rec. 2001, 149:417-423.
16. Newton JR, Hedderson EJ, Adams VJ, McGorum BC, Proudman CJ, Wood JL. An epidemiological study of risk factors associated with the recurrence of equine grass sickness (dysautonomia) on previously affected premises. Equine vet. J. 2004, 36:105-112.
17. Nunn F, Cave TA, Knottenbelt C, Poxton IR. Association between Key-Gaskell syndrome and infection by Clostridium botulinum type C/D. Vet. Rec. 2004, 155:111-115.
18. Nunn FG, Pirie RS, McGorum B, Wernery U, Poxton IR. Comparison of IgG antibody levels to Clostridium botulinum antigens between euthanased and surviving cases of chronic grass sickness. Res. vet. Sci. 2007a, 83:82-84.
19. Nunn FG, Pirie RS, McGorum B, Wernery U, Poxton IR. Preliminary study of mucosal IgA in the equine small intestine: Specific IgA in cases of acute grass sickness and controls. Equine vet. J. 2007b, 39:457-460.
20. Poxton IR, Hunter LC, Brown R, Lough HG, Miller JK. Clostridia and equine grass sickness. Rev. Med. Microbiol. 1997, 8:S52.
21. Steinman A, Kachtan I, Levi O, Shpigel NY. Seroprevalence of antibotulinum neurotoxin type C antibodies in horses in Israel. Equine vet. J. 2007, 39:232-235.
22. Tocher JF, Brown W, Tocher JW, Buxton JB. 'Grass Sickness' Investigation Report. Vet. Rec. 1923, 3:75-89.
23. Uzal FA, Robles CA. Mal seco, a grass sickness-like syndrome of horses in Argentina. Vet. Res. Commun. 1993, 17:449-457.
24. Waggett BE, McGorum BC, Wernery U, Shaw DJ, Pirie RS. Prevalence of Clostridium perfringens in faeces and ileal contents from grass sickness affected horses: Comparisons with 3 control populations. Equine vet. J. 2010, 42:494-499.
25. Whitwell KE. Do hares suffer from grass sickness? Vet. Rec. 1991, 128:395-396.
26. Whitwell K, Needham J. Mucoid enteropathy in UK rabbits: Dysautonomia confirmed. Vet. Rec. 1996, 139:323-323.
27. Wood JL, McGorum BC, Mayhew IG. Equine dysautonomia: Has grass been blamed unfairly all this time? Equine vet. J. 1999, 31:451-452.
28. Wood JL, Milne EM, Doxey DL. A case-control study of grass sickness (equine dysautonomia) in the United Kingdom. Vet. J. 1998, 156:7-14.
29. Woods JA, Gilmour JS. A suspected case of grass sickness in the Falkland Islands. Vet. Rec. 1991, 128:359-360.
30. Wright A, Beard L, Bawa B, Bras J. Dysautonomia in a six-year-old mule in the United States. Equine vet. J. 2010, 42:170-173.
31. Wylie CE, Proudman CJ. Equine grass sickness: Epidemiology, diagnosis, and global distribution. Vet. Clin. N. Am.: Equine Pract. 2009, 25:381-399.