Pharmacokinetics of enteric-coated cysteamine bitartrate in healthy adults: A pilot study

British Journal of Clinical Pharmacology

Volumn 70, Issue 3, 2010, Pages 376-382

  Gangoiti, Jon A ^a   Fidler, Meredith ^a   Cabrera, Betty L ^a   Schneider, Jerry A ^a   Barshop, Bruce A ^a   Dohil, Ranjan ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Control subjects; Cystagon ; Cystinosis; Plasma cysteamine

Indexed keywords

GASTRIN; MERCAPTAMINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; CYSTINOSIS; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG RELEASE; DRUG TOLERABILITY; DRUG UPTAKE; ENTERIC COATED TABLET; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN EXPERIMENT; LETHARGY; MALE; NORMAL HUMAN; PALLOR; PILOT STUDY; PRIORITY JOURNAL; SINGLE DRUG DOSE; UPPER GASTROINTESTINAL TRACT; VOMITING;

ADOLESCENT; AREA UNDER CURVE; CYSTEAMINE; CYSTINOSIS; FEMALE; GASTRINS; HUMANS; INTESTINAL ABSORPTION; MALE; RADIATION-PROTECTIVE AGENTS; TABLETS, ENTERIC-COATED; YOUNG ADULT;

EID: 77955722879     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2010.03721.x     Document Type: Article

References (14)

1. Gahl WA, Thoene JG, Schneider JA. Cystinosis. N Engl J Med 2002 347 : 111 121.
2. Pisoni RL, Thoene JG, Christensen HN. Detection and characterization of carrier-mediated cationic amino acid transport in lysosomes of normal and cystinotic human fibroblasts. Role in therapeutic cystine removal? J Biol Chem 1985 260 : 4791 4798.
3. Gahl WA, Reed GF, Thoene JG, Schulman JD, Rizzo WB, Jonas AJ, Denman DW, Schlesselman JJ, Corden BJ, Schneider JA. Cysteamine therapy for children with nephropathic cystinosis. N Engl J Med 1987 316 : 971 977.
4. Markello TC, Bernardini IM, Gahl WA. Improved renal function in children with cystinosis treated with cysteamine. N Engl J Med 1993 328 : 1157 1162.
5. Levtchenko EN, van Dael CM, de Graaf-Hess AC, Wilmer MJ, van den Heuvel LP, Monnens LA, Blom HJ. Strict cysteamine dose regimen is required to prevent nocturnal cystine accumulation in cystinosis. Pediatr Nephrol 2006 21 : 110 113.
6. Kleta R, Bernardini I, Ueda M, Varade WS, Phornphutkul C, Krasnewich D, Gahl WA. Long-term follow-up of well-treated nephropathic cystinosis patients. J Pediatr 2004 145 : 555 560.
7. Wenner WJ, Murphy JL. The effects of cysteamine on the upper gastrointestinal tract of children with cystinosis. Pediatr Nephrol 1997 11 : 600 603.
8. Dohil R, Fidler M, Barshop B, Newbury R, Sellers Z, Deutsch R, Schneider J. Esomeprazole therapy for gastric acid hypersecretion in children with cystinosis. Pediatr Nephrol 2005 20 : 1786 1793.
9. Dohil R, Newbury RO, Sellers ZM, Deutsch R, Schneider JA. The evaluation and treatment of gastrointestinal disease in children with cystinosis receiving cysteamine. J Pediatr 2003 143 : 224 230.
10. Dohil R, Fidler M, Barshop BA, Gangoiti J, Deutsch R, Martin M, Schneider JA. Understanding intestinal cysteamine bitartrate absorption. J Pediatr 2006 148 : 764 769.
11. Fidler MC, Barshop BA, Gangoiti JA, Deutsch R, Martin M, Schneider JA, Dohil R. Pharmacokinetics of cysteamine bitartrate following gastrointestinal infusion. Br J Clin Pharmacol 2007 63 : 36 40.
12. Guan XHG, Dwivedi C, Matthees DP. A simultaneous liquid chromatography/mass spectrometric assay of glutathione, cysteine, homecysteine and their disulfides in biological samples. J Pharmaceut Biomed Anal 2003 31 : 251 261.
13. Gahl WA, Balog JZ, Kleta R. Nephropathic cystinosis in adults: natural history and effects of oral cysteamine therapy. Ann Intern Med 2007 147 : 242 250.
14. Smolin LA, Schneider JA. Measurement of total plasma cysteamine using high-performance liquid chromatography with electrochemical detection. Anal Biochem 1988 168 : 374 379.