Peripheral acid-sensing ion channels and P2X receptors contribute to mechanical allodynia in a rodent thrombus-induced ischemic pain model

Journal of Pain

Volumn 11, Issue 8, 2010, Pages 718-727

  Seo, Hyoung Sig ^a   Roh, Dae Hyun ^b   Yoon, Seo Yeon ^a   Kang, Suk Yun ^a   Moon, Ji Young ^a   Kim, Hyun Woo ^c   Han, Ho Jae ^b   Chung, Jin Mo ^d   Beitz, Alvin J ^e   Lee, Jang Hern ^a  

^a Seoul National University   (South Korea)

^b Chonnam National University   (South Korea)

^c Chungnam National University   (South Korea)

^d University of Texas Medical Branch School of Medicine   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

acid sensing ion channel; mechanical allodynia; P2X receptor; Peripheral ischemia; tissue acidosis

Indexed keywords

ACID SENSING ION CHANNEL; AMILORIDE; CHELERYTHRINE; EGTAZIC ACID; FERRIC CHLORIDE; N (1,4 BENZODIOXAN 6 YL) 3 (4 TERT BUTYLPHENYL)ACRYLAMIDE; PURINERGIC P2X RECEPTOR; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; VANILLOID RECEPTOR 1; NERVE PROTEIN; PURINERGIC P2 RECEPTOR; SODIUM CHANNEL; TRPV1 PROTEIN, RAT; VANILLOID RECEPTOR;

ACIDOSIS; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; HEAT; HYPERALGESIA; LIMB ISCHEMIA; MODEL; NOCICEPTION; NONHUMAN; PAIN; PERIPHERAL OCCLUSIVE ARTERY DISEASE; RAT; SIGNAL TRANSDUCTION; THROMBOSIS; ANALYSIS OF VARIANCE; ANIMAL; COMPLICATION; ISCHEMIA; MALE; METABOLISM; SPRAGUE DAWLEY RAT;

ANALYSIS OF VARIANCE; ANIMALS; HOT TEMPERATURE; HYPERALGESIA; ISCHEMIA; MALE; NERVE TISSUE PROTEINS; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; SODIUM CHANNELS; TRPV CATION CHANNELS; ACID SENSING ION CHANNELS; RECEPTORS, PURINERGIC P2X;

EID: 77955714674     PISSN: 15265900     EISSN: 15288447     Source Type: Journal    
DOI: 10.1016/j.jpain.2009.10.010     Document Type: Article

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