Prevalence and significance of anti-prothrombin (aPT) antibodies in patients with Lupus Anticoagulant (LA)

Thrombosis Research

Volumn 126, Issue 2, 2010, Pages 150-153

  Pengo, V ^a   Denas, G ^a   Bison, E ^a   Banzato, A ^a   Padayattil Jose, S ^a   Gresele, P ^b   Marongiu, F ^c   Erba, N ^d   Veschi, F ^d   Ghirarduzzi, A ^e   De Candia, E ^f   Montaruli, B ^g   Marietta, M ^h   Testa, S ^d   Barcellona, D ^c   Tripodi, A ⁱ  

^a UNIVERSITY HOSPITAL OF PADOVA   (Italy)

^b University Hospital   (Italy)

^c DEPARTMENT OF RADIOLOGY   (Italy)

^d District Hospital   (Italy)

^e District Hospital   (Italy)

^f FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

^g District Hospital   (Italy)

^h District Hospital   (Italy)

ⁱ FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

Author keywords

2Glycoprotein I; antibodies; Lupus Anticoagulant; prothrombin; thrombosis

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS ANTICOAGULANT; PROTHROMBIN ANTIBODY;

ANTIPHOSPHOLIPID SYNDROME; ARTICLE; BLOOD; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; LABORATORY; MAJOR CLINICAL STUDY; MALE; PREVALENCE; PRIORITY JOURNAL; THROMBOEMBOLISM; THROMBOSIS;

ADULT; ANTIBODIES; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; FEMALE; HUMANS; LUPUS COAGULATION INHIBITOR; MALE; MIDDLE AGED; PROTHROMBIN;

EID: 77955711302     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2010.05.018     Document Type: Article

References (25)

1. R.A. Roubey Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other "antiphospholipid" autoantibodies Blood 84 1994 2854 2867
2. D.A. Horbach, E. van Oort, R.C. Donders, R.H. Derksen, and P.G. de Groot Lupus anticoagulant is the strongest risk factor for both venous and arterial thrombosis in patients with systemic lupus erythematosus. Comparison between different assays for the detection of antiphospholipid antibodies Thromb Haemost 76 1996 916 924
3. M. Galli, D. Luciani, G. Bertolini, and T. Barbui Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature Blood 101 2003 1827 1832
4. S. Miyakis, M.D. Lockshin, T. Atsumi, D.W. Branch, R.L. Brey, and R. Cervera International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) J Thromb Haemost 4 2006 295 306
5. V. Pengo, A. Biasiolo, P. Rampazzo, and T. Brocco dRVVT is more sensitive than KCT or TTI for detecting lupus anticoagulant activity of anti-beta2-glycoprotein I autoantibodies Thromb Haemost 81 1999 256 258
6. V. Pengo, G. Balestrieri, A. Tincani, L. Spatola, A. Biasiolo, and T. Brocco Utilization of dilute Russell's viper venom time to detect autoantibodies against beta 2-glycoprotein I which express anticoagulant activity in the presence but not in the absence of exogenous phospholipids Thromb Haemost 77 1997 123 126
7. M.J. Simmelink, D.A. Horbach, R.H. Derksen, J.C. Meijers, E.M. Bevers, and G.M. Willems Complexes of anti-prothrombin antibodies and prothrombin cause lupus anticoagulant activity by competing with the binding of clotting factors for catalytic phospholipid surfaces Br J Haematol 113 2001 621 629
8. B. de Laat, R.H. Derksen, R.T. Urbanus, and P.G. de Groot IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis Blood 105 2005 1540 1545
9. M. Galli, D. Luciani, G. Bertolini, and T. Barbui Anti-beta 2-glycoprotein I, antiprothrombin antibodies, and the risk of thrombosis in the antiphospholipid syndrome Blood 102 2003 2717 2723
10. R. Forastiero, M. Martinuzzo, G. Pombo, D. Puente, A. Rossi, and L. Celebrin A prospective study of antibodies to beta2-glycoprotein I and prothrombin, and risk of thrombosis J Thromb Haemost 3 2005 1231 1238
11. N. Bizzaro, A. Ghirardello, S. Zampieri, L. Iaccarino, R. Tozzoli, and A. Ruffatti Anti-prothrombin antibodies predict thrombosis in patients with systemic lupus erythematosus: a 15-year longitudinal study J Thromb Haemost 5 2007 1158 1164
12. V. Pengo, A. Biasiolo, P. Gresele, F. Marongiu, N. Erba, and F. Veschi Survey of lupus anticoagulant diagnosis by central evaluation of positive plasma samples J Thromb Haemost 5 2007 925 930
13. J.T. Brandt, D.A. Triplett, B. Alving, and I. Scharrer Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH Thromb Haemost 74 1995 1185 1190
14. V. Pengo, A. Biasiolo, T. Brocco, S. Tonetto, and A. Ruffatti Autoantibodies to phospholipid binding plasma proteins in patients with thrombosis and phospholipid-reactive antibodies Thromb Haemost 75 1996 721 724
15. J.P. Miletich, G.J. Broze Jr., and P.W. Majerus The synthesis of sulfated dextran beads for isolation of human plasma coagulation factors II, IX, and X Anal Biochem 105 1980 304 310
16. V. Pengo, A. Biasiolo, and M.G. Fior Autoimmune antiphospholipid antibodies are directed against a cryptic epitope expressed when beta 2-glycoprotein I is bound to a suitable surface Thromb Haemost 73 1995 29 34
17. A. Tincani, F. Allegri, G. Balestrieri, G. Reber, M. Sanmarco, and P. Meroni Minimal requirements for antiphospholipid antibodies ELISAs proposed by the European Forum on antiphospholipid antibodies Thromb Res 114 2004 553 558
18. G. Reber, A. Tincani, M. Sanmarco, P. de Moerloose, and M.C. Boffa Proposals for the measurement of anti-beta2-glycoprotein I antibodies. Standardization group of the European Forum on Antiphospholipid Antibodies J Thromb Haemost 2 2004 1860 1862
19. B. de Laat, P.G. de Groot, R.H. Derksen, R.T. Urbanus, K. Mertens, and F.R. Rosendaal Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men Blood 114 2009 3656 3661
20. M.L. Bertolaccini, T. Atsumi, M.A. Khamashta, O. Amengual, and G.R. Hughes Autoantibodies to human prothrombin and clinical manifestations in 207 patients with systemic lupus erythematosus J Rheumatol 25 1998 1104 1108
21. O. Vaarala, M. Puurunen, M. Manttari, V. Manninen, K. Aho, and T. Palosuo Antibodies to prothrombin imply a risk of myocardial infarction in middle-aged men Thromb Haemost 75 1996 456 459
22. M. Puurunen, O. Vaarala, H. Julkunen, K. Aho, and T. Palosuo Antibodies to phospholipid-binding plasma proteins and occurrence of thrombosis in patients with systemic lupus erythematosus Clin Immunol Immunopathol 80 1996 16 22
23. A. Ghirardello, N. Bizzaro, S. Zampieri, L. Iaccarino, N. Bassi, and R. Tozzoli Biological and Clinical Relevance of Anti-Prothrombin Antibodies Ann NY Acad Sci 1109 2007 503 510
24. V. Pengo, A. Biasiolo, T. Brocco, S. Tonetto, and A. Ruffatti Autoantibodies to phospholipid binding plasma proteins in patients with thrombosis and phospholipid-reactive antibodies Thromb Haemost 75 1996 721 724
25. J. Swadzba, L.S. De Clerck, W.J. Stevens, C.H. Bridts, K.A. van Cotthem, and J. Musial Anticardiolipin, anti-beta(2)-glycoprotein I, antiprothrombin antibodies, and lupus anticoagulant in patients with systemic lupus erythematosus with a history of thrombosis J Rheumatol 24 1997 1710 1715