Complexes of anti-prothrombin antibodies and prothrombin cause lupus anticoagulant activity by competing with the binding of clotting factors for catalytic phospholipid surfaces

British Journal of Haematology

Volumn 113, Issue 3, 2001, Pages 621-629

  Simmelink, Marleen J A ^a,b   Horbach, Daniëlle A ^a,b   Derksen, Ronald H W M ^a   Meijers, Joost C M ^a,b,e   Bevers, Edouard M ^c,d   Willems, George M ^d   De Groot, Philip G ^a,b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Anti phospholipid antibodies; Lupus anticoagulants; Phospholipids; Prothrombinase activity; Tenase activity

Indexed keywords

BLOOD CLOTTING FACTOR; BLOOD CLOTTING FACTOR 10A; LUPUS ANTICOAGULANT; PHOSPHOLIPID; PHOSPHOLIPID ANTIBODY; PROTHROMBIN;

ANTIBODY AFFINITY; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BLOOD CLOTTING; CATALYSIS; ENZYME ACTIVITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; THROMBOGENESIS; THROMBOSIS;

ANTIPHOSPHOLIPID SYNDROME; AUTOANTIBODIES; CYSTEINE ENDOPEPTIDASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FACTOR XA; FEMALE; HUMANS; LIPID BILAYERS; LUPUS COAGULATION INHIBITOR; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; NEOPLASM PROTEINS; PHOSPHOLIPIDS; PROTEIN BINDING; PROTHROMBIN; THROMBOPLASTIN;

EID: 0034993220     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02755.x     Document Type: Article

References (32)

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