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Volumn 24, Issue 8, 2010, Pages 1523-1525

Identification of a secondary FLT3/A848P mutation in a patient with FLT3-ITD-positive blast phase CMML and response to sunitinib and sorafenib

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CD135 ANTIGEN; CYTARABINE; DOXORUBICIN; HYDROXYUREA; PROLINE; SORAFENIB; SUNITINIB;

EID: 77955710421     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.122     Document Type: Letter
Times cited : (16)

References (10)
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    • Stone RM, DeAngelo DJ, Klimek V, Galinsky I, Estey E, Nimer SD et al. Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood 2005; 105: 54-60.
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  • 3
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    • A phase 2 trial of the FLT3 inhibitor lestaurtinib (CEP701) as first-line treatment for older patients with acute myeloid leukemia not considered fit for intensive chemotherapy
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  • 4
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    • A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML)or not amenable to conventional therapy for the disease
    • Fiedler W, Serve H, Dohner H, Schwittay M, Ottmann OG, O0Farrell AM et al. A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia (AML)or not amenable to conventional therapy for the disease. Blood 2005; 105: 986-993.
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  • 6
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  • 7
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    • Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain
    • Heidel F, Solem FK, Breitenbuecher F, Lipka DB, Kasper S, Thiede MH et al. Clinical resistance to the kinase inhibitor PKC412 in acute myeloid leukemia by mutation of Asn-676 in the FLT3 tyrosine kinase domain. Blood 2006; 107: 293-300.
    • (2006) Blood , vol.107 , pp. 293-300
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  • 9
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.