Synthesis, characterization, mechanism of decomposition, and antiproliferative activity of a class of PEGylated benzopolysulfanes structurally similar to the natural product varacin

Journal of Organic Chemistry

Volumn 75, Issue 16, 2010, Pages 5549-5557

  Mahendran, Adaickapillai ^a   Vuong, Angela ^a   Aebisher, David ^a   Gong, Yaqiong ^b   Bittman, Robert ^b   Arthur, Gilbert ^c   Kawamura, Akira ^d   Greer, Alexander ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b CITY UNIVERSITY OF NEW YORK   (United States)

^c UNIVERSITY OF MANITOBA   (Canada)

^d CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE BOND; ANTI-TUMOR ACTIVITIES; ANTIPROLIFERATIVE ACTIVITIES; CELL KILLING; DRUG LEADS; ETHANETHIOL; HUMAN TUMOR CELLS; HYDROXIDE IONS; INTRINSIC SOLUBILITIES; KEY PARAMETERS; LOW CONCENTRATIONS; MECHANISM OF DECOMPOSITION; NATURAL PRODUCTS; NORBORNENES; PENTATHIEPIN; RING STRUCTURES; T-CELL LEUKEMIA; TRANSFER REACTION; WATER SOLUBILITIES;

AMIDES; CELL CULTURE; ORGANIC POLYMERS; SYNTHESIS (CHEMICAL);

SOLUBILITY;

6 (2 AMINOETHYL)BENZOPENTATHIEPIN; AMIDE; ANTINEOPLASTIC AGENT; HYDROXIDE; LISSOCLINOTOXIN A; N [2 [2 (2 METHOXYETHOXY)ETHOXY]ETHYL]BENZO[D][1,2,3]TRITHIOLE 5 CARBOXAMIDE; N [2 [2 (2 METHOXYETHOXY)ETHOXY]ETHYL]BENZO[E][1,2,3,4]TETRATHIINE 6 CARBOXAMIDE; N [2 [2 (2 METHOXYETHOXY)ETHOXY]ETHYL]BENZO[F][1,2,3,4,5]PENTATHIEPINE 7 CARBOXAMIDE; N [2 [2 (2 METHOXYETHOXY)ETHOXY]ETHYL]BENZO[G][1,2,3,4,5,6]HEXATHIOCINE 8 CARBOXAMIDE; N [2 [2 (2 METHOXYETHOXY)ETHOXY]ETHYL]BENZO[H][1,2,3,4,5,6,7]HEPTATHIONINE 9 CARBOXAMIDE; N [2 [2 (2 METHOXYETHOXY)ETHOXY]ETHYL]BENZO[J][1,2,3,4,5,6,7,8,9]NONATHIACYCLOUNDECINE 11 CARBOXAMIDE; N,N DIMETHYL 5 (METHYLTHIO)VARACIN; NATURAL PRODUCT; PARENT BENZOPENTASULFANE; PEGYLATED BENZOPOLYSULFANE DERIVATIVE; UNCLASSIFIED DRUG; VARACIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL KILLING; CELL PROLIFERATION; CHEMICAL REACTION; CONTROLLED STUDY; DECOMPOSITION; DESULFURIZATION; DRUG MECHANISM; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; LEUKEMIA CELL LINE; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; SOLUBILIZATION;

ANTINEOPLASTIC AGENTS; BIOLOGICAL FACTORS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ETHYLAMINES; HUMANS; MOLECULAR STRUCTURE; POLYETHYLENE GLYCOLS; SULFIDES; SULFUR COMPOUNDS;

EID: 77955699305     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo100870q     Document Type: Article

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