IFN gamma gene polymorphism may contribute to the susceptibility to CLL

Pathology and Oncology Research

Volumn 16, Issue 2, 2010, Pages 213-216

  Urbanowicz, Iwona ^a   Mazur, Grzegorz ^a   Stacherzak Pawlik, Jolanta ^a   Bogunia Kubik, Katarzyna ^b   Wróbel, Tomasz ^a   Wozniak, Mieczyslaw ^a   Kuliczkowski, Kazimierz ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

Author keywords

Chronic lymphocytic leukemia; Gene polymorphism; INF gamma

Indexed keywords

CHLORAMBUCIL; CYCLOPHOSPHAMIDE; DNA; DOXORUBICIN; GAMMA INTERFERON; PREDNISOLONE; VINCRISTINE;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; CANCER STAGING; CANCER SUSCEPTIBILITY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; POLYMERASE CHAIN REACTION;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERFERON-GAMMA; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL;

EID: 77955691116     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-009-9209-2     Document Type: Article

References (16)

1. Abbott BL (2004) Advances in the diagnosis and treatment of chronic lymphocytic leukemia. Clin Adv Hematol Oncol 2:448-454
2. Zenz T, Mertens D, Dohner H, Stilgenbauer S (2008) Molecular diagnostics in chronic lymphocytic leukemia-Pathogenetic and clinical implications. Leuk Lymphoma 15:1-10
3. Mainou-Fowler T, Prentice AG (1996) Modulation of apoptosis with cytokines in B-cell chronic lymphocytic leukemia. Leuk Lymphoma 21:369-377
4. Pravica V, Perrey C, Stevens A et al (2000) A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production. Hum Immunol 61:863-866
5. Pravica V, Asderakis A, Perrey C et al (1999) In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene. Eur J Immunogenet 26:1-3
6. Perrey C, Pravica V, Sinnott PJ, Hutchinson IV (1998) Genotyping for polymorphisms in interferon-gamma, interleukin-10, transforming growth factor-beta 1 and tumour necrosis factoralpha genes: a technical report. Transpl Immunol 6:193-197
7. Bogunia-Kubik K,Mazur G, Urbanowicz I,Wróbel T, Kuliczkowski K, Wozniak M, Lange A (2006) Lack of association between the TNF-alpha promoter gene polymorphism and susceptibility to B-cell chronic lymphocytic leukemia. Int J Immunogenet 33:21-24
8. Kiaii S, Choudhury A, Mozaffari F, Rezvany R, Lundin J, Mellstedt H, Osterborg A (2006) Signaling molecules and cytokine production in T cells of patients with B-cell chronic lymphocytic leukemia: long-term effects of fludarabine and alemtuzumab treatment. Leuk Lymphoma 47:1229-1238
9. Kiaii S, Choudhury A, Mozaffari F, Kimby E, Osterborg A, Mellstedt H (2005) Signaling molecules and cytokine production in T cells of patients with B-cell chronic lymphocytic leukemia (B-CLL): comparison of indolent and progressive disease. Med Oncol 22:291-302
10. Rossmann ED, Lewin N, Jeddi-Tehrani M, Osterborg A, Mellstedt H (2002) Intracellular T cell cytokines in patients with B cell chronic lymphocytic leukaemia (B-CLL). Eur J Haematol 68:299-306
11. Podhorecka M, Dmoszynska A, Rolinski J (2004) Intracellular IFN-gamma expression by CD3+/CD8+ cell subset in B-CLL patients correlates with stage of the disease. Eur J Haematol 73:29-35
12. Totero D, Tazzari PL, Capaia M, Montera MP, Clavio M, Balleari E, Foa R, Gobbi M (2003) CD40 triggering enhances fludarabineinduced apoptosis of chronic lymphocytic leukemia B-cells through autocrine release of tumor necrosis factor-alpha and interferon-gama and tumor necrosis factor receptor-I-II upregulation. Haematologica 88:148-158
13. Gallego A, Vargas JA, Castejón R, Citores MJ, Romero Y, Millán I, Durántez A (2003) Production of intracellular IL-2, TNF-alpha, and IFN-gamma by T cells in B-CLL. Cytometry B Clin Cytom 56:23-29
14. Warle MC, Farhan A, Metselaar HJ et al (2003) Are cytokine gene polymorphisms related to in vitro cytokine production profiles? Liver Transpl 9:170-181
15. Vandenbroeck K, Goris A (2003) Cytokine gene polymorphisms in multifactorial diseases: gateways to novel targets for immunotherapy? Trends Pharmacol Sci 24:284-289
16. Zaki M, Douglas R, Patten N, Bachinsky M, Lamb R, Nowell P, Moore J (2000) Disruption of the IFN-gamma cytokine network in chronic lymphocytic leukemia contributes to resistance of leukemic B cells to apoptosis. Leuk Res 24:611-621