A theoretical method to improve and optimize the design of bioartificial livers

Biotechnology and Bioengineering

Volumn 106, Issue 6, 2010, Pages 980-988

  Davidson, Adam J ^a   Ellis, Marianne J ^a   Chaudhuri, Julian B ^a  

^a University of Bath   (United Kingdom)

Author keywords

Bioartificial liver; Hollow fibers; Mathematical model

Indexed keywords

BIOARTIFICIAL LIVER; CELL POPULATIONS; CLINICAL TRIAL; DESIGN ISSUES; DESIGN RANGE; DIFFUSION LIMITED; HEPATOCYTES; HOLLOW FIBER; HOLLOW FIBER BIOREACTOR; KROGH CYLINDER; LIVER FAILURE; MASS TRANSPORT; MATHEMATICAL MODELING; MODELING RESULTS; OPERATING CONSTRAINTS; OPERATING PARAMETERS; OPERATING REGIONS; THIN-WALLED;

BIOLOGICAL MATERIALS PRESERVATION; CELL CULTURE; CELL PROLIFERATION; DESIGN; FIBERS; LIVER; MASS TRANSFER; MULTIVARIABLE CONTROL SYSTEMS; OXYGEN;

MATHEMATICAL MODELS;

OXYGEN;

ARTICLE; BIOARTIFICIAL LIVER; BLOOD FLOW VELOCITY; CELL COUNT; CELL POPULATION; DEVICE; HOLLOW FIBER REACTOR; LIVER CELL; LIVER FUNCTION; MATHEMATICAL MODEL; OXYGEN TRANSPORT; PROCESS DESIGN; PROCESS OPTIMIZATION; THEORETICAL MODEL; ARTIFICIAL LIVER; BIOREACTOR; HUMAN; METABOLISM;

BIOREACTORS; HEPATOCYTES; HUMANS; LIVER, ARTIFICIAL; MODELS, THEORETICAL; OXYGEN;

EID: 77955674788     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22765     Document Type: Article

References (30)

1. Brotherton JD, Chau PC. 1996. Modeling of axial-flow hollow fiber cell culture bioreactors. Biotechnol Prog 12(5):575-590.
2. De Groot H, Littauer A, Noll T. 1988. Metabolic and pathological aspects of hypoxia in liver cells. In: Acker H, editor. Oxygen sensing in tissue. New York: Springer-Verlag. p. 49-64.
3. de Rave S, Tilanus HW, van der Linden J, de Man RA, van der Berg B, Hop WCJ, Ijzermans JNM, Zondervan PE, Metselaar HJ. 2002. The importance of orthotopic liver transplantation in acute hepatic failure. Transpl Int 15(1):29-33. (Pubitemid 36055896)
4. Demetriou AA, Brown RS, Busuttil RW, Fair J, McGuire BM, Rosenthal P, Esch JSA, Lerut J, Nyberg SL, Salizzoni M, Fagan EA, de Hemptinne B, Broelsch CE, Muraca M, Salmeron JM, Rabkin JM, Metselaar HJ, Pratt D, De La Mata M, McChesney LP, Everson GT, Lavin PT, Stevens AC, Pitkin Z, Solomon BA. 2003. Prospective, randomized, multicenter, controlled trial of a bioartificial liver in treating acute liver failure; 2003 Nov 30-Dec 03. Hot Springs, VA: Lippincott Williams & Wilkins. p. 660-667.
5. Diekmann S, Bader A, Schmitmeier S. 2006. Present and future developments in hepatic tissue engineering for liver support systems - State of the art and future developments of hepatic cell culture techniques for the use in liver support systems. Cytotechnology 50(1-3):163-179. (Pubitemid 44243939)
6. Gerlach JC, Zedinger K, Patzer JF. 2008. Bioartificial liver systems: Why, what, whither? Regener Med 3(4):575-595.
7. Hay PD, Veitch AR, Smith MD, Cousins RB, Gaylor JDS. 2000. Oxygen transfer in a diffusion-limited hollow fiber bioartificial liver. Artif Organs 24(4):278-288.
8. Hay PD, Veitch AR, Gaylor JDS. 2001. Oxygen transfer in a convection-enhanced hollow fiber bioartificial liver. Artif Organs 25(2):119-130.
9. Krogh A. 1919. The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. J Physiol 52(6):409-415.
10. Kundu PK, Cohen IM. 2001. Fluid mechanics. Boston, Mass; London: Academic Press. xxiv, 730. pp.
11. McCuskey RS. 2008. The hepatic microvascular system in health and its response to toxicants. Anat Rec 291(6):661-671.
12. McKenzie TJ, Lillegard JB, Nyberg SL. 2008. Artificial and bioartificial liver support. Semin Liver Dis 28(2):210-217.
13. Nyberg SL, Remmel RP, Mann HJ, Peshwa MV, Hu WS, Cerra FB. 1994. Primary hepatocytes outperform Hep G2 cells as the source of biotransformation functions in a bioartificial liver. Ann Surg 220(1):59-67.
14. Peszynski P, Peters E, Schmidt R. 2001. Albumin dialysis: Single pass vs. recirculation (MARS); 2001 Sep 07-09. Rostock, Germany: Blackwell Munksgaard. p. 40-42.
15. Piret JM, Cooney CL. 1990. Mammalian-cell and protein distributions in ultrafiltration hollow fiber bioreactors. Biotechnol Bioeng 36(9):902-910.
16. Piret JM, Cooney CL. 1991. Model of oxygen-transport limitations in hollow fiber bioreactors. Biotechnol Bioeng 37(1):80-92.
17. Pless G, Sauer IM. 2005. Bioartificial liver: Current status. Transplant Proc 37(9):3893-3895.
18. Rozga J, Williams F, Ro MS, Neuzil DF, Giorgio TD, Backfisch G, Moscioni AD, Hakim R, Demetriou AA. 1993. Development of a Bioartificial Liver - Properties and function of a hollow-fiber module inoculated with liver-cells. Hepatology 17(2):258-265. (Pubitemid 23046698)
19. Sander R. 2007. Compilation of Henry's law constants for inorganic and organic species of potential importance in environmental chemistry (Version 3). Mainz: Max Planck Institute for Chemistry.
20. Sauer IM, Kardassis D, Zeillinger K, Pascher A, Gruenwald A, Pless G, Irgang M, Kraemer M, Puhl G, Frank J, et al. 2003. Clinical extracorporeal hybrid liver support - phase I study with primary porcine liver cells. Xenotransplantation 10(5):460-469. (Pubitemid 37129891)
21. Stange J, Mitzner SR, Risler T, Erley CM, Lauchart W, Goehl H, Klammt S, Peszynski P, Freytag J, Hickstein H, et al. 1999. Molecular adsorbent recycling system (MARS): Clinical results of a new membrane-based blood purification system for bioartificial liver support. Artif Organs 23(4):319-330. (Pubitemid 29200993)
22. Strain AJ, Neuberger JM. 2002. A bioartificial liver - State of the art. Science 295(5557):1005.
23. Sullivan JP, Gordon JE, Bou-Akl T, Matthew HWT, Palmer AF. 2007. Enhanced oxygen delivery to primary hepatocytes within a hollow fiber bioreactor facilitated via hemoglobin-based oxygen carriers. Artif Cells Blood Subst Biotechnol 35(6):585-5606.
24. Tilles AW, Baskaran H, Roy P, Yarmush ML, Toner M. 2001. Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat-plate bioreactor. Biotechnol Bioeng 73(5):379-389. (Pubitemid 32493234)
25. van de Kerkhove MP, Hoekstra R, Chamuleau RAFM, van Gulik TM. 2004. Clinical application of bioartificial liver support systems. Ann Surg 240(2):216-230. (Pubitemid 38963011)
26. Wigg AJ, Padbury RT. 2005. Liver support systems: Promise and reality. J Gastroenterol Hepatol 20(12):1807-1816. (Pubitemid 43961034)
27. Willaert R, Smets A, De Vuyst L. 1999. Mass transfer limitations in diffusion-limited isotropic hollow fiber bioreactors. Biotechnol Tech 13(5):317-323. (Pubitemid 29294299)
28. Woodley JM, Titchener-Hooker NJ. 1996. The use of windows of operation as a bioprocess design tool. Bioprocess Eng 14(5):263-268. (Pubitemid 126450708)
29. Ye H, Das DB, Triffitt JT, Cui ZF. 2006. Modelling nutrient transport in hollow fibre membrane bioreactors for growing three-dimensional bone tissue. J Membr Sci 272(1-2):169-178. (Pubitemid 43176625)
30. Zhou YH, Titchener-Hooker NJ. 1999. Visualizing integrated bioprocess designs through "windows of operation". Biotechnol Bioeng 65(5):550-557.