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Volumn 14, Issue 4, 2010, Pages 337-349

Best practices in the management of toxicities related to anti-EGFR agents for metastatic colorectal cancer

Author keywords

Anti EGFR agents; Cetuximab; Colorectal cancer; Dermatologic; Diarrhoea; Hypomagnesaemia; Infusion reactions; Ocular; Panitumumab; Toxicities

Indexed keywords


EID: 77955664258     PISSN: 14623889     EISSN: 15322122     Source Type: Journal    
DOI: 10.1016/j.ejon.2010.03.004     Document Type: Article
Times cited : (38)

References (72)
  • 3
    • 34547591852 scopus 로고    scopus 로고
    • Ocular toxicities of epidermal growth factor receptor inhibitors and their management
    • Basti S. Ocular toxicities of epidermal growth factor receptor inhibitors and their management. Cancer Nursing 2007, 30:S10-S16.
    • (2007) Cancer Nursing , vol.30
    • Basti, S.1
  • 4
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • Benvenuti S., Sartore-Bianchi A., Di Nicolantonio F., Zanon C., Moroni M., Veronese S., Siena S., Bardelli A. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Research 2007, 67:2643-2648.
    • (2007) Cancer Research , vol.67 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Zanon, C.4    Moroni, M.5    Veronese, S.6    Siena, S.7    Bardelli, A.8
  • 5
    • 36949039745 scopus 로고    scopus 로고
    • Predictive value of skin toxicity severity for response to panitumumab in patients with metastatic colorectal cancer (mCRC): a pooled analysis of five clinical trials
    • (abstr 4134)
    • Berlin J., Van Cutsem E., Peeters M., Hecht J.R., Ruiz R., Wolf M., Amado R.G., Meropol N.J. Predictive value of skin toxicity severity for response to panitumumab in patients with metastatic colorectal cancer (mCRC): a pooled analysis of five clinical trials. Journal of Clinical Oncology 2007, 25:18s. (abstr 4134).
    • (2007) Journal of Clinical Oncology , vol.25
    • Berlin, J.1    Van Cutsem, E.2    Peeters, M.3    Hecht, J.R.4    Ruiz, R.5    Wolf, M.6    Amado, R.G.7    Meropol, N.J.8
  • 6
    • 77955663704 scopus 로고    scopus 로고
    • August 17-21, EGFR-Inhibitors induced skin reactions. Presented at the International Society of Nurses in Cancer Care Conference, Singapore, China.
    • Boers-Doets, C., Ouwerkerk, J., August 17-21, 2008. EGFR-Inhibitors induced skin reactions. Presented at the International Society of Nurses in Cancer Care Conference, Singapore, China.
    • (2008)
    • Boers-Doets, C.1    Ouwerkerk, J.2
  • 8
    • 38549142436 scopus 로고    scopus 로고
    • Impact and management of skin toxicity associated with anti-epidermal growth factor receptor therapy: survey results
    • Boone S.L., Rademaker A., Liu D., Pfeiffer C., Mauro D.J., Lacouture M.E. Impact and management of skin toxicity associated with anti-epidermal growth factor receptor therapy: survey results. Oncology 2007, 72:152-159.
    • (2007) Oncology , vol.72 , pp. 152-159
    • Boone, S.L.1    Rademaker, A.2    Liu, D.3    Pfeiffer, C.4    Mauro, D.J.5    Lacouture, M.E.6
  • 11
    • 34249732333 scopus 로고    scopus 로고
    • Hypomagnesemia in patients with stage IV colorectal cancer treated with cetuximab as a single agent
    • (abstr 3655)
    • Carson E.J., Novak A.M., Stella P.J. Hypomagnesemia in patients with stage IV colorectal cancer treated with cetuximab as a single agent. Journal of Clinical Oncology 2005, 23(Suppl. 16s). (abstr 3655).
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.SUPPL. 16S
    • Carson, E.J.1    Novak, A.M.2    Stella, P.J.3
  • 15
    • 28244440281 scopus 로고    scopus 로고
    • Managing cutaneous side effects of epidermal growth factor receptor (HER2/EGFR) inhibitors
    • Dick S.E., Crawford G.H. Managing cutaneous side effects of epidermal growth factor receptor (HER2/EGFR) inhibitors. Community Oncology 2005, 2:492-496.
    • (2005) Community Oncology , vol.2 , pp. 492-496
    • Dick, S.E.1    Crawford, G.H.2
  • 18
    • 33750199017 scopus 로고    scopus 로고
    • Ocular toxicity related to cetuximab monotherapy in patients with colorectal cancer
    • Dranko S., Kinney C., Ramanathan R.K. Ocular toxicity related to cetuximab monotherapy in patients with colorectal cancer. Clinical Colorectal Cancer 2006, 6:224-225.
    • (2006) Clinical Colorectal Cancer , vol.6 , pp. 224-225
    • Dranko, S.1    Kinney, C.2    Ramanathan, R.K.3
  • 20
    • 69249232886 scopus 로고    scopus 로고
    • Available from:, Bristol-Meyers Squbb, Branchburg, NJ, (accessed 9 July 2009)
    • Erbitux (Cetuximab) Prescribing Information 2008, Available from:, Bristol-Meyers Squbb, Branchburg, NJ, (accessed 9 July 2009). http://packageinserts.bms.com/pi/pi_erbitux.pdf.
    • (2008) Erbitux (Cetuximab) Prescribing Information
  • 21
    • 33748675101 scopus 로고    scopus 로고
    • Merck KGaA, Darmstadt, Germany, Available from:(accessed 11 November 2008)
    • Erbitux (Cetuximab) Summary of Product Characteristics 2009, Merck KGaA, Darmstadt, Germany, Available from:(accessed 11 November 2008). http://www.emea.europa.eu/humandocs/PDFs/EPAR/erbitux/H-558-PI-en.pdf.
    • (2009) Erbitux (Cetuximab) Summary of Product Characteristics
  • 22
    • 33749034712 scopus 로고    scopus 로고
    • Cetuximab-induced hypomagnesaemia in patients with colorectal cancer
    • Fakih M.G., Wilding G., Lombardo J. Cetuximab-induced hypomagnesaemia in patients with colorectal cancer. Clinical Colorectal Cancer 2006, 6:152-156.
    • (2006) Clinical Colorectal Cancer , vol.6 , pp. 152-156
    • Fakih, M.G.1    Wilding, G.2    Lombardo, J.3
  • 23
    • 48249086178 scopus 로고    scopus 로고
    • Persisting corneal erosion under cetuximab (Erbitux) treatment (epidermal growth factor receptor antibody)
    • Foerster C.G., Cursiefen C., Kruse F.E. Persisting corneal erosion under cetuximab (Erbitux) treatment (epidermal growth factor receptor antibody). Cornea 2008, 27:612-614.
    • (2008) Cornea , vol.27 , pp. 612-614
    • Foerster, C.G.1    Cursiefen, C.2    Kruse, F.E.3
  • 24
    • 33847643669 scopus 로고    scopus 로고
    • Classification and management of skin, hair, nail, and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors
    • Galimont-Collen A.F.S., Vos L.E., Lavrijsen A.P.M., Ouwerkerk J., Gelderblom H. Classification and management of skin, hair, nail, and mucosal side-effects of epidermal growth factor receptor (EGFR) inhibitors. European Journal of Cancer 2007, 43:845-851.
    • (2007) European Journal of Cancer , vol.43 , pp. 845-851
    • Galimont-Collen, A.F.S.1    Vos, L.E.2    Lavrijsen, A.P.M.3    Ouwerkerk, J.4    Gelderblom, H.5
  • 26
    • 34047219240 scopus 로고    scopus 로고
    • Recognizing and managing toxicities of molecular targeted therapies for colorectal cancer
    • Grothey A. Recognizing and managing toxicities of molecular targeted therapies for colorectal cancer. Oncology (Williston Park) 2006, 20:21-28.
    • (2006) Oncology (Williston Park) , vol.20 , pp. 21-28
    • Grothey, A.1
  • 27
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A., Sargent D., Goldberg R.M., Schmoll H.J. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. Journal of Clinical Oncology 2004, 22:1209-1214.
    • (2004) Journal of Clinical Oncology , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3    Schmoll, H.J.4
  • 28
    • 77955664965 scopus 로고    scopus 로고
    • Panitumumab (pmab) efficacy in patients (pts) with metastatic colorectal cancer (mCRC) with low or undetectable levels of epidermal growth factor receptor (EGFr): final efficacy and KRAS analyses. In: Presented at the 2008 American Society of Clinical Oncology Gastrointestinal Cancers Symposium, January
    • Hecht, J., Mitchell, E.P., Baranda, J., Richards, D., Reiner, M., Stout, S., Amado, R.G., 2008. Panitumumab (pmab) efficacy in patients (pts) with metastatic colorectal cancer (mCRC) with low or undetectable levels of epidermal growth factor receptor (EGFr): final efficacy and KRAS analyses. In: Presented at the 2008 American Society of Clinical Oncology Gastrointestinal Cancers Symposium, January 25-27, 2008; Orlando, FL (abstract 343).
    • (2008)
    • Hecht, J.1    Mitchell, E.P.2    Baranda, J.3    Richards, D.4    Reiner, M.5    Stout, S.6    Amado, R.G.7
  • 30
    • 50249101750 scopus 로고    scopus 로고
    • Tetracycline to prevent epidermal growth factor receptor inhibitor-induced skin rashes: results of a placebo-controlled trial from the North Central Cancer Treatment Group (N03CB)
    • Jatoi A., Rowland K., Sloan J.A., Gross H.M., Fishkin P.A., Kahanic S.P., Novotny P.J., Schaefer P.L., Johnson D.B., Tschetter L.K., Loprinzi C.L. Tetracycline to prevent epidermal growth factor receptor inhibitor-induced skin rashes: results of a placebo-controlled trial from the North Central Cancer Treatment Group (N03CB). Cancer 2008, 113:847-853.
    • (2008) Cancer , vol.113 , pp. 847-853
    • Jatoi, A.1    Rowland, K.2    Sloan, J.A.3    Gross, H.M.4    Fishkin, P.A.5    Kahanic, S.P.6    Novotny, P.J.7    Schaefer, P.L.8    Johnson, D.B.9    Tschetter, L.K.10    Loprinzi, C.L.11
  • 31
    • 47149084688 scopus 로고    scopus 로고
    • Epidermal growth factor receptor monoclonal antibodies for the treatment of metastatic colorectal cancer
    • Jean G.W., Shah S.R. Epidermal growth factor receptor monoclonal antibodies for the treatment of metastatic colorectal cancer. Pharmacotherapy 2008, 28:742-754.
    • (2008) Pharmacotherapy , vol.28 , pp. 742-754
    • Jean, G.W.1    Shah, S.R.2
  • 33
    • 35648954031 scopus 로고    scopus 로고
    • Infusion-related and hypersensitivity reactions of monoclonal antibodies use to treat colorectal cancer-identification, prevention, and treatment
    • Kang S.P., Saif M.W. Infusion-related and hypersensitivity reactions of monoclonal antibodies use to treat colorectal cancer-identification, prevention, and treatment. The Journal of Supportive Oncology 2007, 5:451-457.
    • (2007) The Journal of Supportive Oncology , vol.5 , pp. 451-457
    • Kang, S.P.1    Saif, M.W.2
  • 35
    • 77955657545 scopus 로고    scopus 로고
    • Impact of pre-emptive skin toxicity (ST) treatment (tx) on panitumumab (pmab)-related skin toxicities and quality of life (QOL) in patients (pts) with metastatic colorectal cancer (mCRC): results from STEPP. Presented at the American Society of Clinical Oncology Gastrointestinal Cancers
    • Lacouture, M.E. Mitchell, E.P., Shearer, H., Iannotti, N., Piperdi, B., Pillai, M.V., Xu, F., Yassine, M., 2009. Impact of pre-emptive skin toxicity (ST) treatment (tx) on panitumumab (pmab)-related skin toxicities and quality of life (QOL) in patients (pts) with metastatic colorectal cancer (mCRC): results from STEPP. Presented at the American Society of Clinical Oncology Gastrointestinal Cancers Symposium, January 15-17, 2009; San Francisco, CA (abstract 291).
    • (2009)
    • Lacouture, M.E.1    Mitchell, E.P.2    Shearer, H.3    Iannotti, N.4    Piperdi, B.5    Pillai, M.V.6    Xu, F.7    Yassine, M.8
  • 36
    • 34547586714 scopus 로고    scopus 로고
    • Insights into the pathophysiology and management of dermatologic toxicities to EGFR-targeted therapies in colorectal cancer
    • Lacouture M.E. Insights into the pathophysiology and management of dermatologic toxicities to EGFR-targeted therapies in colorectal cancer. Cancer Nursing 2007, 30:S17-S25.
    • (2007) Cancer Nursing , vol.30
    • Lacouture, M.E.1
  • 37
    • 33646810076 scopus 로고    scopus 로고
    • The SERIES clinic: an interdisciplinary approach to the management of toxicities of EGFR inhibitors
    • Lacouture M.E., Basti S., Patel J., Benson A. The SERIES clinic: an interdisciplinary approach to the management of toxicities of EGFR inhibitors. The Journal of Supportive Oncology 2006, 4:236-238.
    • (2006) The Journal of Supportive Oncology , vol.4 , pp. 236-238
    • Lacouture, M.E.1    Basti, S.2    Patel, J.3    Benson, A.4
  • 38
    • 37049032136 scopus 로고    scopus 로고
    • First-line use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer
    • Lee J.J., Chu E. First-line use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer. Clinical Colorectal Cancer 2007, 6:S42-S46.
    • (2007) Clinical Colorectal Cancer , vol.6
    • Lee, J.J.1    Chu, E.2
  • 39
    • 77955652992 scopus 로고    scopus 로고
    • Personalised cancer therapy: what is KRAS and what does it mean for patients with metastatic colorectal cancer? EONS Newsletter. Fall
    • Lemmens, L., 2008. Personalised cancer therapy: what is KRAS and what does it mean for patients with metastatic colorectal cancer? EONS Newsletter. Fall, 28-31.
    • (2008) , pp. 28-31
    • Lemmens, L.1
  • 42
    • 35548969264 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: an evolving paradigm in clinical management
    • Lynch T.J., Kim E.S., Eaby B., Garey J., West D.P., Lacouture M.E. Epidermal growth factor receptor inhibitor-associated cutaneous toxicities: an evolving paradigm in clinical management. Oncologist 2007, 12:610-621.
    • (2007) Oncologist , vol.12 , pp. 610-621
    • Lynch, T.J.1    Kim, E.S.2    Eaby, B.3    Garey, J.4    West, D.P.5    Lacouture, M.E.6
  • 43
    • 65749101493 scopus 로고    scopus 로고
    • Management of skin rash during EGFR-targeted monoclonal antibody treatment for gastrointestinal malignancies: Canadian recommendations
    • Melosky B., Burkes R., Rayson D., Alcindor T., Shear N., Lacouture M. Management of skin rash during EGFR-targeted monoclonal antibody treatment for gastrointestinal malignancies: Canadian recommendations. Current Oncology 2009, 16:16-26.
    • (2009) Current Oncology , vol.16 , pp. 16-26
    • Melosky, B.1    Burkes, R.2    Rayson, D.3    Alcindor, T.4    Shear, N.5    Lacouture, M.6
  • 44
    • 12344312699 scopus 로고    scopus 로고
    • National Cancer Institute, Available from:(accessed November 15, 2009)
    • Common Toxicity Criteria for Adverse Events (CTCAE) Version 4.0 2009, National Cancer Institute, Available from:(accessed November 15, 2009). http://ctep.cancer.gov/protocoldevelopment/electronic_applications/docs/ctcaev4.pdf.
    • (2009) Common Toxicity Criteria for Adverse Events (CTCAE) Version 4.0
  • 45
    • 38849178281 scopus 로고    scopus 로고
    • Clinical approaches to minimize rash associated with EGFR inhibitors
    • Oishi K. Clinical approaches to minimize rash associated with EGFR inhibitors. Oncology Nursing Forum 2008, 35:103-111.
    • (2008) Oncology Nursing Forum , vol.35 , pp. 103-111
    • Oishi, K.1
  • 46
    • 55249110754 scopus 로고    scopus 로고
    • Phase III study (20050181) of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): pooled safety results
    • (abstr 4064)
    • Peeters M., Wilson G., Ducreux M., Cervantes A., André T., Hotko Y., Lordick F., Collins S., Shing M., Price T.J. Phase III study (20050181) of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): pooled safety results. Journal of Clinical Oncology 2008, 26(Suppl. 15s). (abstr 4064).
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.SUPPL. 15S
    • Peeters, M.1    Wilson, G.2    Ducreux, M.3    Cervantes, A.4    André, T.5    Hotko, Y.6    Lordick, F.7    Collins, S.8    Shing, M.9    Price, T.J.10
  • 48
    • 24644513947 scopus 로고    scopus 로고
    • Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?
    • Peréz-Soler R., Saltz L. Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?. Journal of Clinical Oncology 2005, 23:5235-5246.
    • (2005) Journal of Clinical Oncology , vol.23 , pp. 5235-5246
    • Peréz-Soler, R.1    Saltz, L.2
  • 49
    • 45549086789 scopus 로고    scopus 로고
    • Targeting metastatic colorectal cancer in 2008: a long way from 5-FU
    • Pohl A., Zhang W., Ning Y., Manegold P.C., Lurje G., Lenz H.-J. Targeting metastatic colorectal cancer in 2008: a long way from 5-FU. Oncology 2008, 22:456-462.
    • (2008) Oncology , vol.22 , pp. 456-462
    • Pohl, A.1    Zhang, W.2    Ning, Y.3    Manegold, P.C.4    Lurje, G.5    Lenz, H.-J.6
  • 50
    • 4544368057 scopus 로고    scopus 로고
    • Understanding and managing chemotherapy-induced diarrhea
    • Saltz L.B. Understanding and managing chemotherapy-induced diarrhea. The Journal of Supportive Oncology 2003, 1:35-46.
    • (2003) The Journal of Supportive Oncology , vol.1 , pp. 35-46
    • Saltz, L.B.1
  • 53
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz L.B., Meropol N.J., Loehrer P.J., Needle M.N., Kopit J., Mayer R.J. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J. Clin. Oncol 2004, 22:1201-1208.
    • (2004) J. Clin. Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer, P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 57
    • 70349939382 scopus 로고    scopus 로고
    • Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
    • Siena S., Sartore-Bianchi A., Di Nicolantonio F., Balfour J., Bardelli A. Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. Journal of National Cancer Institute 2009, 101:1308-1324.
    • (2009) Journal of National Cancer Institute , vol.101 , pp. 1308-1324
    • Siena, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3    Balfour, J.4    Bardelli, A.5
  • 58
    • 57149101253 scopus 로고    scopus 로고
    • Phase III study (PRIME/20050203) of panitumumab (pmab) with FOLFOX compared with FOLFOX alone in patients (pts) with previously untreated metastatic colorectal cancer (mCRC): pooled safety data
    • (abstr 4034)
    • Siena S., Tabernero J., Burkes R.L., Cassidy J., Cunningham D., Barugel M.E., Humblet Y., McPhie C., Shing M., Douillard J. Phase III study (PRIME/20050203) of panitumumab (pmab) with FOLFOX compared with FOLFOX alone in patients (pts) with previously untreated metastatic colorectal cancer (mCRC): pooled safety data. Journal of Clinical Oncology 2008, 26(Suppl. 15s). (abstr 4034).
    • (2008) Journal of Clinical Oncology , vol.26 , Issue.SUPPL. 15S
    • Siena, S.1    Tabernero, J.2    Burkes, R.L.3    Cassidy, J.4    Cunningham, D.5    Barugel, M.E.6    Humblet, Y.7    McPhie, C.8    Shing, M.9    Douillard, J.10
  • 59
    • 33645785843 scopus 로고    scopus 로고
    • Common side effects of anti-EGFR therapy: acneform rash
    • Sipples R. Common side effects of anti-EGFR therapy: acneform rash. Seminars in Oncology Nursing 2006, 22:28-34.
    • (2006) Seminars in Oncology Nursing , vol.22 , pp. 28-34
    • Sipples, R.1
  • 66
    • 65549089387 scopus 로고    scopus 로고
    • Available from:, Amgen, Inc., Thousand Oaks, CA, (accessed 9 July 2009)
    • Vectibix (Panitumumab) Prescribing Information 2008, Available from:, Amgen, Inc., Thousand Oaks, CA, (accessed 9 July 2009). http://www.vectibix.com/pdfs/misc/vectibix_pi.pdf.
    • (2008) Vectibix (Panitumumab) Prescribing Information
  • 67
    • 77952118055 scopus 로고    scopus 로고
    • Available from:, Amgen Europe BV, Breda, The Netherlands, (accessed 11 November 2008)
    • Vectibix (Panitumumab) Summary of Product Characteristics 2009, Available from:, Amgen Europe BV, Breda, The Netherlands, (accessed 11 November 2008). http://www.emea.europa.eu/humandocs/PDFs/EPAR/vectibix/H-741-PI-en.pdf.
    • (2009) Vectibix (Panitumumab) Summary of Product Characteristics
  • 68
    • 33751085911 scopus 로고    scopus 로고
    • Nursing care of patients receiving chemotherapy for metastatic colorectal cancer: implications of the treatment continuum concept
    • Viale P.H., Sommers R. Nursing care of patients receiving chemotherapy for metastatic colorectal cancer: implications of the treatment continuum concept. Seminars in Oncology Nursing 2007, 23:22-35.
    • (2007) Seminars in Oncology Nursing , vol.23 , pp. 22-35
    • Viale, P.H.1    Sommers, R.2
  • 69
    • 45349097237 scopus 로고    scopus 로고
    • Panitumumab: human monoclonal antibody against epidermal growth factor receptors for the treatment of metastatic colorectal cancer
    • Wu M., Rivkin A., Pham T. Panitumumab: human monoclonal antibody against epidermal growth factor receptors for the treatment of metastatic colorectal cancer. Clinical Therapeutics 2008, 30:14-30.
    • (2008) Clinical Therapeutics , vol.30 , pp. 14-30
    • Wu, M.1    Rivkin, A.2    Pham, T.3
  • 70
    • 34547668744 scopus 로고    scopus 로고
    • Acquired trichomegaly and symptomatic external ocular changes in patients receiving epidermal growth factor receptor inhibitors: case reports and a review of the literature
    • Zhang G., Basti S., Jampol L.M. Acquired trichomegaly and symptomatic external ocular changes in patients receiving epidermal growth factor receptor inhibitors: case reports and a review of the literature. Cornea 2007, 26:858-860.
    • (2007) Cornea , vol.26 , pp. 858-860
    • Zhang, G.1    Basti, S.2    Jampol, L.M.3
  • 71
    • 33847124958 scopus 로고    scopus 로고
    • Novel approaches to treatment of advanced colorectal cancer with anti-EGFR monoclonal antibodies
    • Zhang W., Gordon M., Lenz H.J. Novel approaches to treatment of advanced colorectal cancer with anti-EGFR monoclonal antibodies. Annals of Medicine 2006, 38:545-551.
    • (2006) Annals of Medicine , vol.38 , pp. 545-551
    • Zhang, W.1    Gordon, M.2    Lenz, H.J.3
  • 72
    • 42449147858 scopus 로고    scopus 로고
    • Systemic therapy for metastatic colorectal cancer: current questions
    • Zuckerman D.S., Clark J.W. Systemic therapy for metastatic colorectal cancer: current questions. Cancer 2008, 112:1879-1891.
    • (2008) Cancer , vol.112 , pp. 1879-1891
    • Zuckerman, D.S.1    Clark, J.W.2


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