Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5104-5107

  Ghosh, Arun K ^a   Dawson, Zachary L ^a   Moon, Deuk Kyu ^a   Bai, Ruoli ^b   Hamel, Ernest ^b  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Actin filament; Antitumor activity; Jasplakinolide; Natural product; Synthesis

Indexed keywords

ACTIN; AMIDE; CYCLOAMIDE; CYTOSKELETON PROTEIN; JASPAMIDE; LACTAM DERIVATIVE; MACROLACTAM DERIVATIVE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CLAISEN REARRANGEMENT; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STEREOCHEMISTRY;

CELL LINE, TUMOR; DEPSIPEPTIDES; DRUG EVALUATION, PRECLINICAL; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; STEREOISOMERISM;

EID: 77955662665     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.023     Document Type: Article

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40. 3) δ 8.61 (d, 1H), 7.99 (s, 1H), 7.53 (d, 1H), 7.17-7.08 (m, 6H), 6.84 (d, 2H), 6.60 (m, 1H), 5.91 (m, 1H), 5.29 (m, 1H), 4.93 (d, 1H), 4.71 (d, 1H), 4.62 (m, 1H), 3.77 (s, 3H), 3.33 (dd, 1H), 3.21 (dd, 1H), 2.96 (s, 3H), 2.47 (m, 2H), 2.31-2.21 (m, 2H), 1.89 (m, 1H), 1.57 (s, 3H), 1.30 (m, 1H), 1.10 (d, 3H), 0.83 (d, 3H), 0.78 (d, 3H), 0.75 (d, 3H).