Maternal lipopolysaccharide-induced inflammation during pregnancy programs impaired offspring innate immune responses

American Journal of Obstetrics and Gynecology

Volumn 203, Issue 2, 2010, Pages 185.e1-185.e4

  Beloosesky, Ron ^a   Maravi, Nir ^a   Weiner, Zeev ^a   Khatib, Nizar ^a   Awad, Nibal ^a   Boles, Julie ^b   Ross, Michael G ^b   Itskovitz Eldor, Joseph ^a  

^a RAMBAM MEDICAL CENTER   (Israel)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

innate immune response; lipopolysaccharide; neonate

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; FEMALE; IMMUNOCOMPETENCE; INFLAMMATION; INNATE IMMUNITY; NEWBORN; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROGENY; PROTEIN BLOOD LEVEL; PUP (RODENT); RAT;

EID: 77955656365     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ajog.2010.04.033     Document Type: Article

References (21)

1. J.L. Wynn, P.O. Scumpia, R.D. Winfield, et al. Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists Blood 112 2008 1750 1758
2. D.J. Barker, and C. Osmond Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales Lancet 1 1986 1077 1081
3. O.A. Kensara, S.A. Wootton, D.I. Phillips, M. Patel, A.A. Jackson, and M. Elia Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen Am J Clin Nutr 82 2005 980 987
4. C. Osmond, D.J. Barker, P.D. Winter, C.H. Fall, and S.J. Simmonds Early growth and death from cardiovascular disease in women BMJ 307 1993 1519 1524
5. M.H. Vickers, B.H. Breier, W.S. Cutfield, P.L. Hofman, and P.D. Gluckman Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition Am J Physiol Endocrinol Metab 279 2000 E83 E87
6. A.J. Drake, B.R. Walker, and J.R. Seckl Intergenerational consequences of fetal programming by in utero exposure to glucocorticoids in rats Am J Physiol Regul Integr Comp Physiol 288 2005 R34 R38
7. R. Beloosesky, D.A. Gayle, and M.G. Ross Maternal N-acetylcysteine suppresses fetal inflammatory cytokine responses to maternal lipopolysaccharide Am J Obstet Gynecol 195 2006 1053 1057 (Pubitemid 44415674)
8. O. Levy Innate immunity of the human newborn: distinct cytokine responses to LPS and other Toll-like receptor agonists J Endotoxin Res 11 2005 113 116
9. D.A. Gayle, R. Beloosesky, M. Desai, F. Amidi, S.E. Nunez, and M.G. Ross Maternal LPS induces cytokines in the amniotic fluid and corticotropin releasing hormone in the fetal rat brain Am J Physiol Regul Integr Comp Physiol 286 2004 R1024 R1029
10. R. Medzhitov, and C. Janeway Jr Innate immunity N Engl J Med 343 2000 338 344
11. R. Beloosesky, D.A. Gayle, F. Amidi, et al. N-acetyl-cysteine suppresses amniotic fluid and placenta inflammatory cytokine responses to lipopolysaccharide in rats Am J Obstet Gynecol 194 2006 268 273
12. O. Levy Innate immunity of the newborn: basic mechanisms and clinical correlates Nat Rev Immunol 7 2007 379 390
13. C. Feterowski, A. Novotny, S. Kaiser-Moore, et al. Attenuated pathogenesis of polymicrobial peritonitis in mice after TLR2 agonist pre-treatment involves ST2 up-regulation Int Immunol 17 2005 1035 1046
14. H. Weighardt, C. Feterowski, M. Veit, M. Rump, H. Wagner, and B. Holzmann Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response J Immunol 165 2000 4537 4543
15. W. Langhans Signals generating anorexia during acute illness Proc Nutr Soc 66 2007 321 330
16. M. Desai, D.A. Gayle, E. Casillas, J. Boles, and M.G. Ross Early undernutrition attenuates the inflammatory response in adult rat offspring J Matern Fetal Neonatal Med 22 2009 571 575
17. M.K. Pincus-Knackstedt, R.A. Joachim, S.M. Blois, et al. Prenatal stress enhances susceptibility of murine adult offspring toward airway inflammation J Immunol 177 2006 8484 8492
18. E. Llorente, M.L. Brito, P. Machado, and M.C. Gonzalez Effect of prenatal stress on the hormonal response to acute and chronic stress and on immune parameters in the offspring J Physiol Biochem 58 2002 143 149
19. J.E. Lawn, S. Cousens, and J. Zupan 4 Million neonatal deaths: when? where? why? Lancet 365 2005 891 900
20. P. Barton, A.C. Kalil, S. Nadel, et al. Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis Pediatrics 113 2004 7 17
21. G.S. Martin, D.M. Mannino, S. Eaton, and M. Moss The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 348 2003 1546 1554