Wound healing and protease inhibition activity of bacoside-A, isolated from Bacopa monnieri Wettest

Phytotherapy Research

Volumn 24, Issue 8, 2010, Pages 1217-1222

  Sharath, R ^a,b,d   Harish, B G ^a,c   Krishna, V ^a   Sathyanarayana, B N ^d   Kumara Swamy, H M ^a  

^a KUVEMPU UNIVERSITY   (India)

^b M S RAMAIAH INSTITUTE OF TECHNOLOGY   (India)

^c SDM College   (India)

^d UNIVERSITY OF AGRICULTURAL SCIENCES   (India)

Author keywords

Bacopa monnieri; Bacoside A; Protease inhibition; Wound healing; Zymogram assay

Indexed keywords

BACOPA MONNIERI EXTRACT; BACOSIDE A; COLLAGEN FIBER; MATRIX METALLOPROTEINASE; METHANOL; NITROFURAL; UNCLASSIFIED DRUG; MATRIX METALLOPROTEINASE INHIBITOR; PLANT EXTRACT; SAPONIN; TRITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; ENZYME INHIBITION; EPITHELIZATION; FEMALE; GRANULOMA; MALE; NONHUMAN; RAT; RAT STRAIN; SKIN INJURY; TENSILE STRENGTH; WOUND CONTRACTION; WOUND HEALING; ANIMAL; BACOPA; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECTS; INTRADERMAL DRUG ADMINISTRATION; MEDICINAL PLANT; ORAL DRUG ADMINISTRATION; PATHOLOGY;

BACOPA; BACOPA MONNIERI; RATTUS; SCROPHULARIACEAE;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ANIMALS; BACOPA; GRANULOMA; MATRIX METALLOPROTEINASE INHIBITORS; NITROFURAZONE; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; SAPONINS; TRITERPENES; WOUND HEALING;

EID: 77955651032     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3115     Document Type: Article

References (22)

1. Chillara S, Chirravuri VR, Trimurtulu G, Vanisree M, Gottumukkala V, Subbaraju. 2005. Triterpenoid glycosides from Bacopa monnieri. Phytochem 66: 2719-2728.
2. Dar A, Channa S. 1997. Relaxant effect of ethanol extract of Bacopa monnieri on rachea pulmanory artery and aorta from rabbit and guinea pig. Phytother 11: 323-325. (Pubitemid 27250270)
3. Ehrlich HP, Hunt TK. 1968. The effect of cortisone and anabolic steroids on the tensiles strength of healing wounds. Ann of Surg 57: 117-121.
4. Elangovan V, Govindaswamy S, Ramamoorthy N, Balasubramanian K. 1995. In vitro studies on the anticancer activity of Bacopa monnieri. Fitoterapia 66: 211-215.
5. Ghosh MN. 1984. Fundamentals of experimental pharmacology. Scientific Book Agency: Kolkata, India.
6. Ghosh T, Maity TK, Bose A, Dash GK, Das M. 2007. Antimicrobial activity of various fractions of ethanol extract of Bacopa monnieri Linn. aerial parts. Ind J Pharmacolo Sci 69(2): 312-314. (Pubitemid 47026126)
7. Harborne JB. 1984. Phytochemical Methods. 2nd edn. Chapman and Hall: London; 55, 84 and 120.
8. Khadeer Ahamed BM, Krishna V, Harish BG, Raja Naika H, Kumara Swamy HM, Sharath R, Chethan JD, Mahadevan KM. 2007 Isolation of bactericidal constituents from the stem bark extract of Grewia tiliaefolia Vahl. Res J Med Plant 1(3): 72-82.
9. Kokate CK, Purohit AP, Gokhale SB. 1996. Pharmacognosy. 4th edn. Nirali Prakashan: Pune; 123.
10. Kumara Swamy HM, Krishna V, Shankarmurthy K, Abdul Rahiman B, Mankani KL, Mahadevan KM. 2007. Wound healing activity of embelin isolated from the ethanol extract of leaves of Embelia ribes Burm. J Ethnopharma 109(3): 529-534. (Pubitemid 46054387)
11. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
12. Lee KH, Tong TG. 1968. Study on the Mechanism of action of salycylates, retardation of wound healing by aspirin. J Pharma Sci 57(6): 1042-1045.
13. Madden JW, Peacock EE. 1968. Studies on the biology of collagen during wound healing. Surgery 64: 288-294.
14. Martis G, Rao A. 1992. Neuropharmacological activity of Herpestis monnieri. Fitoterapia 63: 399-404.
15. Morton JJP, Malone MH. 1972. Evaluation of vulnerary activity by an open wound procedure in rats. Architect. International J Pharmacol Ther 196-117.
16. Satake M, Murata Y, Suzuki T. 1963. Studies on snake venoms XIII. Chromatographic separation and properties of three proteinases from Agkistrodon halys blomhoffii. Ven J Biochem 53: 438-447.
17. Scortichini M, Pia Rossi M. 1991. Preliminary in vitro evaluation of the antimicrobial activity of terpenes and terpenoids towards Erwinia amylovora (Burrill). J App Bacteriolo 71: 109-112.
18. Sharath Rajashekharappa, Krishna V, Sathyanarayana BN, Harish BG. 2008. Antibacterial activity of Bacoside-A an active constituent of Bacopa monnieri (L.) Wettest. Pharmacologyonline 2(2): 517-528.
19. Singh SDJ, Krishna V, Mankani KL, Manjunath BK, Vidya SM, Manohara YN. 2005. Wound healing activity of the leaf extracts and deoxyelephantopin isolated from Elephantopus scaber Linn. Ind J Pharmacol 4: 238-242. (Pubitemid 41168905)
20. Sugama J, Sanada H, Nakatani T, Nagakawa T, Inagaki M. 2005. Pressure-induced ischemic wound healing with bacterial inoculationin the rat. Wounds 17: 157-168. (Pubitemid 41159477)
21. Tripathi YB, Chaurasia S, Tripathi E, Upadyay A, Dubey GP. 1996. Bacopa monniera Linn. as an antioxidant: mechanism of action. Ind J Exp Bio 34: 523-526. (Pubitemid 26312689)
22. Zanetti VC, Da Silveria RB, Dreyfuss JL, Haoach J, Mangili OC, Veiga SS, Gremski W. 2002. Morphological and biochemical evidence of blood vessel damage and fibrinogenolysis triggered by brown spider venom. Blood Coagulation. Fibrinolysis 13: 135-148. (Pubitemid 35001677)