Three diterpenes from Leonurus japonicus Houtt protect primary cultured rat cortical cells from glutamate-induced toxicity

Phytotherapy Research

Volumn 24, Issue 8, 2010, Pages 1256-1259

  Moon, Hyung In ^a,b  

^a Dongguk University   (South Korea)

^b Wonkwang University Hospital   (South Korea)

Author keywords

Cytoprotective; Glutamate induced toxicity; Iso preleoheterin; Leojaponin; Leonurus japonicus; Prehispanolone

Indexed keywords

DITERPENE; GLUTAMIC ACID; ISOPRELEOHETERIN; LEOJAPONIN; LEONURUS JAPONICUS EXTRACT; PLANT EXTRACT; PREHISPANOLONE; UNCLASSIFIED DRUG; 13-EPI-PRELEOHETERIN;

ANIMAL CELL; ARTICLE; BRAIN CELL; BRAIN CORTEX; CELL VIABILITY; CONTROLLED STUDY; DRUG ISOLATION; FETUS; FRACTIONATION; LEONURUS; LEONURUS JAPONICUS; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RAT; SPRAGUE DAWLEY RAT; ANIMAL; CELL CULTURE; CELL PROTECTION; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ISOLATION AND PURIFICATION; TOXICITY;

LEONURUS JAPONICUS; RATTUS;

ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; CYTOPROTECTION; DITERPENES; GLUTAMIC ACID; LEONURUS; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 77955648351     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3144     Document Type: Article

References (20)

1. Buzogany K, Cucu V. 1983. Studi comparativ intre speciile Leonurus cardiaca L. si Leonurus quinquelobatus Gilib. II. Continutul in iridoide. Cluju Med LVI: 385-388.
2. Cacabelos R, Takeda M, Winblad B. 1999. The glutamatergic system and neurodegeneration in dementia: preventive strategies in Alzheimer's disease. Int J Geriatr Psychiatry 14: 3-47. (Pubitemid 29046036)
3. Calis I, Ersoz T, Tasdemir D, Ruedi P. 1992. Two phenylpropanoid glycosides from Leonurus glaucescens. Phytochemistry 31: 357-359.
4. Chinwala MG, Gao M, Dai J, Shao J. 2002. In vitro anticancer activities of Leonurus heterophyllus Sweet (Chinese motherwort herb). J Chin Med Mat 25: 71-72.
5. Choi DW, Koh JY. 1987. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase. J Neurosci Methods 20: 83-90.
6. De Souza C, Haas AP, Von Poser GL, Schapoval EE, Elisabetsky E. 2004. Ethnoparmacological studies of antimicrobial remedies in the south of Brazil. J Ethnopharmacol 90: 135-143. (Pubitemid 38091698)
7. Fraunfelder FW. 2005. Ocular side effects associated with dietary supplements and herbal medicines. Drugs Today (Barc) 41: 537-545. (Pubitemid 41503808)
8. Hotta K, Noguchi Y, Matsunaga M et al. 2003. Leonurus heterophyllus extracts and b-sitosterone as antiarrhythmics. Jpn Kokai Tokkyo Koho, 8 pp. CODEN: JKXXAF JP 2003113107 A2 20030418.
9. Kinoshita K, Tanaka J, Kuroda K, Koyama K, Natori S, Kinoshita T. 1991. Cycloleonurinin, a cyclic peptide from Leonuri Fructus. Chem Pharm Bull 39: 712-715.
10. Koo KA, Lee MK, Kim SH et al. 2007. Pinusolide and 15-methoxy-pinusolidic acid attenuate the neurotoxic effect of staurosporine in primary cultures of rat cortical cells. Br J Pharmacol 150: 65-71.
11. Koo KA, Sung SH, Kim YC. 2002. A new neuroprotective pinusolide derivative from the leaves of Biota orientalis. Chem Pharm Bull (Tokyo) 50: 834-836.
12. Lee CM, Jiang LM, Shang HS, Hon PM, He Y, Wong HN. 1991. Prehispanolone, a novel platelet-activating factor receptor antagonist from Leonurus heterophyllus. Br J Pharmacol 103: 1719-1724.
13. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63. (Pubitemid 14203433)
14. Romero-Gonzlez RR, Jorge L, Avila-Nunez JL, Aubert L, Miguel E, Alonso-Amelot ME. 2006. Labdane diterpenes from Leonurus japonicus leaves. Phytochemistry 67: 965-970. (Pubitemid 43766864)
15. Sucher NJ, Awobuluyi M, Choi YB, Lipton SA. 1996. NMDA receptors: from genes to channels. Trends Pharmacol Sci 17: 348-355.
16. Sugaya K, Hashimoto F, Ono M, Ito Y, Masuoka C, Nohara T. 1998. Antioxidative constituents from Leonurii Herba (Leonurus japonicus). Food Sci Technol Int Tokyo 4: 278-281.
17. Trist DG. 2000. Excitatory aminoacid agonists and antagonists: pharmacology and therapeutic applications. Pharm Acta Helv 74: 221-229.
18. Wang R, Zhou J, Tang XC. 2002. Tacrine attenuates hydrogen peroxide induced apoptosis by regulating expression of apoptosis related genes in rat PC12 cells. Brain Res Mol Brain Res 107: 1-8. (Pubitemid 35333199)
19. Widy-Tyszkiewicz E, Schminda R. 1997. A randomized double blind study of sedative effects of phytotherapeutic containing valerian, hops, balm, and motherwort versus placebo. Herba Pol 43: 154-159.
20. Xu HM, Lee CM, Hon PM, Chang HM. 1992. Proliferation of lymphocytes T and B by prehispanolone LC-5504 of Leonurus heterophyllus Sweet. Yao Hsue Hsue Pao 27: 812-816.