Antioxidant and hypolipidemic effect of Caralluma adscendens Roxb. in alloxanized diabetic rats

International Journal of Pharmacology

Volumn 6, Issue 4, 2010, Pages 362-368

  Tatiya, A U ^a   Kulkarni, A S ^a   Surana, S J ^a   Bari, N D ^a  

^a R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

Alloxan; Antidiabetic; Caralluma adscendens; Hypolipidemic; Oral glucose

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTIDIABETIC AGENT; BUTANOL; CARALLUMA ADSCENDENS EXTRACT; CHOLESTEROL; GLIBENCLAMIDE; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; METHANOL; PETROLEUM ETHER; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; WATER;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASCLEPIADACEAE; BODY WEIGHT; CARALLUMA ADSCENDENS; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG MECHANISM; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; IN VITRO STUDY; LIPID PEROXIDATION; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PLANT STEM; RAT;

EID: 77955630304     PISSN: 18117775     EISSN: 18125700     Source Type: Journal    
DOI: 10.3923/ijp.2010.400.406     Document Type: Article

References (43)

1. Al-Harbi, M.D., S. Qureshi, M.M. Ahmed, M. Afzal and A.H. Shah, 1994. Evaluation of Caralluma tuberculata pretreatment for the protection of rat gastric mucosa against toxic damage. Toxicol. Appl. Pharmacol., 28: 1-8.
2. Allain, C.C., L.S. Poom, C.S. Chan, W.S. Richmonal and P.C. Fu, 1974. Enzymatic determination of total serum cholesterol. Clin. Chem., 20: 470-475.
3. Amos, A.F., D J. McCarty and P. Zimmet, 1997. The rising global burden of diabetes and its complications: Estimates and projections to the year 2010. Diabet. Med., 14: S1-S85.
4. Ansari, N.M., L. Houlihan, B. Hussain and A. Pieroni, 2005. Antioxidant activity of five vegetables traditionally consumed by South-Asian migrants in Bradford, Yorkshire, UK. Phytother. Res., 19: 907-911.
5. Bader, A., A. Braca, N. Tommasi and I. Morelli, 2003. Further constituents from Caralluma negevensis. Phytochemistry, 62: 1277-1281.
6. Blois, M.S., 1958. Antioxidant determination of the use of stable free radical. Nature, 18:1199-1200.
7. Bnouham, M., F.Z. Merhfour, A. Ziyat, H. Mekhfi, M. Aziz and A. Legssyer, 2003. Antihyperglycemic activity of the aqueous extract of Urtica dioica. Fitoterpia, 74: 677-681.
8. Bruneton, J., 1999. Phytochemistry, Medicinal Plants. 2nd Edn., Lavoiser Publishing, France, pp: 324.
9. Feldman, D.L., T.C. Mogelesky, R. Sharif, W. Sawyer and M. Jeune, 1999. The in vitro and ex vivo antioxidant properties and hypolipidemic activity of CGP 2881. Atherosclerosis, 144: 343-355.
10. Friedewald, W.T., R.I. Levy and D.S. Fredrickson, 1972. Estimation of the concentration of LDL cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem., 18: 499-502.
11. Gupta, M.P., N.G. Soils, M. Esposito and S. Sanchez, 1984. Hypoglycemic activity of Neurolaena lobata (L.). J. Ethnopharmacol., 10: 323-327.
12. Holman, R.R. and R.C. Turner, 1991. Oral Agents and Insulin in the Treatment of NIDDM. In: Textbook of Diabetes, Pickup, J. and G. Wiliams (Eds.). Blackwell, Oxford, ISBN: 9780632059157, pp: 467-469.
13. Ivorra, M.D., M. Paya and A. Villar, 1989. A review of natural products and plants as potential antidiabetic drugs. J. Ethnopharmacol., 27: 243-275.
14. Jayakar, B., B. Rajkapoor and B. Suresh, 2004. Effect of Caralluma attenuata in normal and alloxan induced diabetic rats. J. Herb Phamacother., 4: 35-40.
15. Joy, K.L. and R. Kuttan, 1999. Antidiadetic activity of Picrorrhiza kurroa extract. J. Ethanopharmacol., 167: 143-148.
16. Kokate, C.K., 2006. Practical Pharmacognosy. 4th Edn., Vallabh Prakashan, Pune, India, pp: 107-108.
17. Krishnakumar, K., K.T. Augusti and P.L. Vijayammal, 2000. Hypolipidaemic effect of Salacia oblonga Wall, root bark in streptozotocin diabetic rats. Med. Sci. Res., 28: 65-67.
18. Kumar, R.S., T. Sivakumar, R.S. Sunderam, M. Gupta and U.K. Mazumder et al., 2005. Antioxidant and antimicrobial activities of Bauhinia racemosa L. stem bark. Brazilian J. Med. Biol. Res., 38: 1015-1024.
19. Momo, C.E.N., J.E. Oben, D. Tazoo and E. Dongo, 2006. Anti-diabetic and hypolipidemic effects of Laportea ovalifolia (Urtecaceae) in alloxan induced diabetic rats. Afr. J. Trad. CAM., 3: 36-43.
20. Mondal, S.K. and U.K. Muzumdar, 2006. In vitro antioxidant activity of Diospyros malabarica Kostel bark. Ind. J. Exp. Biol., 44: 39-44.
21. Muller, P.H., R.M. Schmulling, H.M. Licbich and M. Eggstgein, 1977. A fully enzymatic triglyceride determination. J. Clin. Chem. Clin. Biochem., 15: 457-464.
22. Nagappa, A.N., P.A. Thakurdesai, N. V. Rao and J. Singh, 2003. Antidiabetic acitivity of Termaninalia catappa Linn Fruits. J. Ethnopharmacol., 88: 45-50.
23. Naziroglu, M. and P.J. Butterworth, 2005. Protective effects of moderate exercise with dietary vitamin C and E on blood antioxidative defense mechanism in rats with streptozotocin-induced diabetes. Can. J. Appl. Physiol., 30: 172-185.
24. Ohkawa, H., N. Ohishi and K. Yagi, 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95: 351-358.
25. Oyaizu, M., 1986. Studies on product of browning reaction prepared from glucose amine. Jap. J. Nutr., 44: 307-315.
26. Paolisso, G., A. De Am ore, Di Maro, G.D. Maro and F. D'Onofrio, 1993. Evidence for relationship between free radicals and insulin action in the elderly. Metabolism, 42: 659-663.
27. Rahman, Q. and K. Zaman, 1989. Medicinal plants with hypoglycemic activity. J. Ethnopharmacol., 26: 1-55.
28. Ramesh, M., Y.N. Rao, A.V. Rao, M.C. Prabhakar, C.S. Rao, N. Muralidhar and B.M. Reddy, 1998. Antinociceptive and anti-inflammatory activity of a flavonoid isolated from Caralluma attenuata. J. Ethnopharmacol., 62: 63-66.
29. Rao, K.B., R. Giri, M.M. Kesavulu and C.H. Apparao, 1997. Herbal medicine: In the management of diabetes mellitus. Manphar Vaidhya Patrica, 1: 33-35.
30. Roeschlau, P., P. Bernt and W. Gruber, 1974. Enzymatic determination of total cholesterol in serum. Z. Klin. Chem. Klin. Biochem., 12: 226-226.
31. Sokeng, S.D., B. Rokeya, M. Mostafa, N. Nahar, M. Mosihuzzaman, L. Ali and P. Kamatchouing, 2005. Antihyperglycemic effect of Bridelia ndellensis ethanol extract and fraction in streptozotocin-induced diabetic rats. Afr. J. Trad Cam., 2: 94-102.
32. Syiem, D., G. Syngai, P.Z. Khup, B.S. Khongwir, B. Kharbuli and H.Kayang, 2002. Hypoglycemic effects of Potentilla fulgens L. in normal and alloxan induced diabetic mice. J. Ethnopharmacol., 83: 55-61.
33. Szudelski, T., 2001. The mechanism of alloxan and streptozotocin action in a cells of the rat pancreas. Physiol. Res., 50: 536-546.
34. The Wealth of India Raw Material, 1992. Publication and informative informative directorate (CSIR). New Delhi, 3: 266-267.
35. Trease, G.E. and I.C. Evans, 1983. Textbook of Pharmacognosy. 12th Edn., Bailliere Tindall, London, pp: 21-22.
36. Trinder,P., 1969. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J. Clin. Pathol., 22: 158-161.
37. Valiathan, M.S., 1998. Healing plants. Curr. Sci., 72: 1112-1126.
38. Velazquez, E., H.A. Tournier, P. Mordujovich de Bushiazzo, G. Saavedra and G.R. Schinella, 2003. Antioxidant activity of Paraguayans plant extracts. Fitoterapia, 74: 91-97. Venkatesh, S., G.D. Reddy, B.M. Reddy, M. Ramesh and A.V.N. Apparao, 2003. Antihyperglycemic activity of Carulluma asttenuate. Fitoterapia, 74: 274-279.
39. Venkatesh, S., G.D. Reddy, B.M. Reddy, M. Ramesh and A.V.N. Apparao, 2003. Antihyperglycemic activity of Carulluma asttenuate. Fitoterapia, 74: 274-279.
40. Wadood, A., N. Wadood and S.A. Wahid Shah, 1989. Effects of Acacia arabica and Caralluma edulis on blood glucose levels of normal and diabetic rabbits. J. Pak. Med. Assoc., 39: 208-2121.
41. Yokozawa, T., C.P. Chen, E. Dong, T. Tanaka, G.I. Nonaka and I. Nishioka, 1998. Study on the inhibitoiy effect of tannins and flavonoids against the 1,1-diphenyl-2 picrylhydrazyl radical. Biochem. Pharmacol., 56: 213-222.
42. Zakaria, M.N., M.W. Islam, R. Radhakrishnan, H.B. Chen, M. Kamil, A.N. Al-Gifn and A. Chan-Attas, 2001. Antinociceptive and anti-inflammatoiy properties of Caralluma arabi. J. Ethnopharmacol., 76: 155-158.
43. Zakaria, M.N.M., M.W. Isran and R. Radhakrishnan, 2002. Anti-gastric ulcer and Cytoprotective properties of Caralluma arabica. Pharm Biol., 40: 225-230.