Biomimetic actinide chelators: An update on the preclinical development of the orally active hydroxypyridonate decorporation agents 3,4,3-LI(1,2-HOPO) and 5-LIO(ME-3,2-HOPO)

Health Physics

Volumn 99, Issue 3, 2010, Pages 401-407

  Abergel, Rebecca J ^a   Durbin, Patricia W ^a   Kullgren, Birgitta ^a   Ebbe, Shirley N ^a   Xu, Jide ^b   Chang, Polly Y ^a,c   Bunin, Deborah I ^c   Blakely, Eleanor A ^a   Bjornstad, Kathleen A ^a   Rosen, Chris J ^a   Shuh, David K ^a   Raymond, Kenneth N ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SRI INTERNATIONAL   (United States)

Author keywords

actinides; chelation; contamination; internal; toxicology

Indexed keywords

4 CARBAMOYL 3 HYDROXY 1 METHYL 2(1H) PYRIDINONE; 4-CARBAMOYL-3-HYDROXY-1-METHYL-2(1H)-PYRIDINONE; ACTINIDE; BIOMIMETIC MATERIAL; CHELATING AGENT; LIGAND; LITHIUM; ORGANOMETALLIC COMPOUND; PENTETIC ACID; PYRIDONE DERIVATIVE;

CELL LINE; CHEMISTRY; CONFERENCE PAPER; DOSE RESPONSE; DRUG EFFECT; DRUG SCREENING; HUMAN; METHODOLOGY; ORAL DRUG ADMINISTRATION; SYNTHESIS; TIME; WASTE MANAGEMENT; DRUG EFFECTS; PROCEDURES;

ACTINOID SERIES ELEMENTS; ADMINISTRATION, ORAL; BIOMIMETIC MATERIALS; CELL LINE; CHELATING AGENTS; DECONTAMINATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; LIGANDS; LITHIUM; ORGANOMETALLIC COMPOUNDS; PENTETIC ACID; PYRIDONES; TIME FACTORS;

RATTUS;

EID: 77955626435     PISSN: 00179078     EISSN: None     Source Type: Journal    
DOI: 10.1097/HP.0b013e3181c21273     Document Type: Conference Paper

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