Topical treatment of klebsiella pneumoniae B5055 induced burn wound infection in mice using natural products

Journal of Infection in Developing Countries

Volumn 4, Issue 6, 2010, Pages 367-377

  Kumari, Seema ^a   Harjai, Kusum ^a   Chhibber, Sanjay ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Aloe vera gel; Honey; HPMC hydrogel; Klebsiella pneumoniae

Indexed keywords

ALOE VERA EXTRACT; HYDROXYPROPYLMETHYLCELLULOSE; PROBIOTIC AGENT; BIOLOGICAL PRODUCT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIOPHAGE; BACTERIOPHAGE KPN5; BURN; CONTROLLED STUDY; DRUG EFFICACY; DRUG STABILITY; HONEY; HYDROGEL; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MORTALITY; MOUSE; NONHUMAN; SKIN; TOXICITY TESTING; WOUND INFECTION; ALOE; ANIMAL; BAGG ALBINO MOUSE; BIOLOGICAL THERAPY; COMPARATIVE STUDY; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HUMAN; KLEBSIELLA INFECTIONS; PROCEDURES; TOPICAL DRUG ADMINISTRATION; VIROLOGY;

ALOE VERA; KLEBSIELLA; KLEBSIELLA PNEUMONIAE; MUS;

ADMINISTRATION, TOPICAL; ALOE; ANIMALS; BACTERIOPHAGES; BIOLOGICAL PRODUCTS; BIOLOGICAL THERAPY; BURNS; DISEASE MODELS, ANIMAL; HONEY; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; MICE; MICE, INBRED BALB C; WOUND INFECTION;

EID: 77955624517     PISSN: 20366590     EISSN: 19722680     Source Type: Journal    
DOI: 10.3855/jidc.312     Document Type: Article

References (53)

1. Honari S (2004) Topical therapies and antimicrobials in the management of burn wounds. Crit Care Nurs Clin N Am 16: 1-11.
2. Vindenes H, and Bjerknes R (1995) Microbial colonization of large wounds. Burns 21: 575-579.
3. de Gracia CG (2001) An open study comparing topical silver sulfadiazine and topical silver sulfadiazine-cerium nitrate in the treatment of moderate and severe burns. Burns 27: 67-74.
4. Ozumba UC and Jiburum BC (2000) Bacteriology of burn wounds in Enugu, Nigeria. Burns 26: 178-180.
5. Kaushik R, Kumar S, Sharma R, Lal P (2001) Bacteriology of burn wounds - the first three years in a new burn unit at the Medical College Chandigarh. Burns 27: 595-597.
6. Church D, Elsayed S, Reid O, Winston B, Lindsay R (2006) Burn wound infections. Clin Microbiol Rev 19: 403-434.
7. Manafi A, Hashemlou A, Momeni P, Moghimi HR (2008) Enhancing drugs absorption through third-degree burn wound eschar. Burns 34: 698-702.
8. Ollstein RN and McDonald C (1980) Topical and systemic antimicrobial agents in burns. Ann Plast Surg 5: 386-392.
9. Noronha C, and Almeida A (2000) Local burn treatment - topical antimicrobial agents. Ann Burns Fire Disasters vol. XIII n.4.
10. Heggers JP, Sazy JA, Stenberg BD, Strock LL, McCauley RL, Herndon DN, Robson MC (1991) Bactericidal and wound-healing properties of sodium hypochlorite solutions: The 1991 Lindberg Award. J Burn Care Research 12: 420-424.
11. Steen M (1993) Review of the use of povidone-iodine (PVP-I) in the treatment of burns. Postgrad Med J 69: S84-S92.
12. Ward RS and Saffle JR (1995) Topical agents in burn and wound care. Phys Ther 75: 526-538.
13. Snelling CFT, Ronal AR, Waters WR, Yaworski DS, Drulak K, Sunderland M (1978) Comparison of silver sulphadiazine and gentamicin for topical prophylaxis against burn wound sepsis. Can Med Assoc J 119: 466-470.
14. Jacob SE and James WD (2004) From road rash to top allergen in a flash: bacitracin. Dermatol Surg 30(4 Pt 1): 521-524.
15. Moyer CA, Brentano L, Gravens DL, Margraf NW, Manafo WW (1965) Treatment of large human burns with 5% silver nitrate solution. Arch Surg 90: 812-867.
16. Fox C (1968) Silver sulphadiazine: a new topical therapy for Pseudomonas in burns. Arch Surg 96: 184.
17. Shukla I, Tiwari R, Agrawal M (2004) Prevalence of extended spectrum β-lactamase producing Klebsiella pneumoniae in a tertiary care hospital. Ind J Med Microbiol 22: 87-91.
18. Ndayisaba G, Bazira L, Habonimana E (1992) Treatment of wounds with honey. 40 cases. Presse Med 21: 1516-1518.
19. Zumla A and Lulat A (1989) Honey - a remedy rediscovered. J R Soc Med 82: 384-385.
20. Subrahmanyam M, Sahapure AG, Nagane, NS, Bhagwat VR, Ganu JV (2001) Effects of topical application of honey on burn wound healing. Ann Burns Fire Disasters vol. XIV n.3.
21. Jalali FSS, Saifzadeh S, Tajik H, Farshid AA (2007) Experimental evaluation of repair process of burn-wounds treated with natural honey. J Ani Veter Adv 6: 179-184.
22. Kawai K, Beppu H, Shimpo K, Chihara T, Yamamoto N, Aggatsu T, Ueda H, Yamada Y (1998) In vivo effects of Aloe arborescens Miller var natalensis Berger (Kidachi aloe) on experimental Tinea Pedis in guinea pig feet. Phytotherapy Research 12: 178-182.
23. Tizard I, Busbee D, Maxwell B, Kemp MC (1994) Effects of Acemannan, a complex carbohydrate, on wound healing in young and aged rats. Wounds 6: 201-209.
24. Somboonwong J, Thanamittramanee S, Jariyaponhskul A, Patumraj S (2000) Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. J Med Assoc Thailand 83: 417-425.
25. Pribitkin ED, Boger G (2001) Herbal therapy: What every facial plastic surgeon must know. Arch Facial Plast Surg 3: 127-132.
26. Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C (2007) The efficacy of aloe vera used for burn wound healing: A systematic review. Burns 33: 713-718.
27. Hanlon GW (2007) Bacteriophages: an appraisal of their role in the treatment of bacterial infections. Int J Antimicrob Agents 30: 118-128.
28. Skurnik M, Pajunen M, Kiljunen S (2007) Biotechnological challenges of phage therapy. Biotechnol Lett 29: 995-1003.
29. Chhibber S, Kaur S, Kumari S (2008) Therapeutic potential of bacteriophage in treating Klebsiella pneumoniae B5055-mediated lobar pneumonia in mice. J Med Microbiol 57: 1508-1513.
30. Abul-Hassan HS, El-Tahan K, Massoud B, Gomaa R (1990) Bacteriophage therapy of Pseudomonas burn wound sepsis. Ann MBC vol. 3 n.4.
31. Matsuzaki S, Rashel M, Uchiyma J, Ujihara T, Kuroda M, Ikeuchi M, Fujieda M, Wakiguchi J, Imai S (2005) Bacteriophage therapy: a revitalized therapy against bacterial infectious diseases. J Infect Chemother 11: 211-219.
32. Madan J, Sharma AK, Inamdar N, Rao HS, Singh R (2008) Immunomodulatory properties of aloe vera gel in mice. Int J green Pharmacy 2: 152-154.
33. Dale RMK, Schnell G, Wong JP (2004) Therapeutic efficacy of "Nubiotics" against burn wound infection by Pseudomonas aeruginosa. Antimicrob Agents Chemother 48: 2918-2923.
34. Adam MH (1959) Bacteriophages, Interscience Publishers, New York, NY, 450- 456.
35. Kumari S, Harjai K, Chhibber S (2009) Efficacy of bacteriophage treatment in murine burn wound infection induced by Klebsiella pneumoniae. J Microbiol Biotechnol 19: 622-628.
36. Cooper JW and Gunn C (1989) Dispensing for pharmaceutical students. 12th edition by Carter SJ, CBS publication p. 192-231.
37. Basketter DA, York M, McFadden JP, Robinson MK (2004) Determination of skin irritation potential in the human 4-h patch test. Contact Dermatitis 51: 1-4.
38. Subrahmanyam M (1996) Honey dressing versus boiled potato peel in the treatment of burns: A prespective randomised study. Burns 22: 491-493.
39. Bangroo AK, Khatri R, Chauhan S (2005) Honey dressing in pediatric burns. J Ind Assoc Pediat Surg 10: 172-175.
40. Molan PC and Betts JA (2004) Clinical usage of honey as a wound dressing: An update. J Wound Care 13(9): 353-356.
41. Lusby PE and Coombes A, Wilkinson JM (2002) Honey: A potent agent for wound healing? J Wound Ostomy Continence Nurs 29: 295-300.
42. Visavadia BG, Honeysett J, Danford MH (2008) Manuka honey dressing: An effective treatment for chronic wound infections. Br J Oral Maxillofac Surg 46: 55-56.
43. Natarajan S, Williamson D, Grey JA, Harding KG, Cooper RA (2001) Healing of an MRSA colonized, hydroxyurea- induced leg ulcer with honey. J Dermat Treat 12: 33- 36.
44. Tonks AJ, Cooper RA, Jones KP, Blair S, Parton J, Tonks A (2003) Honey stimulates inflammatory cytokine production from monocytes. Cytokine 21: 242-247.
45. Chirife J, Herszage L, Joseph A, Kohn ES (1983) In vitro study of bacterial growth inhibition in concentrated sugar solutions: microbiological basis for the use of sugar in treating infected wounds. Antimicrob Agents Chemother 23: 766-773.
46. Abd-El Aal AM, El-Hadidy MR, El-Mashad NB, El-Sebaie AH (2007) Antimicrobial effect of bee honey in comparison to antibiotics on organisms isolated from infected burns. Ann Burns Fire Disasters vol. XX n.2.
47. Subrahmanyam M, Hemmady AR, Pawar SG (2003) Multidrug-resistant Staphylococcus aureus isolated from infected burns sensitive to honey. Ann Burns Fire Disasters 16: 192-4.
48. Bodeker GC, Ryan TJ, Ong CK (1999) Traditional Approaches to Wound Healing. Clin Dermatol 17: 93-98.
49. Reynolds T and Dweck AC (1999) Aloe vera leaf gel: A review update. J Ethnopharmacol 68: 3-37.
50. Kaufman T, Newman AR, Wexler MR (1989) Aloe vera and burn wound healing. Plast Reconst Surg 83: 1075-1076.
51. Pandey R and Mishra A (2009) Antibacterial activities of crude extract of Aloe barbadensis to clinically isolated bacterial pathogens. Appl Biochem Biotechnol (DOI 10.1007/s12010-009-8577-0).
52. Schulz V, Hansel R, Blumenthal M, Tyler V (2004) Rational Phytotherapy: a reference guide for physicians and pharmacists. Berlin, Springer, 344.
53. Thomas S and Hay P (1995) Fluid handling properties of hydrogel dressings. Ostomy Wound Manage 41: 54-6, 58-9.