Therapeutic efficacy of "nubiotics" against burn wound infection by Pseudomonas aeruginosa

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 8, 2004, Pages 2918-2923

  Dale, Roderic M K ^a   Schnell, Glen ^b   Wong, Jonathan P ^a,b  

^a Oligos Etc Inc   (United States)

^b DEFENCE RESEARCH AND DEVELOPMENT CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CIPROFLOXACIN; NUBIOTIC; NUBIOTIC AUG; NUBIOTIC G; NUBIOTIC GGG; NUBIOTIC NU 1; NUBIOTIC NU 2; NUBIOTIC UMP; NUBIOTIC UUU; NUCLEIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIUM ISOLATE; BURN; CONTROLLED STUDY; ERADICATION THERAPY; LETHAL DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; PSEUDOMONAS AERUGINOSA; SURVIVAL RATE; WOUND INFECTION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; BURNS; CIPROFLOXACIN; DRUG COMPOUNDING; EXCIPIENTS; FEMALE; LACTOSE; LIPOSOMES; METHYLCELLULOSE; MICE; MICE, INBRED BALB C; NUCLEOTIDES; OXAZINES; PSEUDOMONAS INFECTIONS; SURVIVAL ANALYSIS; WOUND INFECTION;

EID: 3342929402     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.8.2918-2923.2004     Document Type: Article

References (17)

1. Bowler, P. 1998. The anaerobic and aerobic microbiology of wounds: a review. Wounds 10:170-178.
2. Bowler, P. G., and B. J. Davies. 1999. The microbiology of acute and chronic wounds. Wounds 11:72-78.
3. Charoo, N. A., K. Kohli, and A. Ali. 2003. Preparation of in situ-forming gels of ciprofloxacin hydrochloride for the treatment of bacterial conjunctivitis: in vitro and in vivo studies. J. Pharm. Sci. 92:407-413.
4. Dulbecco, R., and H. S. Ginsberg. 1980. The nature of viruses, p. 853-856. In B. D. Davies, R. Dulbecco, H. N. Eisen, and H. S. Ginsberg (ed.), Microbiology. Harper & Row, Philadelphia, Pa.
5. Edlich, R. F., G. T. Rodeheaver, and J. G. Thacker. 1991. Wounds, bites, and stings, p. 715-726. In E. E. Moore, K. L. Mattox, and D. V. Feliciano (ed.), Trauma. Appleton & Lange, Norwalk, Conn.
6. Gentry, L. O. 1993. Treatment of skin and soft tissue infections with quinolone antimicrobial agents, p. 413-422. In D. C. Hooper and J. S. Wolfson (ed.), Quinolone antimicrobial agents. American Society of Microbiology, Washington, D.C.
7. Green, J. W., and R. P. Wenzel. 1977. Postoperative wound infection: a controlled study of the increased duration of hospital stay and direct cost of hospitalization. Ann. Surg. 185:264-268.
8. Heggars, J. P., C. Vilarreal, S. Wolf, G. L. Klein, S. D. John, M. Desal, and D. N. Herndon. 1998. Ciprofloxacin as a therapeutic modality in pediatric burn wound infections. Arch. Surg. 133:1247-1250.
9. Holder, I. A. 1985. The pathogenesis of infections owing to Pseudomonas aeruginosa using the burned mouse model: experimental studies from the Shriners Burns Institute, Cincinnati. Can. J. Microbiol. 31:393-402.
10. Klein, D. G., D. E. Fritsh, and S. G. Amin. 1995. Wound infection following trauma and burn injuries. Crit. Care Nursing N. Am. 7:627-642.
11. Larson, E. L., C. Gomez-Duarre, L. V. Lee, D. J. Kain, and B. H. Keswiek. 2002. Microbial flora of the hands of homemakers. Am. J. Infect. Control 31:72-79.
12. Oh, Y.-K., D. E. Nix, and R. B. Staubinger. 1995. Formulation and efficacy of liposome-encapsulated antibiotics for the therapy of intracellular Mycobacterium avium infection. Antimicrob. Agents Chemother. 39:2104-2111.
13. Parry, M. F., K. B. Panzer, and M. E. Yukna. 1989. Quionolone resistance: susceptibility data from a 300-bed community hospital. Am. J. Med. 87(Suppl. 5A):12-16.
14. Pruitt, B. A., A. T. McManus, S. H. Kim, and C. W. Goodwin. 1998. Burn wound infections: current status. World J. Surg. 22:135-145.
15. Pruitt, B. A., and A. T. McManus. 1992. The changing epidemiology of infection in burn patients. World J. Surg. 16:57-67.
16. Wurtz, R., E. Karajovic, E. Dacumos, and M. Hanumandass. 1995. Nosocomial infections in a burn intensive care unit. Burns 21:180-184.
17. Wong, J. P., J. W. Cherwonogrodzky, V. L. Di Ninno, R. Dela Cruz, and E. G. Saravolac. 1995. Liposome-encapsulated ciprofloxacin for the prevention and treatment of infectious diseases by intracellular pathogens, p. 105-120. In P. N. Shek (ed.), Liposomes in biomedical applications. Harwood Academic Press, Amsterdam, The Netherlands.