A new look at the pathogenesis of the meconium aspiration syndrome: A role for fetal pancreatic proteolytic enzymes in epithelial cell detachment

Pediatric Research

Volumn 68, Issue 3, 2010, Pages 221-224

  Ivanov, Vadim A ^a   Gewolb, Ira H ^a   Uhal, Bruce D ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

[4(2 AMINOETHYL) BENZENESULFONYL FLUORIDE HYDROCHLORIDE]; AMINOCAPROIC ACID; APROTININ; BENZAMIDINE; CHYMOSTATIN; CRYSTAL VIOLET; LEUPEPTIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PHOSPHAMIDON; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BASEMENT MEMBRANE; CELL DEATH; EPITHELIUM CELL; HUMAN; HUMAN CELL; LIGHT ABSORPTION; LUNG INJURY; MECONIUM ASPIRATION; NEWBORN; PATHOGENESIS; PRIORITY JOURNAL; STAINING;

ANALYSIS OF VARIANCE; CELL ADHESION; CELL LINE; EPITHELIAL CELLS; GENTIAN VIOLET; HUMANS; INFANT, NEWBORN; MECONIUM; MECONIUM ASPIRATION SYNDROME; MICROSCOPY, PHASE-CONTRAST; OLIGOPEPTIDES; PEPTIDE HYDROLASES; PROTEASE INHIBITORS;

EID: 77955604313     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3181ebd4c3     Document Type: Article

References (14)

1. Gelfand SL, Fanaroff JM, Walsh MC 2004 Controversies in the treatment ofmeconium aspiration syndrome. Clin Perinatol 31:445-452
2. Hofmeyr GJ 2009 What (not) to do before delivery? Prevention of fetal meconiumrelease and its consequences. Early Hum Dev 85:611-615
3. De Beaufort AJ 2009 Early human development at the perinatal interface: meconiumstained amniotic fluid (MSAF) and meconium aspiration syndrome (MAS). EarlyHum Dev 85:605Kääpä PO 2009 Meconium aspiration syndrome (MAS)-where do we go? Researchperspectives. Early Hum Dev 85:627-629
4. Ivanov VA 2006 Meconium aspiration syndrome treatment-new approaches usingold drugs. Med Hypotheses 66:808-810
5. Lankisch PG 1982 Exocrine pancreatic function tests. Gut 23:777-798
6. Mullinger M, Palasi M 1966 Tryptic and chymotryptic activity of stools of newborninfants. Pediatrics 38:657-659
7. Bergmeyer HU, Gawehn K 1974 Methods of Enzymatic Analysis. Academic Press,New York, NY, pp 1008, 1019
8. Antonowicz I, Shwachman H 1979 Meconium in health and in disease. Adv Pediatr26:275-310
9. Harries JT 1978 Meconium in health and disease. Br Med Bull 34:75-78
10. Walker WA, Durie P, Hamilton JR, Walker-Smith JA, Watkins JB 1991 PediatricGastrointestinal Disease: Pathophysiology, Diagnosis, Management. B.C. Decker,Philadelphia, PA, pp 274
11. Marrion RM, Riley L 2000 Detection of cell detachment activity induced byMoraxella bovis. Am J Vet Res 61:1145-1149
12. Zagariya A, Bhat R, Uhal B, Navale S, Freidine M, Vidyasagar D 2000 Cell deathand lung cell histology in meconium aspirated newborn rabbit lung. Eur J Pediatr159:819-826
13. Mokra D, Tonhajzerova I, Mokry J, Drgova A, Petraskova M, Calkovska A, JavorkaK 2008 Rapid cardiovascular effects of dexamethasone in rabbits with meconiuminducedacute lung injury. Can J Physiol Pharmacol 86:804-814
14. Zagariya A, Bhat R, Chari G, Uhal B, Navale S, Vidyasagar D 2005 Apoptosis ofairway epithelial cells in response to meconium. Life Sci 76:1849-1858