Protective effects of a gastrointestinal agent containing Korean red ginseng on gastric ulcer models in mice

BMC Complementary and Alternative Medicine

Volumn 10, Issue , 2010, Pages

  Oyagi, Atsushi ^a   Ogawa, Kenjirou ^a   Kakino, Mamoru ^a   Hara, Hideaki ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ATRACTYLODES EXTRACT; CHLORIDE; CINNAMON EXTRACT; CORYDALIS EXTRACT; GASTROINTESTINAL AGENT; GINSENG EXTRACT; HERBACEOUS AGENT; INDOMETACIN; KOREAN RED GINSENG CONTAINING DRUG; MAGNESIUM HYDROXIDE; PLANT EXTRACT; SELBELLE; SOZINSAN AT; TEPRENONE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG; ANTIOXIDANT; ANTIULCER AGENT; HYDROCHLORIC ACID; SAPONIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; CORYDALIS; DOPPLER FLOWMETRY; HISTOPATHOLOGY; LIPID PEROXIDATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; STOMACH MUCOSA BLOOD FLOW; STOMACH PROTECTION; STOMACH ULCER; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECT; GINSENG; STOMACH MUCOSA; VASCULARIZATION;

ANIMALS; ANTI-ULCER AGENTS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; DRUGS, CHINESE HERBAL; ETHANOL; GASTRIC MUCOSA; HYDROCHLORIC ACID; INDOMETHACIN; MALE; MICE; OXIDATIVE STRESS; PANAX; SAPONINS; STOMACH ULCER;

EID: 77955595945     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-10-45     Document Type: Article

References (32)

1. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999, 58:1685-1693. 10.1016/S0006-2952(99)00212-9, 10571242.
2. Tachikawa E, Kudo K, Harada K, Kashimoto T, Miyate Y, Kakizaki A, Takahashi E. Effects of ginseng saponins on responses induced by various receptor stimuli. Eur J Pharmacol 1999, 369:23-32. 10.1016/S0014-2999(99)00043-6, 10204677.
3. Yun TK. Brief introduction of Panax ginseng C.A. Meyer. J Korean Med Sci 2001, 16(Suppl):S3-5.
4. Morisaki N, Watanabe S, Tezuka M, Zenibayashi M, Shiina R, Koyama N, Kanzaki T, Saito Y. Mechanism of angiogenic effects of saponin from ginseng Radix rubra in human umbilical vein endothelial cells. Br J Pharmacol 1995, 115:1188-1193. 1908790, 7582543.
5. Konoshima T, Takasaki M, Tokuda H, Nishino H, Duc NM, Kasai R, Yamasaki K. Anti-tumor-promoting activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. (I). Biol Pharm Bull 1998, 21:834-838.
6. Alqasoumi S, Al-Sohaibani M, Al-Howiriny T, Al-Yahya M, Rafatullah S. Rocket "Eruca sativa": a salad herb with potential gastric anti-ulcer activity. World J Gastroenterol 2009, 15:1958-1965. 10.3748/wjg.15.1958, 2675085, 19399927.
7. Mizui T, Sato H, Hirose F, Doteuchi M. Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats. Life Sci 1987, 41:755-763. 10.1016/0024-3205(87)90456-5, 3613839.
8. Suh SO, Kroh M, Kim NR, Joh YG, Cho MY. Effects of red ginseng upon postoperative immunity and survival in patients with stage III gastric cancer. Am J Chin Med 2002, 30:483-494. 10.1142/S0192415X02000661, 12568276.
9. Matsuda H, Kubo M. Pharmacological study on Panax ginseng C. A. Meyer. II. Effects of red ginseng on the experimental gastric ulcer (1). Yakugaku Zasshi 1984, 104:449-453.
10. Lulu DJ, Dragstedt LR. 2nd: Massive bleeding due to acute hemorrhagic gastritis. Arch Surg 1970, 101:550-554.
11. Eastwood GL, Kirchner JP. Changes in the fine structure of mouse gastric epithelium produced by ethanol and urea. Gastroenterology 1974, 67:71-84.
12. Tarnawski A, Stachura J, Ivey KJ, Mach T, Bogdal J, Klimczyk B. Ethanol induced duodenal lesions in man. Protective effect of prostaglandin. Prostaglandins 1981, 21(Suppl):147-153. 10.1016/0090-6980(81)90131-3, 7302259.
13. Szabo S, Brown A. Prevention of ethanol-induced vascular injury and gastric mucosal lesions by sucralfate and its components: possible role of endogenous sulfhydryls. Proc Soc Exp Biol Med 1987, 185:493-497.
14. Simmons DL, Botting RM, Hla T. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 2004, 56:387-437. 10.1124/pr.56.3.3, 15317910.
15. Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 1999, 340:1888-1899. 10.1056/NEJM199906173402407, 10369853.
16. Singh G, Fries JF. Famotidine to prevent peptic ulcer caused by NSAIDs. N Engl J Med 1996, 335:1322-1323. 1322; author reply, 10.1056/NEJM199610243351714, 8992334.
17. Morimoto Y, Shimohara K, Oshima S, Hara H, Sukamoto T. Effects of KB-5492, a new anti-ulcer agent with a selective affinity for the sigma-receptor, on aspirin-induced disruption of the rat gastric mucosal barrier. Jpn J Pharmacol 1994, 64(1):49-55. 10.1254/jjp.64.49, 8164393.
18. Mizui T, Shimono N, Doteuchi M. A possible mechanism of protection by polyamines against gastric damage induced by acidified ethanol in rats: polyamine protection may depend on its antiperoxidative properties. Jpn J Pharmacol 1987, 44(1):43-50. 10.1254/jjp.44.43, 3041086.
19. Shujaa N, Zadori ZS, Ronai AZ, Barna I, Mergl Z, Mozes MM, Gyires K. Analysis of the effect of neuropeptides and cannabinoids in gastric mucosal defense initiated centrally in the rat. J Physiol Pharmacol 2009, 60(Suppl 7):93-100.
20. Holm-Rutili L, Berglindh T. Pentagastrin and gastric mucosal blood flow. Am J Physiol 1986, 250:G575-580.
21. Shaw S, Herbert V, Colman N, Jayatilleke E. Effect of ethanol-generated free radicals on gastric intrinsic factor and glutathione. Alcohol 1990, 7:153-157. 10.1016/0741-8329(90)90077-P, 2328089.
22. Dragland S, Senoo H, Wake K, Holte K, Blomhoff R. Several culinary and medicinal herbs are important sources of dietary antioxidants. J Nutr 2003, 133:1286-1290.
23. Stefek M, Benes L. Antioxidative activity of oren-gedoku-to (TJ-15) and toki-shakuyaku-san (TJ-23) in the liver microsomes of rats. Cesk Farm 1992, 41:250-252.
24. Tanaka S, Yoon YH, Fukui H, Tabata M, Akira T, Okano K, Iwai M, Iga Y, Yokoyama K. Antiulcerogenic compounds isolated from Chinese cinnamon. Planta Med 1989, 55(3):245-248. 10.1055/s-2006-961994, 2740458.
25. Nie SQ, Li TL, Jiang WJ, Xue BY, Liang AH, Li GQ, Yang Q. A comparative study on anti-ulcer action of unprepared and calcined oyster shell. Zhongguo Zhong Yao Za Zhi 1994, 19(7):405-407. 446.
26. Matsuda H, Kubo M. Pharmacological study on Panax ginseng C. A. Meyer. VI. Cardiovascular Effect of Red ginseng (1). Shoyakugaku Zasshi 1985, 39(4):277-281.
27. Lin YP, Yi SX, Yan J, Chang XR. Effect of acupuncture at Foot-Yangming Meridian on gastric mucosal blood flow, gastric motility and brain-gut peptide. World J Gastroenterol 2007, 13:2229-2233.
28. Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Schuppan D, Drozdowicz D, Ptak A, Pawlik M, Nakamura T, Hahn EG. Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor. J Physiol Pharmacol 2000, 51:751-773.
29. Pawlik M, Ptak A, Pajdo R, Konturek PC, Brzozowski T, Konturek SJ. Sensory nerves and calcitonin gene related peptide in the effect of ischemic preconditioning on acute and chronic gastric lesions induced by ischemia-reperfusion. J Physiol Pharmacol 2001, 52:569-581.
30. Kim CS, Park JB, Kim KJ, Chang SJ, Ryoo SW, Jeon BH. Effect of Korea red ginseng on cerebral blood flow and superoxide production. Acta Pharmacol Sin 2002, 23:1152-1156.
31. Jeon BH, Kim CS, Kim HS, Park JB, Nam KY, Chang SJ. Effect of Korean red ginseng on blood pressure and nitric oxide production. Acta Pharmacol Sin 2000, 21:1095-1100.
32. Chen X, Salwinski S, Lee TJ. Extracts of Ginkgo biloba and ginsenosides exert cerebral vasorelaxation via a nitric oxide pathway. Clin Exp Pharmacol Physiol 1997, 24:958-959. 10.1111/j.1440-1681.1997.tb02727.x, 9406663.