Plasma and liver proteomic analysis of 3Z-3-[(1H-pyrrol-2-yl)-methylidene]- 1-(1-piperidinylmethyl)-1,3-2H-indol-2-one-induced hepatotoxicity in Wistar rats

Proteomics

Volumn 10, Issue 16, 2010, Pages 2927-2941

  Wang, Ying ^a,b   Yang, Baohua ^a   Wu, Chunqi ^a   Zheng, Zhibing ^a   Yuan, Ye ^a   Hu, ZhongHui ^a   Ma, HuaZhi ^a   Li, Song ^a   Liao, Mingyang ^a   Wang, Quanjun ^a  

^a BEIJING INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (China)

^b JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Animal proteomics; Biomarkers; Hepatotoxicity; MS; Z24

Indexed keywords

3-[(1H PYRROL 2 YL) METHYLIDENE] 1 (1-PIPERIDINYLMETHYL) 1,3 2H-INDOL 2 ONE; ANTINEOPLASTIC AGENT; BIOLOGICAL MARKER; PROTEOME; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; FATTY ACID OXIDATION; HISTOPATHOLOGY; LIVER LEVEL; LIVER MITOCHONDRION; LIVER TOXICITY; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEOMICS; RAT; WESTERN BLOTTING; WISTAR RAT;

AMINO ACIDS; ANIMALS; APOPTOSIS; BLOOD PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; FEMALE; HISTOCYTOCHEMISTRY; IN SITU NICK-END LABELING; LIVER; MASS SPECTROMETRY; MESYLATES; NADP; PROTEOME; PROTEOMICS; PYRROLES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES;

ANIMALIA; RATTUS; RATTUS NORVEGICUS; RODENTIA;

EID: 77955593674     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.200900699     Document Type: Article

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