Phosphorus and calcium metabolism and the cardiovascular system in patients with early-stage chronic renal disease

Terapevticheskii Arkhiv

Volumn 82, Issue 6, 2010, Pages 25-28

  Smirnov, Alexei V ^a   Volkov, M M ^a   Dobronravov, V A ^a   Rafraft, H ^a  

^a PAVLOV FIRST SAINT PETERSBURG STATE MEDICAL UNIVERSITY   (Russian Federation)

Author keywords

25(OH) vitamin D; Abdominal aortic calcification; Arterial hypertension; Cardiac valvular calcification; Heart failure; Parathyroid hormone; Phosphate

Indexed keywords

EID: 77955575493     PISSN: 00403660     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Vanholder R., Massy Z, Argiles A. et al. Chronic kidney disease as cause of cardiovascular morbidity and mortality. Nephrol. Dial. Transplant. 2005; 20 (6): 1048-1056.
2. Levin A., Bakris G. L., Molitch M. et ai. Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: Results of the study to evaluate early kidney disease. Kidney Int. 2007; 71: 31-38.
3. Voormolen N., Noordzij M., Grootendorst D. C. et al. High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients. Nephrol. Dial. Transplant. 2007; 22 (10): 2909-2916.
4. Kovesdy C. P., Ahmadadeh S., Anderson J. E., Kalantar-Zadeh K. Secondary hyperparathyroidism is associated with higher mortality in men with moderate to severe chronic kidney disease. Kidney Int. 2008; 73 (11): 1296-1302.
5. Ravani P., Malberti F., Tripepi G. et al. Vitamin D levels and patient outcome in chronic kidney disease. Kidney Int. 2009; 75 (1): 88-95.
6. Li Y. C., Kong J., Wei M. et al. 1,25-Dihydroxyvitamin Dj is a negative endocrine regulator of the renin-angiotensin system. J. Clin. Invest. 2002; 110: 229-238.
7. Mathieu C., Adorini L. The coming of age of 1,25-dihydroxyvi-tamin D(3) analogs as immunomodulatory agents. Trends Mol. Med. 2002; 8 (4): 174-179.
8. Park C. W., Oh Y. S., Shin Y. S. et al. Intravenous calcitriol regresses myocardial hypertrophy in hemodialysis patients with secondary hyperparathyroidism. Am. J. Kidney Dis. 1999; 33 (1): 73-81.
9. Zittermann A., Schleithoff S. S., Tenderich G. et al. Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure? J. Am. Coll. Cardiol. 2003; 41(1): 105-112.
10. Nasri H., Baradaran A. Close association between parathyroid hormone and left ventricular function and structure in end-stage renal failure patients under maintenance hemodialysis. J. Ayub. Med. Coll. Abbottabad. 2004; 16 (2): 3-8.
11. El-Abbadi M. M., Pai A. S., Leaf E. M. et al. Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and oste-opontin. Kidney Int. 2009; (12): 1297-1307.
12. Shioi A., Nishizawa Y. Roles of hyperphosphatemia in vascular calcification. Clin. Calcium. 2009; 19 (2): 180-185.
13. Mathew S., Tustison K. S., Sugatani T. et al. The mechanism of phosphorus as a cardiovascular risk factor in CKD. J. Am. Soc. Nephrol. 2008; 19 (6): 1092-1105.
14. Hak A. E., Pols H. A. P., van Hemert A. M. et al. Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study. Arterioscler. Thromb. Vase. Biol. 2000; 20: 1926-1931.
15. ZadshirA., Tareen N., Pan D. et al. The prevalence of hypovitaminosis D among US adults: data from the NHANES III. Ethn. Dis. 2005; 5 (4,suppl. 5): S97-S101.
16. Wehmeier K. R., Mazza A., Hachem S. et al. Differential regulation of apolipoprotein A-I gene expression by vitamin D receptor modulators. Biochim. Biophys. Acta 2008; 1780 (2): 264-273.
17. Linhartova K., Veselka J., Sterbakova G. et al. Parathyroid hormone and vitamin D levels are independently associated with calcific aortic stenosis. Circ. J. 2008; 72 (2): 245-250.
18. Joy M. S., Karagiannis P. C., Peyerl F. W. Outcomes of secondary hyperparathyroidism in chronic kidney disease and the direct costs of treatment. J. Manag. Care Pharm. 2007; 13 (5): 397-411.
19. Graciolli F. G., Neves K. R., dos Reis L. M. et al. Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia. Nephrol. Dial. Transplant. 2009; 24 (5): 1416-1421.
20. Rashid G., Bernheim J., Green J., Benchetrit S. Parathyroid hormone stimulates endothelial expression of atherosclerotic parameters through protein kinase pathways. Am. J. Physiol. Renal. Physiol. 2007; 292 (4): 1215-1218.
21. Bortotolotto L. A., Costa-Hong V., Jorgetti V. et al. Vascular changes in chronic renal disease patients with secondary hyperparathyroidism. J. Nephrol. 2007; 20 (1): 66-72.