Structural elucidation of process-related impurities in escitalopram by LC/ESI-MS and NMR

Journal of Pharmaceutical and Biomedical Analysis

Volumn 53, Issue 4, 2010, Pages 895-901

  Raman, Bhanu ^a   Sharma, Brajesh A ^a,b   Ghugare, Pradeep D ^b   Nandavadekar, Sanjay ^b   Singh, Dharmendra ^b   Karmuse, Pravin K ^b   Kumar, Ashok ^b  

^a K J Somaiya College of Science and Commerce   (India)

^b Ipca Laboratories Ltd   (India)

Author keywords

Escitalopram; Impurities; LC ESI MS; NMR; Semi preparative HPLC

Indexed keywords

BENZOFURAN DERIVATIVE; ESCITALOPRAM; N (CHLOROMETHYL) 3 [5 CYANO 1 (4 FLUOROPHENYL) 1,3 DIHYDRO 2 BENZOFURAN 1 YL] N,N DIMETHYLPROPAN 1 AMINIUM; N (CHLOROMETHYL) 4 [4 CYANO 2 (HYDROXYMETHYL)PHENYL] 4 (4 FLUOROPHENYL) 4 HYDROXY N,N DIMETHYLBUTAN 1 AMINIUM; NITRILE; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG IMPURITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; FLUORINE NUCLEAR MAGNETIC RESONANCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUADRUPOLE MASS SPECTROMETRY; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITALOPRAM; DRUG CONTAMINATION; MAGNETIC RESONANCE SPECTROSCOPY; SEROTONIN UPTAKE INHIBITORS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 77955563576     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2010.06.019     Document Type: Article

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