Maternal serum interleukin-6, c-reactive protein, and matrix metalloproteinase-9 concentrations as risk factors for preterm birth <32 weeks and adverse neonatal outcomes

American Journal of Perinatology

Volumn 27, Issue 8, 2010, Pages 631-639

  Sorokin, Yoram ^a   Romero, Roberto ^b   Mele, Lisa ^c   Wapner, Ronald J ^a,d   Iams, Jay D ^a,e   Dudley, Donald J ^a,f   Spong, Catherine Y ^b   Peaceman, Alan M ^a,g   Leveno, Kenneth J ^a,h   Harper, Margaret ^a,i   Caritis, Steve N ^a,j   Miodovnik, Menachem ^a,k,l   Mercer, Brian M ^a,m   Thorp, John M ^a,n   O'Sullivan, Mary Jo ^a,o   Ramin, Susan M ^a,p   Carpenter, Marshall W ^a,q   Rouse, Dwight J ^a,r   Sibai, Baha ^a,s  

^a WAYNE STATE UNIVERSITY   (United States)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c GEORGE WASHINGTON UNIVERSITY   (United States)

^d DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^e OHIO STATE UNIVERSITY   (United States)

^f UNIVERSITY OF UTAH   (United States)

^g NORTHWESTERN UNIVERSITY   (United States)

^h UNIVERSITY OF TEXAS AT DALLAS   (United States)

ⁱ WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^j UNIVERSITY OF PITTSBURGH   (United States)

^k Och Spine at New York Presbyterian Hospitals   (United States)

^l UNIVERSITY OF CINCINNATI   (United States)

^m CASE WESTERN RESERVE UNIVERSITY   (United States)

ⁿ UNIVERSITY OF NORTH CAROLINA   (United States)

^o UNIVERSITY OF MIAMI   (United States)

^p UNIVERSITY OF TEXAS   (United States)

^q BROWN UNIVERSITY   (United States)

^r UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^s UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

more..

Author keywords

cytokines; Maternal serum; neonatal morbidity; preterm birth

Indexed keywords

C REACTIVE PROTEIN; CORTICOSTEROID; GELATINASE B; INTERLEUKIN 6; PLACEBO;

ARTICLE; BRAIN HEMORRHAGE; CHRONIC LUNG DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MATERNAL SERUM; MULTICENTER STUDY; NECROTIZING ENTEROCOLITIS; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS SYNDROME; RISK FACTOR; SEPSIS;

EID: 77955540389     PISSN: 07351631     EISSN: 10988785     Source Type: Journal    
DOI: 10.1055/s-0030-1249366     Document Type: Article

References (39)

1. Goldenberg R L., Culhane J F., Iams J D., Romero R. Epidemiology and causes of preterm birth. Lancet 2008 371 75-84
2. Romero R, Gomez R, Ghezzi F et al. A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol 1998 179 186-193
3. Goldenberg R L., Hauth J C., Andrews W W. Intrauterine infection and preterm delivery. N Engl J Med 2000 342 1500-1507
4. Yoon B H., Jun J K., Romero R et al. Amniotic fluid inflammatory cytokines (interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha), neonatal brain white matter lesions, and cerebral palsy. Am J Obstet Gynecol 1997 177 19-26
5. Yoon B H., Romero R, Park J S. et al. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol 2000 182 675-681
6. Romero R, Espinoza J, Kusanovic J P. et al. The preterm parturition syndrome. BJOG 2006 113 (Suppl 3) 17-42
7. Romero R, Yoon B H., Mazor M et al. A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes. Am J Obstet Gynecol 1993 169 839-851 (Pubitemid 23317515)
8. Goepfert A R., Goldenberg R L., Andrews W W. et al, National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. The Preterm Prediction Study: association between cervical interleukin 6 concentration and spontaneous preterm birth. Am J Obstet Gynecol 2001 184 483-488
9. Yoon B H., Romero R, Kim C J. et al. Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity. Am J Obstet Gynecol 1995 172 960-970
10. Yoon B H., Yang S H., Jun J K., Park K H., Kim C J., Romero R. Maternal blood C-reactive protein, white blood cell count, and temperature in preterm labor: a comparison with amniotic fluid white blood cell count. Obstet Gynecol 1996a 87 231-237 (Pubitemid 26033138)
11. Yoon B H., Jun J K., Park K H., Syn H C., Gomez R, Romero R. Serum C-reactive protein, white blood cell count, and amniotic fluid white blood cell count in women with preterm premature rupture of membranes. Obstet Gynecol 1996b 88 1034-1040 (Pubitemid 26394307)
12. Martinez E, Figueroa R, Garry D et al. Elevated amniotic fluid interleukin-6 as a predictor of neonatal periventricular leukomalacia and intraventricular hemorrhage. J Matern Fetal Investig 1998 8 101-107
13. Weeks J W., Reynolds L, Taylor D, Lewis J, Wan T, Gall S A. Umbilical cord blood interleukin-6 levels and neonatal morbidity. Obstet Gynecol 1997 90 815-818
14. Goepfert A R., Andrews W W., Carlo W et al. Umbilical cord plasma interleukin-6 concentrations in preterm infants and risk of neonatal morbidity. Am J Obstet Gynecol 2004 191 1375-1381
15. Yoon B H., Romero R, Yang S H. et al. Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia. Am J Obstet Gynecol 1996 174 1433-1440
16. Kassal R, Anwar M, Kashlan F, Smulian J, Hiatt M, Hegyi T. Umbilical vein interleukin-6 levels in very low birth weight infants developing intraventricular hemorrhage. Brain Dev 2005 27 483-487
17. Yoon B H., Romero R, Park J S. et al. The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol 2000 183 1124-1129
18. Yoon B H., Romero R, Kim K S. et al. A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia. Am J Obstet Gynecol 1999 181 773-779
19. Heep A, Behrendt D, Nitsch P, Fimmers R, Bartmann P, Dembinski J. Increased serum levels of interleukin 6 are associated with severe intraventricular haemorrhage in extremely premature infants. Arch Dis Child Fetal Neonatal Ed 2003 88 F501-F504
20. Ghezzi F, Franchi M, Raio L et al. Elevated amniotic fluid C-reactive protein at the time of genetic amniocentesis is a marker for preterm delivery. Am J Obstet Gynecol 2002 186 268-273
21. Yoon B H., Romero R, Shim J Y., Shim S S., Kim C J., Jun J K. C-reactive protein in umbilical cord blood: a simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis. J Matern Fetal Neonatal Med 2003 14 85-90
22. Athayde N, Edwin S S., Romero R et al. A role for matrix metalloproteinase-9 in spontaneous rupture of the fetal membranes. Am J Obstet Gynecol 1998 179 1248-1253
23. Maymon E, Romero R, Pacora P et al. Evidence of in vivo differential bioavailability of the active forms of matrix metalloproteinases 9 and 2 in parturition, spontaneous rupture of membranes, and intra-amniotic infection. Am J Obstet Gynecol 2000 183 887-894
24. Romero R, Chaiworapongsa T, Espinoza J et al. Fetal plasma MMP-9 concentrations are elevated in preterm premature rupture of the membranes. Am J Obstet Gynecol 2002 187 1125-1130
25. Schulz C G., Sawicki G, Lemke R P., Roeten B M., Schulz R, Cheung P Y. MMP-2 and MMP-9 and their tissue inhibitors in the plasma of preterm and term neonates. Pediatr Res 2004 55 794-801
26. Sweet D G., Curley A E., Chesshyre E et al. The role of matrix metalloproteinases-9 and -2 in development of neonatal chronic lung disease. Acta Paediatr 2004 93 791-796
27. Wapner R J., Sorokin Y, Thom E A. et al, National Institute of Child Health and Human Development Maternal Fetal Medicine Units Network. Single versus weekly courses of antenatal corticosteroids: evaluation of safety and efficacy. Am J Obstet Gynecol 2006 195 633-642
28. Papile L A., Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978 92 529-534
29. Murtha A P., Greig P C., Jimmerson C E., Herbert W NP. Maternal serum interleukin-6 concentration as a marker for impending preterm delivery. Obstet Gynecol 1998 91 161-164
30. Pfeiffer K A., Reinsberg J, Rahmun A, Schmolling J, Krebs D. Clinical application of maternal serum cytokine determination in premature rupture of membranesinterleukin-6, an early predictor of neonatal infection? Acta Obstet Gynecol Scand 1999 78 774-778
31. Turhan N O., Karabulut A, Adam B. Maternal serum interleukin 6 levels in preterm labor: prediction of admission-to-delivery interval. J Perinat Med 2000 28 133-139
32. Lewis D F., Barrilleaux P S., Wang Y, Adair C D., Baier J, Kruger T. Detection of interleukin-6 in maternal plasma predicts neonatal and infectious complications in preterm premature rupture of membranes. Am J Perinatol 2001 18 387-391
33. Goldenberg R L., Iams J D., Mercer B M. et al, Maternal-Fetal Medicine Units Network. The Preterm Prediction Study: toward a multiple-marker test for spontaneous preterm birth. Am J Obstet Gynecol 2001 185 643-651
34. Bahar A M., Ghalib H W., Moosa R A., Zaki Z M., Thomas C, Nabri O A. Maternal serum interleukin-6, interleukin-8, tumor necrosis factor-alpha and interferon-gamma in preterm labor. Acta Obstet Gynecol Scand 2003 82 543-549
35. Sozmen S, Mungan T, Micozkadioglu S D., Tapisiz O L., Tapisiz O L. Predictive value of maternal serum and vaginal interleukin-6 levels in preterm labor. J Soc Gynecol Investig 2005 12 e1-e6
36. Pitiphat W, Gillman M W., Joshipura K J., Williams P L., Douglass C W., Rich-Edwards J W. Plasma C-reactive protein in early pregnancy and preterm delivery. Am J Epidemiol 2005 162 1108-1113
37. Skrablin S, Lovric H, Banovic V, Kralik S, Dijakovic A, Kalafatic D. Maternal plasma interleukin-6, interleukin-1beta and C-reactive protein as indicators of tocolysis failure and neonatal outcome after preterm delivery. J Matern Fetal Neonatal Med 2007 20 335-341
38. Trochez-Martinez R D., Smith P, Lamont R F. Use of C-reactive protein as a predictor of chorioamnionitis in preterm prelabour rupture of membranes: a systematic review. BJOG 2007 114 796-801
39. Vogel I, Goepfert A R., Thorsen P et al. Early second-trimester inflammatory markers and short cervical length and the risk of recurrent preterm birth. J Reprod Immunol 2007 75 133-140