C-reactive protein in umbilical cord blood: A simple and widely available clinical method to assess the risk of amniotic fluid infection and funisitis

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 14, Issue 2, 2003, Pages 85-90

  Yoon, B H ^a,c   Romero, R ^b   Shim, J Y ^a   Shim, S S ^a   Kim, C J ^a   Jun, J K ^a  

^a Seoul National University College of Medicine   (South Korea)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c Seoul National University Hospital   (South Korea)

Author keywords

Amniotic Fluid Infection; C reactive Protein; Funisitis; Interleukin 6; Prematurity; Sepsis; Umbilical Cord Blood

Indexed keywords

C REACTIVE PROTEIN; INTERLEUKIN 6;

AMNIOCENTESIS; AMNION FLUID; AMNIONITIS; ARTICLE; BACTERIUM CULTURE; CLINICAL EXAMINATION; COMPARATIVE STUDY; CONGENITAL INFECTION; FUNISITIS; HUMAN; IMMUNOASSAY; INFLAMMATORY DISEASE; MAJOR CLINICAL STUDY; NEWBORN; NEWBORN SEPSIS; PREMATURITY; PRIORITY JOURNAL; PROTEIN DETERMINATION; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; UMBILICAL CORD; UMBILICAL CORD BLOOD;

EID: 0042427566     PISSN: 14767058     EISSN: None     Source Type: Journal    
DOI: 10.1080/jmf.14.2.85.90     Document Type: Article

References (36)

1. Romero R, Sirtori M, Oyarzun E, et al. Infection and labor. V. Prevalence, microbiology, and clinical significance of intraamniotic infection in women with preterm labor and intact membranes. Am J Obstet Gynecol 1989;161:817-24
2. Romero R, Quintero R, Oyarzun E, et al. Intraamniotic infection and the onset of labor in preterm premature rupture of the membranes. Am J Obstet Gynecol 1988;159:661-6
3. Bobitt JR, Hayslip CC, Damato JD. Amniotic fluid infection as determined by transabdominal amniocentesis in patients with intact membranes in premature labor. Am J Obstet Gynecol 1981;140:947-52
4. Hameed C, Tejani N, Verma UL, et al. Silent chorioamnionitis as a cause of preterm labor refractory to tocolytic therapy. Am J Obstet Gynecol 1984;149:726-30
5. Romero R, Mazor M. Infection and preterm labor. Clin Obstet Gynecol 1988;31:553-84
6. Skoll MA, Moretti ML, Sibai BM. The incidence of positive amniotic fluid cultures in patients preterm labor with intact membranes. Am J Obstet Gynecol 1989;161:813-16
7. Watts DH, Krohn MA, Hillier SL, et al. Characteristics of women in preterm labor associated with elevated C-reactive protein levels. Obstet Gynecol 1993;82:509-14
8. Yoon BH, Chang JW, Romero R. Isolation of Ureaplasma urealyticum from the amniotic cavity and adverse outcome in preterm labor. Obstet Gynecol 1998;92:77-82
9. Garite TJ, Freeman RK. Chorioamnionitis in the preterm gestation. Obstet Gynecol 1982;59:539-45
10. Gravett MG, Hummel D, Eschenbach DA, et al. Preterm labor associated with subclinical amniotic fluid infection and with bacterial vaginosis. Obstet Gynecol 1986;67:229-37
11. Carroll SG, Ville Y, Greenough A, et al. Preterm prelabour amniorrhexis: intrauterine infection and interval between membrane rupture and delivery. Arch Dis Child Fetal Neonat Ed 1995;72:F43-6
12. Ohlsson A, Vearncombe M. Congenital and nosocomial sepsis in infants born in a regional perinatal unit: cause, outcome, and white blood cell response. Am J Obstet Gynecol 1987;156:407-13
13. Simon C, Schroder H, Beyer C, et al. Neonatal sepsis in an intensive care unit and results of treatment. Infection 1991;19:146-9
14. Insoft RM, Sola A. Perinatally acquired Pseudomonas infection: a newly recognized maternal risk factor. Am J Perinatol 1995;12:25-6
15. Sinha SK, Davies JM, Sims DG, et al. Relation between periventricular haemorrhage and ischaemic brain lesions diagnosed by ultrasound in very pre-term infants. Lancet 1985;2:1154-6
16. Han TR, Bang MS, Lim JY, et al. Risk factors of cerebral palsy in preterm infants. Am J Phys Med Rehabil 2002;81:297-303
17. Yoon BH, Romero R, Park JS, et al. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol 2000;182:675-81
18. Pacora P, Chaiworapongsa T, Maymon E, et al. Funisitis and chorionic vasculitis: the histological counterpart of the fetal inflammatory response syndrome. J Matern Fetal Neonat Med 2002;11:18-25
19. Rogers BB, Alexander JM, Head J, et al. Umbilical vein interleukin-6 levels correlate with the severity of placental inflammation and gestational age. Hum Pathol 2002;33:335-40
20. Naccasha N, Hinson R, Montag A, et al. Association between funisitis and elevated interleukin-6 in cord blood. Obstet Gynecol 2001;97:220-4
21. Yoon BH, Romero R, Park JS, et al. The relationship among inflammatory lesions of the umbilical cord (funisitis), umbilical cord plasma interleukin 6 concentration, amniotic fluid infection, and neonatal sepsis. Am J Obstet Gynecol 2000;183:1124-9
22. Kashlan F, Smulian J, Shen-Schwarz S, et al. Umbilical vein interleukin 6 and tumor necrosis factor alpha plasma concentrations in the very preterm infant. Pediatr Infect Dis J 2000;19:238-43
23. Miyano A, Miyamichi T, Nakayama M, et al. Differences among acute, subacute, and chronic chorioamnionitis based on levels of inflammation-associated proteins in cord blood. Pediatr Dev Pathol 1998;1:513-21
24. Yoon BH, Romero R, Kim CJ, et al. Amniotic fluid interleukin-6: a sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity. Am J Obstet Gynecol 1995;172:960-70
25. Galen RS, Gambino SR. Evaluation of laboratory tests: comparing sensitivity and specificity data. In Beyond Normality: the Predictive Value and Efficiency of Medical Diagnoses. New York: John Wiley, 1975:131-40
26. Ridker PM, Rifai N, Rose L, et al. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med 2002;347:1557-65
27. Gomez R, Romero R, Ghezzi F, et al. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998;179:194-202
28. Starr SE. Antimicrobial therapy of bacterial sepsis in the newborn infant. J Pediatr 1985;106:1043-8
29. Mercer BM, Carr TL, Beazley DD, et al. Antibiotic use in pregnancy and drug-resistant infant sepsis. Am J Obstet Gynecol 1999;181:816-21
30. Levine EM, Ghai V, Barton JJ, et al. Intrapartum antibiotic prophylaxis increases the incidence of gram-negative neonatal sepsis. Infect Dis Obstet Gynecol 1999;7:210-13
31. Towers CV, Carr MH, Padilla G, et al. Potential consequences of widespread antepartal use of ampicillin. Am J Obstet Gynecol 1998;179:879-83
32. Smulian JC, Bhandari V, Campbell WA, et al. Value of umbilical artery and vein levels of interleukin-6 and soluble intracellular adhesion molecule-1 as predictors of neonatal hematologic indices and suspected early sepsis. J Matern Fetal Med 1997;6:254-9
33. Smulian JC, Vintzileos AM, Lai YL, et al. Maternal chorioamnionitis and umbilical vein interleukin-6 levels for identifying early neonatal sepsis. J Matern Fetal Med 1999;8:88-94
34. Miyano A, Miyamichi T, Nakayama M, et al. Effect of chorioamnionitis on the levels of serum proteins in the cord blood of premature infants. Arch Pathol Lab Med 1996;120:245-8
35. Dollner H, Vatten L, Halgunset J, et al. Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors. Br J Obstet Gynaecol 2002;109:534-9
36. Dollner H, Vatten L, Austgulen R. Early diagnostic markers for neonatal sepsis: comparing C-reactive protein, interleukin-6, soluble tumour necrosis factor receptors and soluble adhesion molecules. J Clin Epidemiol 2001;54:1251-7