Contribution of serum inflammatory markers to changes in bone mineral content and density in postmenopausal women: A 1-year investigation

Journal of Clinical Densitometry

Volumn 13, Issue 3, 2010, Pages 277-282

  Gertz, E R ^a   Silverman, N E ^b   Wise, K S ^b   Hanson, K B ^c   Alekel, D L ^c   Stewart, J W ^c   Perry, C D ^c   Bhupathiraju, S N ^c   Kohut, M L ^c   Van Loan, M D ^a  

^a AGRICULTURAL RESEARCH SERVICE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c IOWA STATE UNIVERSITY   (United States)

Author keywords

Bone mineral content (BMC) and density (BMD); Cytokines; Inflammatory markers; Postmenopausal women

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; ISOFLAVONE; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BONE DENSITY; BONE MINERAL; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DOUBLE BLIND PROCEDURE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HIP; HUMAN; LEUKOCYTE COUNT; LUMBAR SPINE; MULTICENTER STUDY; MULTIPLE REGRESSION; OSSIFICATION; OSTEOLYSIS; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SOYBEAN;

BONE DENSITY; C-REACTIVE PROTEIN; FEMALE; FEMUR; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LEUKOCYTE COUNT; LUMBAR VERTEBRAE; MIDDLE AGED; POSTMENOPAUSE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77955514856     PISSN: 10946950     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocd.2010.04.003     Document Type: Article

References (16)

1. Alliston T., Derynck R. Interfering with bone remodeling. Nature 2002, 416:686-687.
2. Heaney R.P. Bone health. Am J Clin Nutr 2007, 85:300S-303S.
3. Teitelbaum S. Osteoclasts: what do they do and how do they do it?. Am J Pathol 2007, 170:427-435.
4. Arron J., Choi Y. Bone versus immune system. Nature 2000, 408:535-536.
5. Walsh M.C., Kim N., Kadono Y., et al. Osteoimmunology: interplay between the immune system and bone metabolism. Annu Rev Immunol 2006, 24:33-63.
6. Karouzakis E., Neidhart M., Gay R.E., et al. Molecular and cellular basis of rheumatoid joint destruction. Immunol Lett 2006, 106(1):8-13.
7. Riggs B. The mechanisms of estrogen regulation of bone resorption. J Clin Invest 2000, 106:1203-1204.
8. Pfeilschifter J., Köditz R., Pfohl M., et al. Changes in proinflammatory cytokine activity after menopause. Endocr Rev 2002, 23:90-119.
9. Alekel D.L., Van Loan M.D., Koehler K.J., et al. Soy Isoflavones for Reducing Bone Loss (SIRBL) study: three-year randomized controlled trial in postmenopausal women. Am J Clin Nutr 2010, 91:218-230.
10. Shedd K.M., Hanson K.B., Alekel D.L., et al. Quantifying leisure physical activity and its relation to bone density and strength. Med Sci Sports Exerc 2007, 39:2189-2198.
11. Tomiyama H., Okazaki R., Koji Y., et al. Elevated C-reactive protein: a common marker for atherosclerotic cardiovascular risk and subclinical stages of pulmonary dysfunction and osteopenia in a healthy population. Atherosclerosis 2005, 178:187-192.
12. Ganesan K., Teklehaimanot S., Tran T.H., et al. Relationship of C-reactive protein and bone mineral density in community-dwelling elderly females. J Natl Med Assoc 2005, 97:329-333.
13. Koh J.M., Khang Y.H., Jung C.H., et al. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int 2005, 16:1263-1271.
14. Perry C.D., Alekel D.L., Ritland L.M., et al. Centrally located body fat is related to inflammatory markers in healthy postmenopausal women. Menopause 2008, 15:619-627.
15. Pacifici R., Brown C., Puscheck E., et al. Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc Natl Acad Sci USA 1991, 88:5134-5138. [PubMed: 2052592].
16. Ushiroyama T., Ikeda A., Ueki M. Elevated plasma interleukin-6 (IL-6) and soluble IL-6 receptor concentrations in menopausal women with and without depression. Int J Gynaecol Obstet 2002, 79:51-52. [PubMed: 12399096].