Investigating the structural influence of surface mutations on acetylcholinesterase inhibition by organophosphorus compounds and oxime reactivation

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 238-240

  Küçükkilinç, Tuba ^a,b   Cochran, Rory ^a   Kalisiak, Jaroslaw ^c   Garcia, Edzna ^a   Valle, Anne ^a   Amitai, Gabi ^d   Radić, Zoran ^a   Taylor, Palmer ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b HACETTEPE UNIVERSITY   (Turkey)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

Acetylcholinesterase; Catalysis; Organophosphates; Oxime reactivation; Surface mutations

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; ALANINE; ASPARTIC ACID; CYCLOSARIN; GLUTAMIC ACID; GLUTAMINE; HISTIDINE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; MUTANT PROTEIN; ORGANOPHOSPHORUS COMPOUND; OXIME; PARAOXON; PHENYLALANINE; PRALIDOXIME; SOMAN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME PHOSPHORYLATION; ENZYME REACTIVATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; MUTATION; SINGLE NUCLEOTIDE POLYMORPHISM; WILD TYPE;

MAMMALIA;

EID: 77955510550     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.03.050     Document Type: Article

References (8)

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