The exocytosis of lytic granules is impaired in Vti1b- or Vamp8-deficient CTL leading to a reduced cytotoxic activity following antigen-specific activation

Journal of Immunology

Volumn 185, Issue 2, 2010, Pages 1005-1014

  Dressel, Ralf ^a   Elsner, Leslie ^a   Novota, Peter ^a,c   Kanwar, Namita ^b,d   Von Mollard, Gabriele Fischer ^b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b BIELEFELD UNIVERSITY   (Germany)

^c INSTITUTE OF RHEUMATOLOGY   (Czech Republic)

^d UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MESSENGER RNA; SNARE PROTEIN; SNARE PROTEIN VTI1B; SYNAPTOBREVIN; SYNAPTOBREVIN 8; UNCLASSIFIED DRUG; ANTIGEN; LAMP1 PROTEIN, MOUSE; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; QB SNARE PROTEIN; VAMP8 PROTEIN, MOUSE; VTI1B PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CELL SURFACE; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; DEGRANULATION; DENDRITIC CELL; EXOCYTOSIS; FLOW CYTOMETRY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; CD8+ T LYMPHOCYTE; CELL GRANULE; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MOUSE MUTANT; MOUSE STRAIN; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; ANTIGENS; CD8-POSITIVE T-LYMPHOCYTES; CELL DEGRANULATION; CELL LINE, TUMOR; CYTOPLASMIC GRANULES; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; EXOCYTOSIS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; LYMPHOCYTE ACTIVATION; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICE, TRANSGENIC; QB-SNARE PROTEINS; R-SNARE PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 77955507742     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000770     Document Type: Article

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