Symmetric allosteric mechanism of hexameric Escherichia coli arginine repressor exploits competition between L-arginine ligands and resident arginine residues

PLoS Computational Biology

Volumn 6, Issue 6, 2010, Pages 1-12

  Strawn, Rebecca ^a   Melichercik, Milan ^b   Green, Michael ^c,e   Stockner, Thomas ^d   Carey, Jannette ^a   Ettrich, Rüdigger ^b  

^a PRINCETON UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

^c The College of New Jersey   (United States)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; BINDING ENERGY; BINDING SITES; ESCHERICHIA COLI; FREE ENERGY; HYDROGEN BONDS; MOLECULAR DYNAMICS; POSITIVE IONS; REACTION KINETICS;

ALLOSTERIC MECHANISMS; ALLOSTERY; ARGININE RESIDUE; ASPARTATE RESIDUE; COOPERATIVITY; DYNAMICS SIMULATION; L-ARGININE; MOLECULAR MECHANISM; SIMPLE++; SYMMETRICS;

LIGANDS;

ARGININE; ARGININE REPRESSOR; ASPARTIC ACID; UNCLASSIFIED DRUG; ARGR PROTEIN, E COLI; DNA; ESCHERICHIA COLI PROTEIN; REPRESSOR PROTEIN;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENERGY TRANSFER; ENTROPY; ESCHERICHIA COLI; HYDROGEN BOND; LIGAND BINDING; MOLECULAR DYNAMICS; MOLECULAR EVOLUTION; NONHUMAN; SPECIES DISTRIBUTION; THERMODYNAMICS; BINDING SITE; CHEMISTRY; CONFORMATION; METABOLISM;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; ARGININE; DNA; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MOLECULAR CONFORMATION; MOLECULAR DYNAMICS SIMULATION; REPRESSOR PROTEINS; THERMODYNAMICS;

EID: 77955497249     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000801     Document Type: Article

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