Acétylation de la chromatine, régulation des gènes et dépression

Medecine/Sciences

Volumn 26, Issue 5, 2010, Pages 465-467

  Vialou, Vincent ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BENZAMIDE DERIVATIVE; FLUOXETINE; HISTONE; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; N (2 AMINOPHENYL) 4 (N (PYRIDIN 3 YLMETHOXYCARBONYL)AMINOMETHYL)BENZAMIDE; N-(2-AMINOPHENYL)-4-(N-(PYRIDIN-3-YLMETHOXYCARBONYL)AMINOMETHYL)BENZAMIDE; NERVE PROTEIN; PYRIDINE DERIVATIVE;

ACETYLATION; ANIMAL; BIOSYNTHESIS; DEPRESSION; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; HUMAN; INJECTION; MENTAL STRESS; METABOLISM; MOUSE; NOTE; NUCLEUS ACCUMBENS; PHYSIOLOGY; PROTEIN PROCESSING;

ACETYLATION; ANIMALS; ANTIDEPRESSIVE AGENTS; BENZAMIDES; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; FLUOXETINE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HISTONES; HUMANS; INJECTIONS; MICE; NERVE TISSUE PROTEINS; NUCLEUS ACCUMBENS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIDINES; STRESS, PSYCHOLOGICAL;

EID: 77955495969     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/2010265465     Document Type: Article

References (11)

1. Rush AJ, Trivedi MH, Wisniewski SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry 2006; 163: 1905-17.
2. Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci 2007; 8: 355-67.
3. Ray-Gallet D, Gérard A, Polo S, Almouzni G. Variations sur le thème du code histone. Med Sci (Paris) 2005; 21: 384-9.
4. rd, Maze I, LaPlant QC, et al. Antidepressant actions of histone deacetylase inhibitors. J Neurosci 2009; 22: 11451-60.
5. Nestler EJ, Carlezon WA Jr. The mesolimbic dopamine reward circuit in depression. Biol Psychiatry 2006; 59: 1151-9.
6. Berton O, McClung CA, Dileone RJ, et al. Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science 2006; 311: 864-8.
7. rd, Vialou V, Nestler EJ. From synapse to nucleus: Novel targets for treating depression. Neuropharmacology 2010; 58: 683-93.
8. Buchwald M, Kramer OH, Heinzel T. HDACi: targets beyond chromatin. Cancer Lett 2009; 280: 160-7.
9. Renthal W, Kumar A, Xiao G, et al. Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron 2009; 62: 335-48.
10. Grayson DR, Kundakovic M, Sharma RP. Is there a future for histone deacetylase inhibitors in the pharmacotherapy of psychiatric disorders? Mol Pharmacol 2010; 77: 126-35.
11. Simonini MV, Camargo LM, Dong E, et al. The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases. Proc Natl Acad Sci USA 2006; 103: 1587-92.