Length of intravenous antibiotic therapy and treatment failure in infants with urinary tract infections

Pediatrics

Volumn 126, Issue 2, 2010, Pages 196-203

  Brady, Patrick W ^a   Conway, Patrick H ^a   Goudie, Anthony ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Children; Hospital medicine; Infants; Therapy; Urinary tract infection

Indexed keywords

ANTIBIOTIC AGENT;

ANTIBIOTIC THERAPY; ARTICLE; CLINICAL EVALUATION; COHORT ANALYSIS; FEMALE; GROUPS BY AGE; HOSPITAL READMISSION; HOSPITALIZATION; HUMAN; INFANT; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATION SYSTEM; NEWBORN; OUTCOME ASSESSMENT; PREDICTOR VARIABLE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCORING SYSTEM; TREATMENT DURATION; TREATMENT FAILURE; URINARY TRACT INFECTION; UROGENITAL TRACT MALFORMATION;

ANTI-BACTERIAL AGENTS; COHORT STUDIES; FEMALE; HOSPITALIZATION; HUMANS; INFANT; INFANT, NEWBORN; INJECTIONS, INTRAVENOUS; LENGTH OF STAY; MALE; PREVALENCE; RETROSPECTIVE STUDIES; TIME FACTORS; TREATMENT FAILURE; URINARY TRACT INFECTIONS;

EID: 77955494520     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2009-2948     Document Type: Article

References (31)

1. Bachur RG, Harper MB. Predictive model for serious bacterial infections among infants younger than 3 months of age. Pediatrics. 2001;108(2):311-316 (Pubitemid 33607854)
2. Baker MD, Bell LM, Avner JR. Outpatient management without antibiotics of fever in selected infants. N Engl J Med. 1993;329(20):1437-1441
3. Bonadio WA, McElroy K, Jacoby PL, Smith D. Relationship of fever magnitude to rate of serious bacterial infections in infants aged 4-8 weeks. Clin Pediatr (Phila). 1991;30(8):478-480
4. Kadish HA, Loveridge B, Tobey J, Bolte RG, Corneli HM. Applying outpatient protocols in febrile infants 1-28 days of age: can the threshold be lowered? Clin Pediatr (Phila). 2000;39(2):81-88
5. Hoberman A, Charron M, Hickey RW, Baskin M, Kearney DH, Wald ER. Imaging studies after a first febrile urinary tract infection in young children. N Engl J Med. 2003;348(3):195-202 (Pubitemid 36077914)
6. Greenfield SP, Ng M, Wan J. Experience with vesicoureteral reflux in children: clinical characteristics. J Urol. 1997;158(2):574-577
7. Lin KY, Chiu NT, Chen MJ, et al. Acute pyelonephritis and sequelae of renal scar in pediatric first febrile urinary tract infection. Pediatr Nephrol. 2003;18(4):362-365
8. Wennerström M, Hansson S, Jodal U, Stokland E. Primary and acquired renal scarring in boys and girls with urinary tract infection. J Pediatr. 2000;136(1):30-34 (Pubitemid 30468553)
9. Smellie JM, Ransley PG, Normand IC, Prescod N, Edwards D. Development of new renal scars: a collaborative study. Br Med J (Clin Res Ed). 1985;290(6486):1957-1960
10. Winberg J, Bergström T, Jacobsson B. Morbidity, age and sex distribution, recurrences and renal scarring in symptomatic urinary tract infection in childhood. Kidney Int Suppl. 1975;4:S101-S106
11. American Academy of Pediatrics, Committee on Quality Improvement, Subcommittee on Urinary Tract Infection. Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. Pediatrics. 1999;103(4):843-852
12. Keren R, Chan E. A meta-analysis of randomized, controlled trials comparing short- and long-course antibiotic therapy for urinary tract infections in children. Pediatrics. 2002; 109(5). Available at: www.pediatrics.org/cgi/ content/full/109/5/e70
13. Mori R, Lakhanpaul M, Verrier-Jones K. Diagnosis and management of urinary tract infection in children: summary of NICE guidance. BMJ. 2007;335(7616):395-397 (Pubitemid 47359319)
14. Hoberman A, Wald ER, Hickey RW, et al. Oral versus initial intravenous therapy for urinary tract infections in young febrile children. Pediatrics. 1999;104(1):79-86
15. Montini G, Toffolo A, Zucchetta P, et al. Antibiotic treatment for pyelonephritis in children: multicentre randomised controlled non-inferiority trial. BMJ. 2007;335(7616):386
16. Conway PH, Keren R. Factors associated with variability in outcomes for children hospitalized with urinary tract infection. J Pediatr. 2009;154(6):789-796
17. Zaoutis T, Localio AR, Leckerman K, Saddlemire S, Bertoch D, Keren R. Prolonged intravenous therapy versus early transition to oral antimicrobial therapy for acute osteomyelitis in children. Pediatrics. 2009;123(2):636-642
18. Conway PH, Cnaan A, Zaoutis T, Henry BV, Grundmeier RW, Keren R. Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials. JAMA. 2007;298(2):179-186 (Pubitemid 47057764)
19. D'Agostino RB Jr. Propensity score methods for bias reduction in the comparison of a treatment to a non-randomized control group. Stat Med. 1998;17(19):2265-2281
20. Rubin DB. Estimating causal effects from large data sets using propensity scores. Ann Intern Med. 1997;127(8):757-763
21. King G, Zeng L. Logistic regression in rare events data. Polit Anal. 2001;9(2):137-163
22. Whitley E, Ball J. Statistics review 4: sample size calculations. Crit Care. 2002;6(4):335-341 (Pubitemid 34863702)
23. Conway PH, Edwards S, Stucky ER, Chiang VW, Ottolini MC, Landrigan CP. Variations in management of common inpatient pediatric illnesses: hospitalists and community pediatricians. Pediatrics. 2006;118(2):441-447
24. Linshaw MA. Controversies in childhood urinary tract infections. World J Urol. 1999;17(6):383-395
25. Garin EH, Olavarria F, Garcia Nieto V, Valenciano B, Campos A, Young L. Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study. Pediatrics. 2006;117(3):626-632
26. Darmstadt GL, Batra M, Zaidi AK. Oral antibiotics in the management of serious neonatal bacterial infections in developing country communities. Pediatr Infect Dis J. 2009;28(1 suppl):S31-S36
27. Cohen MD, Raeburn JA, Devine J, et al. Pharmacology of some oral penicillins in the newborn infant. Arch Dis Child. 1975;50(3):230-234
28. Heimann G. Enteral absorption and bioavailability in children in relation to age. Eur J Clin Pharmacol. 1980;18(1):43-50 (Pubitemid 10090665)
29. Gras-Le Guen C, Boscher C, Godon N, et al. Therapeutic amoxicillin levels achieved with oral administration in term neonates. Eur J Clin Pharmacol. 2007;63(7):657-662
30. Benador D, Neuhaus TJ, Papazyan JP, et al. Randomised controlled trial of three day versus 10 day intravenous antibiotics in acute pyelonephritis: effect on renal scarring. Arch Dis Child. 2001;84(3):241-246
31. Mahant S, Friedman J, MacArthur C. Renal ultrasound findings and vesicoureteral reflux in children hospitalised with urinary tract infection. Arch Dis Child. 2002;86(6):419-420 (Pubitemid 34596652)