AEB-071 versus tacrolimus monotherapy to prevent acute cardiac allograft rejection in the rat: A preliminary report

Transplantation Proceedings

Volumn 42, Issue 3, 2010, Pages 976-979

  Fang, Y H ^a   Joo, D J ^a   Lim, B J ^a   Kim, J Y ^a   Kim, M S ^a   Jeong, H J ^a   Kim, Y S ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

PYRROLE DERIVATIVE; QUINAZOLINE DERIVATIVE; SOTRASTAURIN; TACROLIMUS;

ALLOTRANSPLANTATION; ANIMAL; ARTICLE; BROWN NORWAY RAT; DRUG EFFECT; GRAFT REJECTION; GRAFT SURVIVAL; HEART CONTRACTION; HEART TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; IMMUNOLOGY; LEWIS RAT; LYMPHOCYTE ACTIVATION; MALE; PHYSIOLOGY; RAT; T LYMPHOCYTE;

ANIMALS; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MALE; MYOCARDIAL CONTRACTION; PYRROLES; QUINAZOLINES; RATS; RATS, INBRED BN; RATS, INBRED LEW; T-LYMPHOCYTES; TACROLIMUS; TRANSPLANTATION, HETEROTOPIC; TRANSPLANTATION, HOMOLOGOUS;

EID: 77955478891     PISSN: 00411345     EISSN: 18732623     Source Type: Journal    
DOI: 10.1016/j.transproceed.2010.02.034     Document Type: Conference Paper

References (21)

1. M. Spitaler, and D.A. Cantrell Protein kinase C and beyond Nat Immunol 5 2004 785
2. G. Baier The PKC gene module: molecular biosystematics to resolve its T cell functions Immunol Rev 192 2003 64
3. S. Tan, and P.J. Parker Emerging and diverse roles of protein kinase C in immune cell signalling Biochem J 376 2003 545
4. J.-P. Evenou, N. Thuille, and S. Cottens NVP-AEB071(AEB), a novel protein kinase C inhibitor, abrogates early mouse T cell activation without affecting activation induced cell death Am J Transplant 6 suppl 2 2006 1029
5. J.-P. Evenou, V. Brinkmann, and H. Towbin Enzymatic cellular characterization of NVP-AEB071 (AEB), a novel selective protein kinase C (PKC) inhibitor that blocks early T cell activation, and its use to define the role of PKC in T cells Am J Transplant 6 suppl 2 2006 1026
6. K. Ono, and E.S. Lindsey Improved technique of heart transplantation in rats J Thorac Cardiovasc Surg 57 1969 225
7. H. Chen, H. Luo, and P. Daloze Long-term in vivo effects of rapamycin on humoral and cellular immune responses in the rat Immunobiology 188 1993 303
8. H. Chen, J. Wu, and D. Xu Reversal of ongoing heart, kidney, and pancreas allograft rejection and suppression of accelerated heart allograft rejection in the rat by rapamycin Transplantation 56 1993 661
9. M.D. Vu, S. Qi, and D. Xu Synergistic effects of mycophenolate mofetil and sirolimus in prevention of acute heart, pancreas, and kidney allograft rejection and in reversal of ongoing heart allograft rejection in the rat Transplantation 66 1998 1575
10. S. Stewart, G.L. Winters, and M.C. Fishbein Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection J Heart Lung Transplant 24 2005 1710
11. P.F. Halloran Immunosuppressive drugs for kidney transplantation N Engl J Med 351 2004 2715
12. M.H. Sayegh, and C.B. Carpenter Transplantation 50 years later - progress, challenges, and promises N Engl J Med 351 2004 2761
13. H.U. Meier-Kriesche, S. Li, and R.W. Gruessner Immunosuppression: evolution in practice and trends, 1994-2004 Am J Transplant 6 2006 1111
14. C. Magee, and M. Pascual Update in renal transplantation Arch Intern Med 164 2004 1373
15. R. Shapiro, M. Jordan, and V.P. Scantlebury Renal transplantation at the University of Pittsburgh: the impact of FK506 Clin Transpl 1994 229
16. A.C. Newton Regulation of protein kinase C Curr Opin Cell Biol 9 1997 161
17. Y. Takai, A. Kishimoto, and M. Inoue Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues I. Purification and characterization of an active enzyme from bovine cerebellum J Biol Chem 252 1977 7603
18. C.R. Monks, H. Kupfer, and I. Tamir Selective modulation of protein kinase C-theta during T-cell activation Nature 385 1997 83
19. B.J. Marsland, and M. Kopf T-cell fate and function: PKC-theta and beyond Trends Immunol 29 2008 179
20. S. Merani, R.L. Pawlick, and R.L. Edgar Protein kinase C inhibitor, AEB-071, acts complementarily with cyclosporine to prevent islet rejection in rats Transplantation 87 2009 59
21. M.E. Billingham, N.R. Cary, and M.E. Hammond A working formulation for the standardization of nomenclature in the diagnosis of heart and lung rejection: Heart Rejection Study Group The International Society for Heart Transplantation J Heart Transplant 9 1990 587